Indiana University Bloomington (IUB) Center for Cannabis, Cannabinoids, and Addiction (C3A)

印第安纳大学伯明顿分校 (IUB) 大麻、大麻素和成瘾中心 (C3A)

• 批准号: 10713089
• 负责人: Kenneth Mackie
• 金额: $ 167.47万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713089
• 关键词: Address; Affect; Age; Anatomy; Applications Grants; Behavioral; Biological; Biological Markers; Brain; Cannabinoids; Cannabis; Cell physiology; Chronic; Collaborations; Creativeness; Cultured Cells; Data; Data Storage and Retrieval; Dopamine; Drug Addiction; Drug abuse; Education; Endocannabinoids; Ensure; Fostering; Foundations; Functional Imaging; Funding; Goals; Grant; Home; Illinois; Image; Imaging Techniques; In Vitro; Indiana; Individual; Institution; Intake; Kentucky; Knowledge; Learning; Letters; Light; Lipids; Mass Spectrum Analysis; Measures; Mentors; Microscopy; Midwestern United States; Modality; Molecular; Mus; National Institute of Drug Abuse; Neuromodulator; Neurosciences; Ohio; Optics; Paper; Participant; Pathway interactions; Pattern; Pharmaceutical Preparations; Pilot Projects; Plasma; Population; Predictive Factor; Process; Productivity; Public Health; Publishing; Qualifying; Recording of previous events; Relapse; Research; Research Personnel; Resources; Running; STEM career; Sampling; Scanning; Scientist; Serotonin; Services; Signal Transduction; Slide; Specimen; Structure; Substance Use Disorder; Talents; Techniques; Technology; Thinking; Training; Underrepresented Populations; United States National Institutes of Health; Universities; West Virginia; Withdrawal; Work; addiction; awake; career; compulsion; data dissemination; equipment acquisition; experience; experimental study; high resolution imaging; imaging approach; imaging modality; in vivo; in vivo calcium imaging; innovation; interest; lipid mediator; microscopic imaging; multi-photon; multimodality; multiphoton imaging; multiphoton microscopy; nanoscale; non-drug; novel; novel strategies; operation; optical imaging; outreach; phytocannabinoid; preservation; prevent; programs; reconstruction; sensor; superresolution microscopy; tissue fixing; underserved minority; university student

Abstract We are proposing to establish the IU Bloomington Center for Cannabis, Cannabinoid, and Addiction (IUB-C3A) as a NIDA Core Center for Excellence to serve addiction researchers both in the central Midwest and across the nation. This Center will offer core services to further our understanding of fundamental brain processes leading to or following the use of addictive drugs, particularly cannabis. The IUB-C3A will consist of two service cores, a pilot project core, and an administrative core. The Administrative Core will provide a well- defined structure for efficient center management, for public outreach, for organizing the Center’s courses, as well as for preserving and making easily accessible the data generated by the Center’s scientists. The Bioactive Lipid Mediators Core (BLMC) will provide analytical service for detecting cannabinoids and other bioactive lipid mediators in biological samples and run a summer course directed towards underserved minority college students interested in STEM careers. The MultiScale Imaging Core (MSIC) will offer services and training across a range of light microscopic imaging modalities. The multiphoton resource of the MSIC will include training and access to longitudinal in vivo imaging of calcium and other sensors (e.g., neuromodulators such as endocannabinoids, dopamine, and serotonin) from very young ages as well as long-range pathway tracing in “cleared” brain specimens. The STORM/confocal resource of the MSIC will offer users the opportunity to perform correlative structure/function studies from the macro- to nanoscale level and will also offer courses on these techniques. Both cores will emphasize innovation and integration of their respective techniques, as outlined in the proposal. The Pilot Project Core will solicit pilot projects from C3A Affiliates and investigators outside of the drug abuse field and mentor them through the process of obtaining data and NIDA support for their research ideas. The PIs for the IUB-C3A have a long history of productive collaborations, including publishing more than sixty papers together and holding several MPI NIH grants. The IUB-C3A is conceptualized as a resource that will offer opportunities for other addiction investigators across the Central Midwest (Southern Illinois, Indiana, Kentucky, Ohio, and West Virginia), a region strongly affected by drug addiction, and across the nation. The IUB-C3A aims to increase diversity in addiction research through a combination of summer experiences and pilot project programs targeted to under-represented populations in neuroscience and addiction. A core goal of these programs is to bring talented individuals into the field of addiction research. We anticipate that they will apply creative directions, rigorous experimental approaches, and novel ways of thinking to a major public health problem. The strong support of Indiana University to this endeavor is evident by generous matching funds for both equipment purchases and our diversity programs. All of these factors predict that the IUB-C3A will become a regional and national resource for better understanding and developing treatments for addictive disorders and their consequences.

抽象的 我们提议建立印第安纳大学布卢明顿大麻、大麻素和成瘾中心 (IUB-C3A) 作为 NIDA 核心卓越中心，为中西部中部和各地的成瘾研究人员提供服务 该中心将提供核心服务，以加深我们对基本大脑过程的理解。 导致或使用成瘾药物（尤其是大麻）后，IUB-C3A 将由两个部分组成。 服务核心、试点项目核心和行政核心将提供良好的服务。 明确了有效的中心管理、公共宣传、组织中心课程的结构， 以及保存和轻松访问该中心科学家生成的数据。 生物活性脂质介质核心（BLMC）将为检测大麻素和其他物质提供分析服务 生物样本中的生物活性脂质介质，并针对服务不足的少数群体举办夏季课程 MultiScale Imaging Core (MSIC) 将向对 STEM 职业感兴趣的大学生提供服务和服务。 MSIC 的多光子资源将提供一系列光学显微成像模式的培训。 包括培训和获得钙和其他传感器（例如神经调节剂）的纵向体内成像 例如内源性大麻素、多巴胺和血清素）从很小的时候就开始以及长程途径 MSIC 的 STORM/共聚焦资源将为用户提供“清除”的大脑样本的追踪。 有机会进行从宏观到纳米尺度的相关结构/功能研究，并且还将 两个核心课程都将强调各自的创新和整合。 提案中概述的技术，试点项目核心将向 C3A 附属机构和机构征求试点项目。 药物滥用领域之外的调查人员，并通过获取数据和 NIDA 的过程对他们进行指导 IUB-C3A 的 PI 有着悠久的富有成效的合作历史， 包括共同发表 60 多篇论文并持有多项 MPI NIH 资助。 概念化为一种资源，将为中央的其他成瘾调查人员提供机会 中西部（伊利诺伊州南部、印第安纳州、肯塔基州、俄亥俄州和西弗吉尼亚州），受毒品影响严重的地区 IUB-C3A 旨在通过以下方式增加成瘾研究的多样性。 结合夏季经验和针对代表性不足人群的试点项目方案 这些项目的核心目标是将有才华的人带入神经科学和成瘾领域。 我们预计他们将应用创造性的方向、严格的实验方法、 印第安纳大学对此的大力支持。 我们的努力体现在设备采购和多元化计划方面的慷慨配套资金。 这些因素预测 IUB-C3A 将成为区域和国家资源，以更好地了解 开发成瘾性疾病及其后果的治疗方法。