Cannabinoid Modulation of Cell Function

大麻素对细胞功能的调节

基本信息

批准号：
8849409
负责人：
Kenneth Mackie
金额：
$ 13.93万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-05 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8849409
关键词：
Address Adolescent Adolescent Development Agonist Alanine Analgesics Attenuated Award Behavior Behavioral Biology Brain CNR1 gene CNR2 gene Calcium Channel Inhibition Cannabinoids Cannabis Cell physiology Cells Cocaine Collaborations Complex Dependence Development Drug abuse Electrophysiology (science)Embryo Embryonic Nervous System Endocannabinoids Enzymes Eye Faculty G protein coupled receptor kinase Goals Grant Review Health Hippocampus (Brain)Indiana Knockout Mice Knowledge Lead Life Lipids MAPK8 gene Mediating Medical Students Mentors Mentorship Mus Mutate Mutation Neurons Phosphorylation Physiological Processes Postdoctoral Fellow Pre-Clinical Model Prefrontal Cortex Preparation Process Proteins Proteomics Regulation Relative (related person)Research Research Personnel Residual state Rewards Risk Role Schizophrenia Scientist Senior Scientist Serine Services Signal Pathway Signal Transduction Signaling Molecule Slice Staging Students Synaptic plasticity System Testing Therapeutic Time Training Universities Work base behavioral tolerance beta-arrestin cannabinoid receptor career career development desensitization drug of abuse editorial endogenous cannabinoid system graduate student imaging informatics inflammatory neuropathic pain innovation insight marijuana use meetings mutant patch clamp prenatal prevent programs receptor receptor internalization research study social tool university student

项目摘要

DESCRIPTION (provided by applicant): This is an application for the renewal of a senior scientist research and mentorship award to provide protected time for Ken Mackie so he can achieve the following goals for his research, mentoring, and career development. Specific research objectives during the next five years include: (1) Obtaining a comprehensive understanding of the mechanisms of CB1 cannabinoid receptor desensitization, (2) Discerning the roles of endogenous and exogenous cannabinoids during two key neurodevelopmental stages (A) during embryonic life and (B) during the adolescent maturation of the prefrontal cortex, (3) Exploring the therapeutic potential of CB2 cannabinoid receptor functional selectivity in making more effective analgesics and in attenuating cocaine reward, (4) Using simplified experimental systems (primarily cultured autaptic neurons) to address significant, outstanding issues in endocannabinoid-mediated synaptic plasticity. Dr. Mackie's mentoring will focus on mentoring four groups of scientists that encompass the full career spectrum: undergraduates at Indiana University, graduate and medical students at Indiana University, post-doctoral fellows, and junior faculty. His career development will emphasize the incorporation of more powerful imaging, informatic, proteomic, and behavioral tools into his research, as well as continuing to be heavily committed to service (editorial duties, meeting organization, and grant reviews) related to drug abuse research.

描述（由申请人提供）：这是一份续签高级科学家研究和指导奖的申请，旨在为 Ken Mackie 提供受保护的时间，以便他能够实现以下研究、指导和职业发展目标。未来五年的具体研究目标包括：（1）全面了解CB1大麻素受体脱敏机制，（2）辨别内源性和外源性大麻素在胚胎生命期间两个关键神经发育阶段（A）和（ B) 在青少年前额皮质成熟期间，(3) 探索 CB2 大麻素受体功能选择性在制造更有效镇痛药方面的治疗潜力(4) 使用简化的实验系统（主要培养自触神经元）来解决内源性大麻素介导的突触可塑性中的重大、突出问题。麦基博士的指导将侧重于指导涵盖整个职业范围的四组科学家：印第安纳大学的本科生、印第安纳大学的研究生和医学生、博士后研究员和初级教师。他的职业发展将强调将更强大的成像、信息学、蛋白质组学和行为工具纳入他的研究中，并继续大力致力于与药物滥用研究相关的服务（编辑职责、会议组织和资助审查）。