Population Based Research for Alzheimer's Innovation (POP BRAIN)

基于人群的阿尔茨海默病创新研究 (POP BRAIN)

• 批准号: 10199565
• 负责人: Kristine Yaffe
• 金额: $ 94.53万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10199565
• 关键词: Achievement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Award; Biological; Biometry; Caliber; Development; Discipline; Epidemiology; Ethnic Origin; Etiology; Fostering; Funding; Impaired cognition; Investigation; Lead; Leadership; Life Cycle Stages; Mentors; Mission; Pathway interactions; Physical activity; Population Heterogeneity; Population Research; Population Study; Positioning Attribute; Precision Health; Prevention; Prevention strategy; Public Health; Race; Research; Research Design; Research Personnel; Research Training; Resources; Risk; Risk Factors; Scientific Inquiry; Seminal; Traumatic Brain Injury; cardiovascular risk factor; career; career development; cohort; experience; health disparity; improved; innovation; insight; multidisciplinary; next generation; novel; population health; pre-clinical; precision medicine; programs; sex; sleep quality; social health determinants

ABSTRACT Dr. Yaffe's background and accomplishments make her ideally positioned for the proposed R35 Leadership Award in ADRD focusing on the AD/ADRD Research Implementation Milestones for population studies, precision medicine and health disparities. Over the past 20 years, the PI and her team have led a research program in the epidemiology of ADRD. Within this broad theme, Dr. Yaffe has focused on studies aimed at identifying risk factors, particularly those that are modifiable (a key component of the exposome), for pre- clinical cognitive decline and ADRD. Her team has led seminal investigations on physical activity, sleep quality, cardiovascular risk factors, traumatic brain injury and other key risk factors. In order to achieve the next platform of research and training in line with the Population Studies Milestone, the team will create an exciting multidisciplinary program entitled, the UCSF Population Based Research for Alzheimer's Innovation or Pop- BRAIN. Dr. Yaffe has assembled an outstanding multidisciplinary leadership group to advance ADRD population health along a highly innovative and impactful roadmap for discovery and next generation of researchers' development. The R35 mechanism is an ideal platform to enhance Dr. Yaffe's previous line of investigation in population health but also to pivot to greater emphasis on three themes that are nicely aligned with Milestone 1.B: 1) a life-course approach to risk factors and novel analytic approaches to studying the life- course exposome, 2) emphasis on diverse populations and how the exposome and life-course exposures may differ across groups (by race/ethnicity and sex) and provide insight into risk mechanisms and 3) and the relatively unexplored inter-relationship of the exposome, social determinants of health and biological pathways of ADRD. We will conduct these studies using established and novel analytic approaches for investigation in several cohorts that the investigators lead or have extensive experience with. Implementation of this innovative line of investigation will highlight new strategies for prevention, underscore the underpinnings for health disparities in risk of ADRD and offer new insights to the life-course etiology of ADRD. In an equally important mission, the Pop-BRAIN program will foster the careers of junior investigators from a variety of disciplines focused on population health for ADRD. This will involve new resources as well as leveraging and harmonizing existing but disparate programs at UCSF. The program will provide mentoring, didactics, research design and biostatistics guidance, pilot funding and career development activities across several departments in a unified hub dedicated to population health. Due to the caliber of her achievements and deep commitment to improving public health through rigorous scientific inquiry and developing the next generation of investigators, Dr. Yaffe and her Pop-BRAIN multidisciplinary team of experts are in an ideal position to embrace a Leadership Award and deliver on the Milestone in Population Health.

抽象的 Yaffe博士的背景和成就使她成为拟议R35领导的理想位置 ADRD颁发的授予关注广告/ADRD研究实施的人群研究里程碑， 精确医学和健康差异。在过去的20年中，PI和她的团队领导了一项研究 ADRD流行病学的计划。在这个广泛的主题中，Yaffe博士专注于针对的研究 识别风险因素，尤其是那些可修改的因素（展览会的关键组成部分） 临床认知能力下降和ADRD。她的团队领导了有关体育锻炼，睡眠质量的开创性调查， 心血管危险因素，创伤性脑损伤和其他关键危险因素。为了实现下一个 与人口研究里程碑一致的研究和培训平台，团队将创造一个令人兴奋的 多学科计划，标题为“基于UCSF的基于阿尔茨海默氏症的创新或流行的研究 脑。 Yaffe博士已经组建了一个杰出的跨学科领导力小组，以推动ADRD 人口健康沿着高度创新和有影响力的路线图和下一代 研究人员的发展。 R35机制是增强Yaffe博士以前的一行的理想平台 人口健康的调查，但也要更加重视三个非常顺利的主题 具有里程碑1.b：1）一种生命课程方法，用于研究生活的新型分析方法 - 课程展览，2）强调各种人群，以及如何展示剥离和生活方式的暴露 各个群体（根据种族/种族和性别）有所不同，并提供了对风险机制的见解，以及3） 相对尚未探索的健康和生物途径的社会决定因素的相互关系 Adrd。我们将使用已建立和新颖的分析方法进行这些研究，以进行研究 调查人员领导或拥有丰富经验的几个队列。实施这种创新 调查线将重点介绍预防的新策略，强调了健康的基础 ADRD风险的差异，并为ADRD的生活课程病因提供了新的见解。在同样重要的 任务，流行脑计划将培养各种学科的初级调查员的职业 专注于ADRD的人口健康。这将涉及新资源以及利用和协调 UCSF的现有但不同的程序。该计划将提供指导，教学，研究设计和 统一的几个部门的生物统计学指导，试点资金和职业发展活动 集线器致力于人口健康。由于她的成就的能力和对改善的深厚承诺 通过严格的科学询问和发展下一代调查人员Yaffe博士的公共卫生 她的流行脑多学科专家团队处于接受领导奖的理想位置 并实现人口健康的里程碑。