National Consortium on Alcohol and Neurodevelopment in Adolescence: San Diego

国家酒精与青春期神经发育联盟：圣地亚哥

• 批准号: 9384846
• 负责人: SUSAN F TAPERT
• 金额: $ 82.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9384846
• 关键词: Abstinence; Acute; Address; Adolescence; Adolescent; Adolescent Development; Adolescent and Young Adult; Adult; Adverse effects; Affective; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Anisotropy; Area; Behavior; Behavior assessment; Behavioral; Biological; Brain; Childhood; Chronic; Clinical assessments; Cognitive; Collection; Corpus striatum structure; Cox Proportional Hazards Models; Data; Development; Diffusion Magnetic Resonance Imaging; Dose; Education; Employment; Environment; Equipment and supply inventories; Event; Foundations; Functional Magnetic Resonance Imaging; Health; Heart Rate; Heavy Drinking; Human; Individual; Legal; Life; Magnetic Resonance Imaging; Mediating; Mental Health; Mental disorders; Modeling; Monitor; Neuraxis; Neurobiology; Neurocognitive; Neuropsychology; Outcome; Parietal; Participant; Pattern; Phase; Post-Traumatic Stress Disorders; Prefrontal Cortex; Prevention program; Psychosocial Factor; Public Policy; Recording of previous events; Recovery; Regulation; Reporting; Research Project Grants; Rest; Rewards; Risk; Sampling; Sex Characteristics; Sex Differentiation; Site; Statistical Models; Stress; Structure; Substance Use Disorder; Symptoms; System; Teenagers; Variant; Visit; Work; Youth; acronyms; age effect; alcohol consequences; alcohol effect; alcohol expectancy; alcohol exposure; alcohol measurement; alcohol risk; alcohol use disorder; binge drinking; cognitive control; cognitive development; cognitive testing; cohort; depressive symptoms; drinking; drinking onset; emerging adult; executive function; experience; externalizing behavior; genetics of alcoholism; gray matter; information processing; longitudinal design; mobile application; multimodality; neural circuit; neurodevelopment; neuroimaging; neurotoxic; psychobiologic; psychologic; relating to nervous system; resilience; response; sex; twelfth grade; underage drinking; white matter; young adult

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use2. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the UCSD site of NCANDA-2 will continue to follow a cohort of 211 San Diego-area (n=831 across all 5 sites) participants (ages 12-21 at baseline visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and multimodal assessments in the natural environment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence and young adulthood, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the UCSD site will collaborate with the Duke and OHSU sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. UCSD will also collaborate with the SRI site to collect the Stroop task in the fMRI environment to evaluate changes in the cognitive control system for youth who increase drinking versus those who do not. Sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities and resiliencies that may alter adolescents’ and young adults’ risk for alcohol or other substance use disorder and other mental health and developmental outcomes.

项目摘要 在成年期间，饮酒急剧增加，暴饮暴食水平在22岁时达到顶峰，几乎 一半的人报告暴饮暴食水平的酒精使用2。长时间频繁的狂饮 与类似酒精相比 在成年后期使用。为了响应RFA-AA-17-003，该应用程序提出了一个研究项目网站 青少年第二阶段（NCANDA-2）的酒精和神经发育联盟 确定青少年饮酒在青少年和成年期间的预测因素和影响。到 实现这一目标，NCANDA-2的UCSD网站将继续跟随211个圣地亚哥地区的队列（n = 831 所有5个站点）参与者（基线访问时12-21岁）以获取必要的数据以促进我们的理解 青少年发育以及青少年次数对成人大脑的影响。 Ncanda-2 Will 使用多模式的神经影像学，认知测试，行为评估，生物测定收集和多模式 自然环境中的评估。对酒精后果的检查将集中于结构和 在青少年和成年期间积极发展的大脑区域的功能成熟，涉及 在心理调节中，对奖励做出反应，并且看起来容易受到酒精的神经毒性作用。 此外，UCSD网站将与杜克和OHSU网站合作研究这些异常的恢复。 具体而言，我们将研究针对性与饮酒相关的神经认知和大脑的程度 完整性定义了在4周监测的禁欲中定义汇率。 UCSD还将与SRI网站合作 在fMRI环境中收集Stroop任务，以评估青年认知控制系统的变化 与那些没有饮酒的人相对于那些没有饮酒的人。性别差异，饮酒方式和 历史，饮酒对大脑的影响以及分化的社会心理因素（例如抑郁症 症状）将在分析中考虑。借助此续约提供的其他纵向数据，我们将 确定酒精暴露对青春期人脑发育轨迹的影响，以及 确定可能改变青少年和年轻人的精神生物学脆弱性和韧性 饮酒或其他药物使用障碍以及其他心理健康和发育结果的风险。