Translational Coordination and Dissemination Center for the SCGE Consortium

SCGE 联盟翻译协调和传播中心

• 批准号: 10666211
• 负责人: MELINDA R DWINELL
• 金额: $ 130.26万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666211
• 关键词: Academia; Acceleration; Biological Assay; Clinic; Clinical Trials; Collaborations; Communication; Communities; Complex; Data; Data Element; Development; Education and Outreach; Educational Activities; Educational workshop; Elements; Foundations; Funding; Goals; Government; Individual; Industry; Infrastructure; Leadership; Organ; Outcome; Participant; Patients; Phase; Policies; Procedures; Process; Protocols documentation; Research Design; Research Personnel; Research Project Grants; Resources; Schedule; Series; System; Technology; Testing; Tissues; Translating; Translational Research; Translations; United States National Institutes of Health; Validation; Visualization; Wisconsin; Work; data access; data format; data management; data quality; disease-causing mutation; distributed data; ethical, legal, and social implication; experience; genome editing; medical schools; meetings; member; outreach; pre-clinical; preclinical study; programs; scientific organization; somatic cell gene editing; success; tool; translational goal; user-friendly; virtual; working group

PROJECT SUMMARY The goal of the NIH Common Fund’s Somatic Cell Genome Editing (SCGE) program is to take advances in technologies aimed at genome editing and delivery system approaches to correct disease-causing mutations developed in Phase I and translate these efforts into the clinic during Phase II. The SCGE Translational Coordination and Dissemination Center (TCDC) at the Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE Dissemination and Coordinating Center acting as the hub to support the three lab and clinical trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best practices, SCGE results, and develop a network of collaboration. The SCGE TCDC at MCW brings a team of experienced investigators, platforms for effective communication and tracking of deliverables and milestones and demonstrated success in strategic collaborations within the consortium. The overall goal for the SCGE TCDC is to support the SCGE Consortium and work cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire SCGE Consortium. To accomplish this, the MCW TCDC will 1) build upon and extend the current communication platforms to facilitate communication among participants, 2) develop the infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated within the SCGE Consortium, and 3) create a robust platform for collaboration within the SCGE Consortium and with outside partners. The MCW TCDC will create the infrastructure to develop policies, track progress within the consortium, communicate within and beyond the consortium, develop outreach and educational activities to support the process of moving pre-clinical studies through the regulatory process, into clinical trials, and eventually to the patient. To disseminate data and resources developed within the SCGE Consortium, the SCGE Platform will be assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives. The MCW TCDC team will facilitate the administrative and management activities to support the overall success of the program.

项目摘要 NIH普通基金的体细胞基因组编辑（SCGE）计划的目标是采用 旨在纠正基因组编辑和输送系统方法的技术进步 在第一阶段开发了引起疾病的突变，并将这些努力转化为诊所 第二阶段。 SCGE翻译协调和传播中心（TCDC） 威斯康星州医学院（MCW）将继续努力 传播和协调中心充当支持三个实验室和临床的枢纽 基于审判的举措，以协调努力，以促进协议的传播，最佳 实践，SCGE结果并建立了协作网络。 MCW的SCGE TCDC 带来了一个经验丰富的调查员团队，有效沟通和跟踪的平台 可交付成果和里程碑，并在战略合作中取得了成功 财团。 SCGE TCDC的总体目标是支持SCGE财团和工作 与所有计划，项目和成员合作，以促进整个目标的目标 SCGE财团。为此，MCW TCDC将1）建立并扩展 当前的沟通平台以促进参与者之间的沟通，2）开发 收集，消化，注释，集成和分布的基础架构生成的数据和资源 在SCGE财团内，3）创建一个在SCGE内协作的强大平台 财团和外部合作伙伴。 MCW TCDC将创建开发基础架构 政策，跟踪财团内的进步，在财团内外交流， 开发外展​​和教育活动，以支持临床前研究的过程 通过调节过程，进入临床试验，最终进入患者。传播 SCGE联盟中开发的数据和资源，SCGE平台将是 组装以存储，查询，可视化和分析SCGE计划的结果。这 MCW TCDC团队将促进行政和管理活动，以支持 该计划的总体成功。