Prenatal and Early Life Antecedents of Personality: An Intergenerational Lifespan Approach

人格的产前和早期生命前因：代际寿命方法

• 批准号: 10152495
• 负责人: Angelina R Sutin
• 金额: $ 64.22万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10152495
• 关键词: Address; Adolescence; Adult; Age; Aging; Alcohol abuse; Alzheimer' s Disease; Alzheimer' s disease risk; Behavioral; Biological; Biological Factors; Biological Markers; Biological Testing; Buffers; Cardiovascular Diseases; Child; Childhood; Clinical; Cognition; Cognitive; Cognitive aging; Conceptions; Consequentialism; Crime; Data; Data Collection; Data Sources; Development; Disease; Early Intervention; Economics; Environment; Environmental Risk Factor; Exposure to; Functional disorder; Genetic; Gestational Diabetes; Goals; Health; Health behavior; Hypertension; Impaired cognition; Individual; Individual Differences; Inflammation; Informal Social Control; Intervention; Knowledge; Life; Life Cycle Stages; Link; Longevity; Longitudinal Studies; Maternal Health; Measures; Mediating; Mediator of activation protein; Mental Depression; Modeling; Neighborhoods; Neurotic Disorders; Outcome; Outcomes Research; Parents; Pathway interactions; Personal Satisfaction; Personality; Personality Development; Personality Traits; Play; Pregnancy; Process; Research; Risk; Risk Factors; Role; Shapes; Smoking; Temperament; Testing; Theoretical model; Time; Work; base; cognitive development; cognitive function; cohort; disorder risk; early childhood; early life adversity; emotion regulation; fetal programming; healthy aging; human old age (65+); improved; inflammatory marker; intergenerational; offspring; prenatal; psychologic; racial diversity; social deprivation; social health determinants; socioeconomics; theories; trait; young adult

Project Summary. This research takes an intergenerational lifespan perspective to the development of trait psychological functioning. There are well-documented connections between Conscientiousness and Neuroticism and aging- related outcomes: Individuals who score higher in Conscientiousness and lower in Neuroticism have lower risk of Alzheimer’s disease and greater longevity. The association between these traits and better health begins early in life and persist across the lifespan. Early interventions to promote healthier trait development will lead to broad improvements in health and well-being and ultimately better aging outcomes. Yet, little is known about the early environmental origins of these traits that would be promising targets of intervention. Likewise, relatively little is known about how biological factors contribute to trait development across the lifespan. The present research brings together three established longitudinal studies of well-characterized cohorts to identify prenatal and childhood environmental factors (broadly construed) that contribute to the development of personality, the biological mediators of these associations, and the dynamics between prenatal/childhood factors and personality on a consequential health outcome – the development and aging of cognitive functioning across the lifespan. Together, these three cohorts cover conception through older adulthood: The Longitudinal Study of Australian Children covers pregnancy through age 12, the Avon Longitudinal Study of Parents and Children covers pregnancy through young adulthood, and the Healthy Aging in Neighborhoods of Diversity across the Life Span covers middle through older adulthood. This research addresses three specific aims: (1) To identify maternal prenatal behavioral and clinical antecedents of temperament and personality traits and to test biological markers as one mechanism through which prenatal factors contribute to trait psychological functioning, (2) To identify childhood neighborhood antecedents of trait psychological functioning in childhood, adolescence, and adulthood and to test biological markers as one mechanism through which neighborhood factors contribute to trait psychological functioning, and (3) To test whether personality traits mediate and/or moderate the relation between the prenatal/childhood environment and cognitive functioning across the lifespan. The outcomes of this research will lead to new knowledge on the origins of the traits most relevant for healthy aging and suggest promising new targets for intervention.

项目摘要。 这项研究对特质心理的发展具有代际寿命的观点 功能。认真性与神经质与衰老之间存在据可查的联系。 相关结果：在认真度和较低的神经质中得分较高的个人具有较低的风险 阿尔茨海默氏病和更长的寿命。这些特征与更好的健康之间的关联开始了。 在生命的早期，贯穿整个生命。早期干预措施以促进更健康的特质发展将领导 对健康和福祉的广泛改善，并最终改善衰老结果。但是，对 这些特征的早期环境起源将被保证是干预的目标。同样地， 关于生物学因素如何促进整个生命周期的性状发展，知之甚少。 目前的研究汇集了三项针对良好特征的纵向研究，以识别 产前和儿童期环境因素（广泛建构），有助于发展 个性，这些关联的生物介体以及产前/儿童之间的动态 因素和性格上的健康结果 - 认知的发展和衰老 在整个生命周期中运作。这三个队列一起涵盖了旧的成年概念： 对澳大利亚儿童的纵向研究涵盖了12岁的怀孕，这是雅芳的纵向研究 父母和孩子涵盖了成年期间的怀孕，以及在社区的健康衰老 整个寿命的多样性涵盖了中期至较早的成年。这项研究解决了三个特定的 目的：（1）确定孕产妇的产前行为和温度和人格的临床前因 特征和测试生物标记作为一种机制 心理功能，（2）确定童年时期的特质心理功能 在童年时期，青少年和成年，并测试生物标记作为一种机制 邻里因素有助于特质心理功能，（3）测试人格特征是否 调解和/或调节产前/儿童期环境与认知功能之间的关系 整个生命周期。这项研究的结果将导致有关特征的起源的新知识 与健康的衰老相关，并建议有希望的新目标进行干预。

项目成果

Personality traits and physical functioning: a cross-sectional multimethod facet-level analysis.

• DOI: 10.1186/s11556-020-00251-9
• 发表时间: 2020-11-24
• 期刊: European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity
• 作者: Kekäläinen T;Terracciano A;Sipilä S;Kokko K
• 通讯作者: Kokko K

Is personality associated with dementia risk? A meta-analytic investigation.

• DOI: 10.1016/j.arr.2021.101269
• 发表时间: 2021-05
• 期刊: Ageing research reviews
• 影响因子: 13.1
• 作者: Aschwanden D;Strickhouser JE;Luchetti M;Stephan Y;Sutin AR;Terracciano A
• 通讯作者: Terracciano A

Multidimensional Assessment of Subjective Well-Being and Risk of Dementia: Findings from the UK Biobank Study.

主观幸福感和痴呆症风险的多维评估：英国生物银行研究的结果。

• DOI: 10.1007/s10902-022-00613-3
• 发表时间: 2023
• 期刊: Journal of happiness studies
• 影响因子: 4.6
• 作者: Zhu,Xianghe;Luchetti,Martina;Aschwanden,Damaris;Sesker,AmandaA;Stephan,Yannick;Sutin,AngelinaR;Terracciano,Antonio
• 通讯作者: Terracciano,Antonio

Neuroticism and white matter hyperintensities.

神经质和白质高信号。

• DOI: 10.1016/j.jpsychires.2023.07.026
• 发表时间: 2023
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Terracciano,Antonio;Cenatus,Bertin;Zhu,Xianghe;Karakose,Selin;Stephan,Yannick;Marcolini,Sofia;DeDeyn,PeterP;Luchetti,Martina;Sutin,AngelinaR
• 通讯作者: Sutin,AngelinaR

Parental Educational Attainment and Offspring Subjective Well-being and Self-Beliefs in Older Adulthood.

父母的教育程度和后代的主观幸福感和成年期的自信。

• DOI: 10.1016/j.paid.2018.01.023
• 发表时间: 2018
• 期刊: Personality and individual differences
• 影响因子: 4.3
• 作者: Sutin,AngelinaR;Stephan,Yannick;Terracciano,Antonio
• 通讯作者: Terracciano,Antonio