Analysis Core

分析核心

基本信息

批准号：
10207459
负责人：
Clemma Jacobsen Muller
金额：
$ 9.59万
依托单位：
WASHINGTON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10207459
关键词：
Affect Aging Alaska Native Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American American Indians Applications Grants Behavioral Biometry Catalogs Censuses Cerebrovascular Trauma Cognitive Colorado Communities Data Data Analytics Data Collection Data Set Development Diagnosis Elderly Ensure Epidemiologic Methods Evaluation Funding Future Goals Health Health Policy Health Services Health Status Health behavior Healthcare Healthy People 2020 High Prevalence Impaired cognition Instruction Knowledge Logistics Measurement Measures Medical center Mentors Mentorship Methodology Methods Minority National Institute on Aging Native Hawaiian Outcomes Research Pacific Island Americans Participant Pilot Projects Policies Population Populations at Risk Prevalence Procedures Public Health Qualitative Methods Questionnaire Designs Research Research Design Research Personnel Resources Running Sampling Scientist Statistical Data Interpretation Structure Subgroup Surveys Techniques Underrepresented Minority Universities Validity and Reliability Washington Work career cohort community based participatory research data management education research experience flexibility health disparity health economics human old age (65+)improved instrument interest member minority communities native elder programs psychologic racial and ethnic disparities research study social

项目摘要

ANALYSIS CORE ABSTRACT American Indians/Alaska Natives (AI/ANs) and Native Hawaiians/Pacific Islanders (NHPIs) have a high prevalence of risk factors for Alzheimer’s disease and related dementias (ADRD), including vascular brain injury and other cognitive impairments. Yet we have limited data on ADRD in AI/ANs and NHPIs; even reliable prevalence estimates are lacking. One barrier to remediating this lack of knowledge is the fact that existing methods and measures for identifying, diagnosing, and evaluating ADRD are often inappropriate for use with these populations, which experience unique social, cultural, and environmental influences on ADRD. Most available studies on ADRD contain far too few members of these populations to permit meaningful analysis of distinct population subgroups. Therefore, we will conduct studies with AI/AN and NHPI cohorts and datasets using methods and instruments that yield accurate, reliable data on topics relevant to ADRD. The Native Alzheimer’s Disease-related Resource Center in Minority Aging Research (RCMAR) emphasizes health disparities and ADRD as the focus of Pilot Studies led by early- or mid-career investigators RCMAR Scientists that will provide the experience and mentorship they need to contribute to a rapid expansion of the scope and quality of ADRD research with AI/ANs and NHPIs. The goal of the Analysis Core is to optimize the quality of Pilot Studies conducted by RCMAR Scientists. We draw on 20 years of experience with the Native Elder Research Center RCMAR, which is jointly run by the University of Colorado and Washington State University. We also benefit from collaborative relationships with investigators from Alzheimer’s Disease Centers. This Core will ensure that Pilot Studies make efficient use of study resources, apply methods that optimize validity, and yield findings with clear and meaningful inference to the larger population of interest. We will integrate diverse methods from epidemiology, biostatistics, health economics, health services and policy, and health outcomes research, and we will augment our robust quantitative capacity with exceptional experience in qualitative methods specific to underrepresented minority communities. Thus, the Specific Aims of the Analysis Core are to: 1) Collaborate with the Research Education Component to develop and implement methods to optimize the validity, inference, and generalizability of Pilot Studies and future funding applications; 2) Provide structured support and formal didactic instruction to RCMAR Scientists; and 3) Develop and critically evaluate a catalog of datasets containing information on the health of AI/ANs and NHPIs that can used by RCMAR Scientists and future ADRD Investigators. If ADRD is as prevalent in these groups as in Whites, we would expect more than 78,800 elderly AI/ANs and 18,000 elderly NHPIs to be affected. The size of this at-risk population underscores the substantial public health importance of the program we propose. Therefore, the work of the Analysis Core will maximize scientific rigor while accommodating the logistical and methodological challenges that not infrequently arise in real-world research with underrepresented communities.

分析核心摘要美洲印第安人/阿拉斯加原住民 (AI/AN) 和夏威夷原住民/太平洋岛民 (NHPI) 的死亡率较高阿尔茨海默病和相关痴呆症 (ADRD) 危险因素的普遍存在，包括血管性脑损伤然而，我们关于 AI/AN 和 NHPI 中 ADRD 的数据甚至是有限的；缺乏患病率估计是弥补这一知识缺乏的一个障碍。用于识别、诊断和评估 ADRD 的方法和措施通常不适合用于这些人群经历了独特的社会、文化和环境对 ADRD 的影响。现有的 ADRD 研究包含的这些人群的成员太少，无法进行有意义的分析因此，我们将使用 AI/AN 和 NHPI 队列和数据集进行研究。使用可产生与 ADRD 相关主题的准确、可靠数据的方法和仪器。少数族裔老龄化研究阿尔茨海默病相关资源中心 (RCMAR) 强调健康差异和 ADRD 是早期或中期职业研究人员 RCMAR 科学家领导的试点研究的重点这将为他们提供所需的经验和指导，以促进范围的迅速扩大和 AI/AN 和 NHPI 的 ADRD 研究质量分析核心的目标是优化 Pilot 的质量。我们利用 RCMAR 科学家 20 年的本土老年人研究经验进行了研究。 RCMAR 中心，由科罗拉多大学和华盛顿州立大学联合运营。该核心将受益于与阿尔茨海默病中心研究人员的合作关系。确保试点研究有效利用研究资源，应用优化有效性的方法，并产生成果我们将整合不同的方法，为更多感兴趣的人群提供清晰且有意义的推论。来自流行病学、生物统计学、卫生经济学、卫生服务和政策以及健康结果研究，我们将通过在特定定性方法方面的卓越经验来增强我们强大的定量能力因此，分析核心的具体目标是： 1) 合作。与研究教育部分一起开发和实施优化有效性、推理、试点研究和未来资助申请的普遍性；2) 提供结构化支持和正式支持向 RCMAR 科学家提供教学指导；以及 3) 开发并严格评估包含以下内容的数据集目录： RCMAR 科学家和未来 ADRD 可以使用的有关 AI/AN 和 NHPI 健康状况的信息如果 ADRD 在这些群体中像白人一样普遍，我们预计将有超过 78,800 名老年人 AI/AN 和 18,000 名老年 NHPI 受到影响这一高危人群的规模凸显了其巨大的规模。我们提出的计划对公共卫生的重要性因此，分析核心的工作将最大化。科学研究，同时适应经常出现的后勤和方法挑战对代表性不足的社区进行现实世界研究。