Regenerative Engineering Training Program (RE-Training)

再生工程培训计划（RE-Training）

• 批准号: 10641321
• 负责人: Guillermo Antonio Ameer
• 金额: $ 10.56万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641321
• 关键词: Regenerative engineering; Training; Training Programs

Summary for the Regenerative Engineering Training Program A major health challenge that our society faces is premature death and morbidity associated with the shortage of healthy donor tissues or organs for transplantation and the limited regenerative capacity of our body due to serious injury or disease. Research that entails the convergence of disparate disciplines to create new frameworks, tools, and a new common language is positioned to better enable solutions to complex problems such as the aforementioned one. Regenerative engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and translational medicine to reconstruct or regenerate complex tissues and organs. The objective of this training program is to offer the curriculum and environment needed to train the next generation of convergence researchers that are versed in the development and use of regenerative engineering solutions. Specifically, program graduates will have the capacity to develop scientific, technical, and clinical knowledge and skills that will enable them to recognize and solve challenges associated with the restoration of tissue and organ function. Core innovative elements of the program include: 1) clinical immersion rotations to gain direct insight into organ failure and tissue reconstruction challenges that afflict patients and physicians; 2) a 3-member mentorship team that includes 1 clinical, 1 life/physical sciences, and 1 engineering faculty member; 3) internships at companies with product development expertise involving regenerative engineering; and 4) experiential courses to learn essential experimental techniques. The program, housed in the Center for Advanced Regenerative Engineering at Northwestern University, will be a joint effort involving diverse faculty from the schools of engineering, arts and sciences, and medicine. Northwestern University has a long history of transdisciplinary collaborations and has the resources and pedagogical tools to establish a unique national program to train new leaders. Trainees will be mentored by preceptors working in molecular and stem cell biology, nanotechnology, additive manufacturing, regenerative engineering, molecular biophysics, biomaterials, bioelectronics, surgery, and translational medicine. Examples of ongoing collaborations include programs for the regeneration of bladder, bone, blood vessels, pancreas, liver, kidney, skin, muscle, the immune system, and nerves. We propose to train 3 pre-doctoral trainees in year 1 and 6 trainees for each of years 2-5. Trainees will be selected from applicants in the department of Biomedical Engineering, including those from the medical scientist training program. We expect to produce the next generation of regenerative engineering thought leaders that are competent in convergence research aimed at tackling the aforementioned societal health challenges and improving patient outcomes.

再生工程培训计划的摘要 我们社会面临的重大健康挑战是与 缺乏健康供体组织或器官的移植和有限的再生能力 由于严重的伤害或疾病，我们的身体。研究需要不同学科的融合 为了创建新的框架，工具和新的通用语言可以更好地启用解决方案 诸如上述问题之类的复杂问题。再生工程是融合 高级材料科学，干细胞和发育生物学，物理科学和 转化医学以重建或再生复杂的组织和器官。这个目的 培训计划是提供培训下一代所需的课程和环境 精通再生工程发展和使用的融合研究人员 解决方案。具体而言，课程毕业生将有能力发展科学，技术和 临床知识和技能将使他们能够认识并解决与之相关的挑战 组织和器官功能的恢复。该计划的核心创新元素包括：1）临床 沉浸式旋转以直接深入了解器官衰竭和组织重建挑战 折磨患者和医生； 2）一个由3人组成的指导团队，其中包括1个临床，1个生命/身体 科学和1名工程教师； 3）在有产品开发的公司实习 涉及再生工程的专业知识； 4）学习必不可少的体验课程 实验技术。该计划位于高级再生工程中心 在西北大学，将是一项联合努力，涉及工程学院的多元化教师， 艺术与科学和医学。西北大学有跨学科的悠久历史 协作并拥有资源和教学工具，以建立独特的国家计划来 培训新领导人。学员将受到分子和干细胞生物学的受体的指导， 纳米技术，添加剂制造，再生工程，分子生物物理学，生物材料， 生物电子学，手术和翻译医学。正在进行的合作示例包括 膀胱，骨骼，血管，胰腺，肝脏，肾脏，皮肤，肌肉的再生程序 免疫系统和神经。我们建议在1年级和6名学员培训3名博士前学员 每年2 - 5年。学员将从生物医学系的申请人中选出 工程，包括医学科学家培训计划的工程。我们希望产生 下一代的再生工程思想领导者有能力 旨在应对上述社会健康挑战并改善患者的研究 结果。