National Consortium on Alcohol and Neurodevelopment in Adolescence: San Diego

国家酒精与青春期神经发育联盟：圣地亚哥

基本信息

批准号：
9384846
负责人：
SUSAN F TAPERT
金额：
$ 82.22万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9384846
关键词：
Abstinence Acute Address Adolescence Adolescent Adolescent Development Adolescent and Young Adult Adult Adverse effects Affective Age Alcohol consumption Alcohol or Other Drugs use Alcohols Anisotropy Area Behavior Behavior assessment Behavioral Biological Brain Childhood Chronic Clinical assessments Cognitive Collection Corpus striatum structure Cox Proportional Hazards Models Data Development Diffusion Magnetic Resonance Imaging Dose Education Employment Environment Equipment and supply inventories Event Foundations Functional Magnetic Resonance Imaging Health Heart Rate Heavy Drinking Human Individual Legal Life Magnetic Resonance Imaging Mediating Mental Health Mental disorders Modeling Monitor Neuraxis Neurobiology Neurocognitive Neuropsychology Outcome Parietal Participant Pattern Phase Post-Traumatic Stress Disorders Prefrontal Cortex Prevention program Psychosocial Factor Public Policy Recording of previous events Recovery Regulation Reporting Research Project Grants Rest Rewards Risk Sampling Sex Characteristics Sex Differentiation Site Statistical Models Stress Structure Substance Use Disorder Symptoms System Teenagers Variant Visit Work Youth acronyms age effect alcohol consequences alcohol effect alcohol expectancy alcohol exposure alcohol measurement alcohol risk alcohol use disorder binge drinking cognitive control cognitive development cognitive testing cohort depressive symptoms drinking drinking onset emerging adult executive function experience externalizing behavior genetics of alcoholism gray matter information processing longitudinal design mobile application multimodality neural circuit neurodevelopment neuroimaging neurotoxic psychobiologic psychologic relating to nervous system resilience response sex twelfth grade underage drinking white matter young adult

项目摘要

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use2. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the UCSD site of NCANDA-2 will continue to follow a cohort of 211 San Diego-area (n=831 across all 5 sites) participants (ages 12-21 at baseline visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and multimodal assessments in the natural environment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence and young adulthood, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the UCSD site will collaborate with the Duke and OHSU sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. UCSD will also collaborate with the SRI site to collect the Stroop task in the fMRI environment to evaluate changes in the cognitive control system for youth who increase drinking versus those who do not. Sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities and resiliencies that may alter adolescents’ and young adults’ risk for alcohol or other substance use disorder and other mental health and developmental outcomes.

项目概要在成年早期，饮酒量急剧增加，酗酒水平在 22 岁时达到顶峰，几乎一半的人报告长期酗酒2。跨越20多岁的神经成熟期可能比类似的酒精对大脑和认知产生更大的影响为响应 RFA-AA-17-003，本申请提出了一个研究项目站点。国家青少年酒精与神经发育联盟第二阶段 (NCANDA-2) 确定青春期和成年早期青少年大量饮酒的预测因素和影响。为了实现这一目标，NCANDA-2 的 UCSD 站点将继续跟踪 211 个圣地亚哥地区的队列（n=831）所有 5 个站点）参与者（基线访问时年龄为 12-21 岁）获取必要的数据以加深我们的理解 NCANDA-2 会影响青少年的发育以及青少年时期饮酒对成人大脑的影响。使用多模式神经影像、认知测试、行为评估、生物样本采集和多模式对自然环境中酒精后果的评估将侧重于结构和影响。涉及青春期和成年早期积极发育的大脑区域的功能成熟在心理调节方面，对奖励做出反应，并且似乎容易受到酒精的神经毒性作用。此外，加州大学圣地亚哥分校站点将与杜克大学和 OHSU 站点合作研究这些异常的恢复。具体来说，我们将检查针对酗酒相关的神经认知和大脑的程度 UCSD 还将与 SRI 网站合作，以缓解 4 周以上的诚信缺陷。收集fMRI环境中的Stroop任务来评估青少年认知控制系统的变化增加饮酒的人与不增加饮酒的人在发育、饮酒模式和饮酒方面存在性别差异。病史、饮酒对大脑的影响以及性别差异心理社会因素（例如抑郁症）症状）将在分析中予以考虑。确定酒精暴露对青少年人脑发育轨迹的影响，以及识别可能改变青少年和年轻人的先前存在的心理生物学脆弱性和弹性酒精或其他物质使用障碍以及其他心理健康和发育结果的风险。