Chronic Effects of Neurotrauma Consortium (CENC) Epidemiology Study

神经创伤联盟 (CENC) 流行病学研究的慢性影响

• 批准号: 9278103
• 负责人: Kristine Yaffe
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278103
• 关键词: Accidents; Address; Adverse effects; Afghanistan; Age; Alcohols; Architecture; Archives; Caring; Cessation of life; Chronic; Clinical; Comorbidity; Conflict (Psychology); Data; Data Sources; Databases; Dementia; Diagnosis; Disease; Distress; Evaluation; Foundations; Future; Goals; Healthcare Systems; Impaired cognition; Individual; Injury; Intervention; Investigation; Iraq; Knowledge; Life Cycle Stages; Medical; Medical Records; Mental Depression; Mental Health; Mental disorders; Methods; Migraine; Military Personnel; Movement Disorders; National Institute of Neurological Disorders and Stroke; Nervous System Trauma; Neurodegenerative Disorders; Outcome; Overdose; Pain; Patient Care; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; Prevention strategy; Preventive Intervention; Public Health; Registries; Rehabilitation therapy; Research Infrastructure; Resources; Risk; Seizures; Sensory; Series; Services; Sleep; Subgroup; Time; Trauma; Traumatic Brain Injury; Veterans; Violence; adverse outcome; behavioral health; cohort; combat; data structure; epidemiology study; high risk; improved; insight; mild traumatic brain injury; mortality; neurosensory; novel; physical conditioning; repository; resilience

The primary objective of this project is to capitalize on a variety of existing data sources by integrating and analyzing them in novel ways to answer key questions related to the chronic effects of mild traumatic brain injury (mTBI) in Veterans over time. Although prior studies have found that moderate and severe TBI are associated with a variety of adverse clinical outcomes, the effects of mTBI are less well understood. We propose to address this gap in knowledge through four complimentary Specific Aims. In Aim 1, we propose to examine the association between mTBI and important shorter-term clinical outcomes such as accidents and injuries in Veterans from recent conflicts in Iraq and Afghanistan, focusing on identifying factors associated with resilience and the potential benefits of adequate treatment. In Aim 2, we propose to expand these analyses to include Veterans from all eras and to study longer-term clinical outcomes including neurosensory disorders and mortality, focusing on the potential confounding effects of comorbid medical conditions and the impact of their treatment. In Aim 3, we propose to identify different trajectories of mTBI-related comorbid burden, with the goal of identifying factors associated with being in low and high distress trajectories. Finally, in Aim 4, we propose to lay the groundwork for future analyses using more detailed and unified mTBI data by developing the groundwork to create a National CENC Data Repository (NCDR). Together, these Aims will advance our knowledge of the effects of mTBI on important clinical outcomes in Veterans of all ages and eras in a highly efficient manner and will provide insight into potential strategies for prevention and intervention.

该项目的主要目的是通过集成和 以新颖的方式分析它们，以回答与轻度创伤性大脑的慢性影响有关的关键问题 随着时间的流逝，退伍军人受伤（MTBI）。尽管先前的研究发现中度和重度TBI是 与多种不良临床结果相关的是，MTBI的作用知之甚少。我们 建议通过四个免费的特定目标来解决知识的差距。在AIM 1中，我们建议 检查MTBI与重要短期临床结果（例如事故）和 伊拉克和阿富汗最近发生冲突的退伍军人受伤，重点是识别相关的因素 具有韧性和适当治疗的潜在益处。在AIM 2中，我们建议将这些扩展 分析包括所有时代的退伍军人并研究包括神经感觉的长期临床结果 疾病和死亡率，重点关注合并症的潜在混杂作用和 他们的治疗的影响。在AIM 3中，我们建议确定与MTBI相关的合并症的不同轨迹 负担，目的是确定与处于低和高遇险轨迹相关的因素。最后，在 AIM 4，我们建议使用更详细和统一的MTBI数据为将来的分析奠定基础 开发基础工作以创建国家cenc数据存储库（NCDR）。这些目标将在一起 促进我们对MTBI对所有年龄段和时代退伍军人重要临床结果的影响的了解 以高度有效的方式，将洞悉预防和干预的潜在策略。

项目成果

Health Phenotypes and Neurobehavioral Symptom Severity Among Post-9/11 Veterans With Mild Traumatic Brain Injury: A Chronic Effects of Neurotrauma Consortium Study.

• DOI: 10.1097/htr.0000000000000574
• 发表时间: 2021-01-01
• 期刊: JOURNAL OF HEAD TRAUMA REHABILITATION
• 影响因子: 2.4
• 作者: Bouldin, Erin D.;Swan, Alicia A.;Norman, Rocio S.;Tate, David F.;Tumminello, Christa;Amuan, Megan E.;Eapen, Blessen C.;Wang, Chen-Pin;Trevino, Amira;Pugh, Mary Jo
• 通讯作者: Pugh, Mary Jo