Research Methods Core

研究方法核心

基本信息

批准号：
10459238
负责人：
Clemma Jacobsen Muller
金额：
$ 31.01万
依托单位：
WASHINGTON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10459238
关键词：
Aging Alaska Native Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American Indians Behavior Therapy Biometry Chippewa Clinical Clinical Trials Clinical Trials Cooperative Group Collaborations Communities Community Health Data Data Analytics Data Collection Diagnosis Disease Ensure Epidemiologist Epidemiology Ethnic group Evaluation Faculty Funding Goals Grant Health Health Personnel Health Status Health behavior Healthcare Healthy People 2020 High Prevalence Hypertension Indigenous Individual Infrastructure Intervention Studies Intervention Trial Lead Life Expectancy Life Style Logistics Measurable Measurement Measures Medicine Methodology Methods Minnesota Minority Native Hawaiian or Other Pacific Islander Native-Born Non-Insulin-Dependent Diabetes Mellitus Persons Physical activity Play Policies Population Prevalence Prevention Public Health Qualitative Research Race Reproducibility Research Research Design Research Methodology Research Personnel Research Project Grants Resource Allocation Resources Risk Role Sample Size Sampling Science Services Sleep Disorders Smoking Standardization Statistical Data Interpretation Training Trust United States National Institutes of Health Universities Validity and Reliability Washington Work base college community setting database design design evidence base experience flexibility genetic epidemiology health disparity health inequalities improved innovation instrument low socioeconomic status member mid-career faculty mild cognitive impairment professor racial and ethnic disparities randomized trial skills social

项目摘要

RESEARCH METHODS CORE: ABSTRACT Healthy People 2020 calls for research and policy to eliminate racial and ethnic disparities in health status, health behaviors, functional limitations, and healthcare use. Although progress has been made toward these goals, large disparities persist for American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders. These groups have a high prevalence of risk factors for Alzheimer’s disease and related dementias and are at greater risk than other groups for under diagnosis of these disorders. Accordingly, the Natives Engaged in Alzheimer’s Research Center will conduct community-based Alzheimer’s disease and related dementias studies within American Indian, Alaska Native, Native Hawaiian, and Pacific Islander populations using methods and instruments that yield accurate, reliable data. The Research Methods Core’s primary function is to collaborate with individual Research Projects and Cores, sharing expertise to improve the scientific function of each component of the Center. To be successful, our Research Projects and Cores require innovative designs with measurable, achievable objectives; efficient resource allocation; appropriate implementation; regular, meaningful evaluations; and appropriate statistical analyses. Accordingly, the Research Methods Core’s goals are to make the most efficient use of study resources by standardizing methods for measurement and analysis to the extent possible; to optimize internal and external study validity; and to ensure the relevance of inferential analyses for healthcare providers, policymakers, community leaders, and other key stakeholders. The Research Methods Core’s Specific Aims are to: 1) Integrate with each RP team and other Cores to provide state-of-the- art methodological support for sample size and power calculations, study design, sampling, and implementation; and proactively identify opportunities for disseminating best practices between Research Project teams and Cores, as well as for cross-study collaboration; 2) Maximize the scientific validity of the Research Projects by a) ensuring reliability and validity of study measures; b) standardizing methods for measurement, data collection, and database design to the extent possible; and c) ensuring the reproducibility and transparency of Research Project results; and 3) Apply a flexible and comprehensive quantitative and qualitative data analytic strategy that leverages transdisciplinary Research Methods Core faculty expertise to implement the most reproducible analyses for each Research Project’s Specific Aims. The Core will maximize scientific rigor while accommodating the logistical and methodological challenges that arise in real-world research endeavors. It will leverage both the skills of methodologists with years of experience working on multi-project grants, as well as numerous existing partnerships. The collaboration between the Research Methods Core, Research Projects, and Cores will play a critical role in ensuring that our work contributes to understanding and ameliorating Alzheimer’s disease and related dementias disparities in American Indians, Alaska Natives, and Native Hawaiians, and Pacific Islanders.

研究方法核心：摘要《健康人民 2020》呼吁开展研究和制定政策，消除健康状况、健康方面的种族和民族差异尽管在这些目标方面已经取得了进展，美洲印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民之间仍然存在巨大差异。阿尔茨海默病和相关痴呆症危险因素的患病率较高，并且患病率更高因此，当地人患有阿尔茨海默氏症的风险高于其他群体。研究中心将在以下范围内开展基于社区的阿尔茨海默病和相关痴呆症研究美洲印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民使用方法和产生准确、可靠数据的仪器研究方法核心的主要功能是协作。与单独的研究项目和核心，分享专业知识以提高每个研究项目和核心的科学功能为了取得成功，我们的研究项目和核心需要创新设计。可衡量、可实现的目标；有效的资源分配；有意义的评估；以及适当的统计分析。通过标准化测量和分析方法来最有效地利用研究资源尽可能优化内部和外部研究的有效性；为医疗保健提供者、政策制定者、社区领袖和其他主要利益相关者进行分析。方法核心的具体目标是： 1) 与每个 RP 团队和其他核心集成，以提供最先进的对样本量和功效计算、研究设计、抽样和实施的艺术方法论支持；并主动寻找在研究项目团队和研究项目团队之间传播最佳实践的机会核心以及交叉研究合作；2) 通过 a) 最大限度地提高研究项目的科学有效性确保研究措施的可靠性和有效性； b) 标准化测量、数据收集方法，尽可能地进行数据库设计；以及 c) 确保研究的可重复性和透明度项目结果；以及 3) 应用灵活且全面的定量和定性数据分析策略，利用跨学科研究方法核心教师的专业知识来实施最具可重复性的研究对每个研究项目的具体目标的分析将最大限度地提高科学严谨性，同时适应。它将利用现实世界研究工作中出现的后勤和方法挑战。具有多年多项目资助工作经验的方法学家的技能，以及许多现有的研究方法核心、研究项目和核心之间的合作将发挥重要作用。在确保我们的工作有助于理解和改善阿尔茨海默病和美洲印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民的相关痴呆症差异。