A mechanistic and dyadic approach to identify how interpersonal conscientiousness supports cognitive health and lowers risk of dementia

采用机械和二元方法来确定人际责任感如何支持认知健康并降低痴呆风险

• 批准号: 10739837
• 负责人: Angelina R Sutin
• 金额: $ 230.02万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10739837
• 关键词: Achievement; Address; Adult; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Behavior; Behavioral; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Complex; Couples; Dementia; Diabetes Mellitus; Discipline; Disease Progression; Ecological momentary assessment; Environment; Etiology; Family; Genetic; Goals; Health; Healthcare Systems; Hypertension; Impaired cognition; Impairment; Individual; Inflammation; Intervention; Interviewer; Knowledge; Life; Life Cycle Stages; Literature; Loneliness; Longevity; Measures; Mental Depression; Modeling; National Institute on Aging; Nerve Degeneration; Obesity; Onset of illness; Outcome; Pathway interactions; Personal Satisfaction; Personality Traits; Physical activity; Physiological; Prevalence; Prevention; Prevention strategy; Process; Psychological Factors; Public Health; Research; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Sampling; Self-control as a personality trait; Services; Sleep; Smoking; Stress; Testing; Theoretical model; Time; Well in self; Work; cognitive function; cognitive performance; cognitive task; critical period; dementia risk; discounting; effective intervention; healthy aging; human old age (65+); member; middle age; novel; prevent; protective effect; protective factors; psychologic; recruit; satisfaction; therapy development; trait

Project Summary The burden of Alzheimer’s Disease (AD) takes a significant toll on the individual living with dementia, their families and communities, and the healthcare system. Without effective intervention and prevention strategies, the prevalence of AD is expected to more than double over the next 30 years. It is critical to identify protective factors that can be leveraged for more effective prevention before the onset of the disease. Conscientiousness is a personality trait that is associated consistently with better health outcomes, which extends to dementia: Conscientiousness is one of the most replicated psychological factors that is protective against cognitive impairment. Most work on Conscientiousness has focused on its agentic aspects (e.g., self-control, achievement striving). Conscientiousness, however, has a distinct interpersonal component that is often overlooked in the relation with health in general and cognition in particular. This interpersonal component – Interpersonal Conscientiousness – defined as either responsibility or dutifulness, is protective against dementia, an effect that has replicated in three independent samples. In addition, its protective association with dementia is independent of the agentic components of this trait and extends to cognitive function prior to dementia. Interpersonal Conscientiousness is thus a robust and novel psychological factor that is a promising target of intervention for healthier cognitive outcomes in older adulthood. The objective of this proposal is to provide much needed stage 0 evidence that is necessary for intervention development. Specifically, this research aims to identify the clinical/physiological, behavioral, psychological, and relational mechanisms through which Interpersonal Conscientiousness leads to better cognitive outcomes. The proposed research addresses these mechanisms and cognition as typically measured in lab settings and the daily expression of these mechanisms and momentary cognitive performance measured with ecological momentary assessment in everyday life. It seeks to identify the pathways through which Interpersonal Conscientiousness protects cognition and promotes better daily cognitive function across a critical period of the lifespan – midlife and the transition to old age (ages 40-70) – a period particularly relevant for prevention because it is generally before the onset of neurodegeneration. In addition, this research addresses actor and partner effects within committed relationships to test whether the protective effect of Interpersonal Conscientiousness extends from one member of the couple to the other. This work will lead to new knowledge on how Interpersonal Conscientiousness promotes healthier cognitive aging and will point to new prevention and intervention targets for promoting healthier cognitive aging across adulthood to support better outcomes in older adulthood.

项目摘要 阿尔茨海默氏病（AD）的伯恩对痴呆症的人造成了重大损失 家庭和社区以及医疗保健系统。没有有效的干预和预防策略， 在未来30年内，AD的患病率预计将增加两倍以上。识别受保护是至关重要的 疾病发作之前，可以利用可利用更有效预防的因素。尽职尽责 是一种与更好的健康结果有关的人格特征，它扩展到痴呆症： 尽职尽责的心理因素之一是受到认知的保护 损害。大多数关于尽职的工作都集中在其代理方面（例如，自我控制，成就 努力）。但是，尽职尽责，具有独特的人际关系组件，在 尤其是与健康的关系，尤其是认知。这个人际关系组件 - 人际关系 尽职尽责 - 被定义为责任或尽职尽责，受到保护，免受痴呆症的保护，这种效果是 已在三个独立样本中复制。此外，它与痴呆的保护性关联是独立的 在痴呆之前，该性状的代理成分延伸到认知功能。 因此 老年人的认知结果更健康。该建议的目的是提供急需的阶段 0的证据是干预开发所必需的。具体来说，这项研究旨在确定 人际关系的临床/生理，行为，心理和关系机制 认真性会带来更好的认知结果。拟议的研究解决了这些机制 和认知通常在实验室环境中测量以及这些机制的每日表达和 瞬时的认知表现通过日常生活中的生态瞬时评估来衡量。它寻求 确定人际认真性保护认知并更好地促进认知的途径 在寿命的关键时期 - 中年和过渡到老年的每日认知功能（40-70岁） - 一个与预防特别相关的时期，因为它通常是在神经退行性发作之前。 此外，本研究还针对有统治关系中的演员和伴侣效应，以测试是否是否 人际关系的保护作用从这对夫妇的一个成员延伸到另一个成员。这 工作将导致有关人际认真度如何促进更健康的认知衰老的新知识 并将指出新的预防和干预目标，以促进成年期更健康的认知衰老 支持较早的成年后更好的结果。