Dissemination and Coordinating Center for the SCGE Consortium

SCGE 联盟传播和协调中心

• 批准号: 10531271
• 负责人: MELINDA R DWINELL
• 金额: $ 114.49万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10531271
• 关键词: Acceleration; Administrative Coordination; Clinic; Collaborations; Communication; Communities; Computer software; Data; Data Element; Disease; Early Diagnosis; Education and Outreach; Educational Materials; Elements; Ensure; Equipment and supply inventories; Focus Groups; Funding; Funding Opportunities; Future Generations; Genes; Genetic Diseases; Goals; Health; Individual; Infrastructure; Knowledge; Leadership; Modeling; Patients; Policies; Procedures; Process; Protocols documentation; Research Personnel; Research Project Grants; Resources; Science; Structure; Technology; Testing; Translations; United States National Institutes of Health; Validation; Work; data format; data management; data quality; data standards; database structure; design; distributed data; ethical, legal, and social implication; genome editing; improved; innovative technologies; meetings; member; minimal risk; new technology; novel strategies; novel therapeutic intervention; programs; public repository; rare genetic disorder; repository; somatic cell gene editing; therapeutic genome editing; timeline; tool; working group

The goal of the NIH Common Fund's Somatic Cell Genome Editing (SCGE) program is to advance technologies and models that will lead to the translation of genome editing into the clinic to create new therapeutic strategies for treating both patients with rare genetic diseases, and those with common diseases. The SCGE Dissemination and Coordinating Center (DCC) will serve as the hub to promote these novel strategies and technologies to design, test, and implement approaches to treat these diseases. The SCGE DCC will support the SCGE Consortium members and work cooperatively with all groups to facilitate their scientific endeavors. To accomplish this goal, the DCC will 1) develop modes of communication for project interaction, 2) build pipelines and processes to collect, integrate, and distribute data through the SCGE Toolkit, and 3) accelerate interactions and collaborations among the groups focused on developing and testing new approaches. The DCC will create the infrastructure for information transfer among SCGE projects, to promote partnerships focused on developing, testing, and validating novel strategies to resolve genetic disorders, and to rapidly disseminate the knowledge from the SCGE to the broader scientific community. To achieve this goal, the DCC will develop a communication structure among the NIH SCGE Working Group and the project leaders, coordinate regular meetings for consortium and subcommittees, build a project management infrastructure, establish a Toolkit to disseminate results, track SCGE Consortium inventory, manage the Collaboration Opportunity Fund to support the SCGE intra-consortium partnerships, and develop educational materials. The DCC team will facilitate the administrative activities to ensure that the scientific discoveries and overall program are successful.

NIH普通基金的体细胞基因组编辑（SCGE）计划的目标是 将导致基因组编辑转化为的高级技术和模型 诊所创建新的治疗策略来治疗两名患有罕见遗传疾病的患者， 以及患有常见疾病的人。 SCGE传播和协调中心（DCC） 将作为促进这些新颖策略和技术的枢纽，以设计，测试和 实施治疗这些疾病的方法。 SCGE DCC将支持SCGE 财团成员并与所有小组合作，以促进其科学 努力。为了实现这一目标，DCC将1）开发沟通方式 项目互动，2）构建管道和流程以收集，集成和分发数据 通过SCGE工具包，以及3）加速组之间的互动和协作 专注于开发和测试新方法。 DCC将为 SCGE项目之间的信息传输，以促进专注于开发， 测试并验证解决遗传疾病并快速传播的新型策略 从SCGE到更广泛的科学界的知识。为了实现这一目标， DCC将在NIH SCGE工作组和 项目负责人，协调财团的定期会议和小组委员会，建立一个项目 管理基础架构，建立一个工具包来传播结果，跟踪SCGE财团 库存，管理协作机会基金，以支持SCGE内部委员会 合作伙伴关系，并开发教育材料。 DCC团队将促进行政 确保科学发现和整体计划成功的活动。