Cannabinoid

大麻素

基本信息

批准号：
7437242
负责人：
Kenneth Mackie
金额：
--
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2012-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Cannabinoid function in the CNS is a Gordon Conference whose aim is to bring together established scientists, post-docs, and graduate students interested in the neurobiology of endogenous and exogenous cannabinoids. It will be held every other year, alternating between US and European sites. The next meeting, in 2007 will be held in early fall in Les Diablerets, Switzerland. Ongoing work from a number of labs suggests that endogenous cannabinoids (endocannabinoids) play a major role in regulating short and long-term plasticity, neurodevelopment, and neuroprotection. Simultaneously, it is becoming clear that endocannabinoids are involved in several forms of behavior, including specific forms of reward for commonly abused drugs. Finally, the implications of the widespread recreational and therapeutic use of cannabinoids on the efficacy of endocannabinoid signaling are just beginning to be appreciated. It is the goal of this conference to periodically explore and integrate these relationships in depth and to identify the most important and rewarding areas to be investigated in the cannabinoid field for the next several years. Examples of topics to be investigated include: Pharmacological probes of the endocannabinoid system; Endocannabinoid synthesis and inactivation; Cannabinoid receptors and signal transduction; Cannabinoid interaction with other signaling systems; Cannabinoids and short & long term plasticity; Cannabinoids and reward: food, sex, & aversion; Endocannabinoid involvement in neuronal development; and Adaptive changes following chronic cannabinoid use.

描述（由申请人提供）：大麻素在中枢神经系统中的功能是戈登会议，其目的是将对内源性和外源性大麻素的神经生物学感兴趣的知名科学家、博士后和研究生聚集在一起。它将每隔一年举行一次，在美国和欧洲地点轮流举行。下一次会议将于 2007 年秋初在瑞士莱迪亚布勒雷举行。许多实验室正在进行的工作表明，内源性大麻素（endocannabinoids）在调节短期和长期可塑性、神经发育和神经保护方面发挥着重要作用。与此同时，越来越清楚的是，内源性大麻素与多种行为形式有关，包括对常见滥用药物的特定形式的奖励。最后，人们才刚刚开始认识到大麻素的广泛娱乐和治疗用途对内源性大麻素信号传导功效的影响。本次会议的目标是定期深入探索和整合这些关系，并确定未来几年大麻素领域最重要和最有价值的研究领域。要研究的主题的例子包括：内源性大麻素系统的药理学探针；内源性大麻素的合成和失活；大麻素受体和信号转导；大麻素与其他信号系统的相互作用；大麻素和短期和长期可塑性；大麻素和奖励：食物、性和厌恶；内源性大麻素参与神经元发育；长期使用大麻素后的适应性变化。