The Impact of Affect Regulatory Mechanisms and Binge Eating on Drug Recovery

影响调节机制和暴食对药物恢复的影响

• 批准号: 8699381
• 负责人: Nisha Gottfredson O'Shea
• 金额: $ 15.53万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699381
• 关键词: Abstinence; Adult; Affect; Affective; Alcohol or Other Drugs use; Amygdaloid structure; Animal Model; Behavior; Behavioral; Binge Eating; Binge eating disorder; Brain; Client; Communities; Comorbidity; Complement; Coping Skills; Cues; Data Analyses; Data Collection; Development; Diagnosis; Diet Records; Disease; Drug Addiction; Drug usage; Eating; Eating Behavior; Eating Disorders; Electronics; Epidemiologic Studies; Epidemiology; Faculty; Fatty acid glycerol esters; Feeling; Food; Genetic; Goals; Gold; Health; Hyperphagia; Illicit Drugs; Impulsivity; Individual; Individual Differences; Intake; Intervention; Investigation; K-Series Research Career Programs; Lead; Learning; Link; Literature; Measures; Mediating; Mentorship; Methodology; Methods; Modeling; Nature; Negative Reinforcements; Neurobiology; Nucleus Accumbens; Nutritional; Opiate Addiction; Opiates; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Perception; Personality; Persons; Pharmaceutical Preparations; Population; Population Process; Prefrontal Cortex; Prevention program; Recovery; Relapse; Research; Research Training; Rewards; Risk; Sampling; Self-control as a personality trait; Signal Transduction; Social support; Stress; Substance Addiction; Substance Use Disorder; System; Target Populations; Testing; Time; Tobacco use; Training; Weight; addiction; career; coping; craving; design; dopamine system; drug craving; drug relapse; endogenous opioids; experience; follow-up; high risk; meetings; non-drug; public health relevance; stressor; sugar; trait; treatment center; treatment program

DESCRIPTION (provided by applicant): Accumulating evidence increasingly supports a strong and multifaceted association between drug dependence and binge eating. Epidemiological investigations confirm high comorbidity between binge eating and substance use disorders; animal models reveal that addiction-like behaviors generalize across substances (including food); and neurobiological studies reveal common reward pathways for both food and illicit drugs. To better define the nature of this association, the current proposal examines daily behavioral associations between the most commonly abused drug among treatment populations, namely opiates, and binge eating behaviors. Specifically, I will investigate how abstinence from opiates among individuals recovering from addiction is associated with affect-driven binge eating, and how these dysregulated eating patterns are longitudinally associated with risk for opiate lapse and relapse. My research aims are to: 1) establish an ideal assessment system for quantifying daily caloric and nutritional intake and binge eating behavior in individuals recovering from opiate addiction; 2) test whether the relationship between negative affect and binge eating differs for individuals recovering from opiate addiction and demographically-matched controls; 3) identify time- specific (e.g., stress) and person-specific (e.g., personality) factors that exacerbate affect-driven binge eating as moderated by addiction status; and 4) test the effects of various coping strategies, and particularly the practice of affet-driven binge eating, on the longitudinal risk for relapse among those in recovery from opiate addiction. To accomplish these aims, I will study a minimum of N = 106 participants from two treatment facilities for drug addiction and N = 35 demographically comparable healthy controls from a community sample in the geographic vicinity of the treatment centers. Participants will respond to electronic signals three times daily over fourteen consecutive days by answering questions about drug use and cravings, negative affect, and eating behaviors occurring during the day. Individuals recovering from addiction will also be assessed every two weeks over 24 months to determine ongoing risk for relapse, substance use and other health outcomes. By integrating my proposed research plan with a plan to receive formal training and mentorship from faculty with expertise in affective models of drug use, the treatment of drug addiction, binge eating, and the neurobiology of addiction, the proposed Career Development Award complements my background in quantitative methodology by providing training I need to develop an independent and productive line of research dedicated to understanding the co-occurrence of addictive and binge eating behaviors, particularly in relationship to affect dysregulation. The research and training that I propose will lead to the submission of an R01 proposal that will provide a transition to an independent research career and serve to inform clinicians and clients about the ways in which binge eating influences recovery efforts for individuals in treatment for opiate use disorder.

描述（由申请人提供）：越来越多的证据越来越多地支持药物依赖和暴饮暴食之间存在强大且多方面的关联。流行病学调查证实暴饮暴食和物质使用障碍之间存在高度共病；动物模型表明，类似成瘾的行为普遍存在于各种物质（包括食物）中；神经生物学研究揭示了食物和非法药物的共同奖励途径。为了更好地定义该协会的性质，当前的提案每天都会进行审查 治疗人群中最常滥用的药物（即阿片类药物）与暴饮暴食行为之间的行为关联。具体来说，我将研究从成瘾中恢复的个体对阿片类药物的戒断如何与情感驱动的暴饮暴食相关，以及这些失调的饮食模式如何与阿片类药物戒断和复发的风险纵向相关。我的研究目标是：1）建立一个理想的评估系统，量化阿片成瘾康复者的每日热量和营养摄入量以及暴食行为； 2）测试从阿片成瘾中恢复的个体和人口统计学匹配的对照组中，负面情绪与暴食之间的关系是否有所不同； 3）确定特定时间（例如压力）和特定个人（例如性格）因素，这些因素会加剧由成瘾状态调节的情感驱动的暴饮暴食； 4）测试各种应对策略，特别是情绪驱动的暴饮暴食，对阿片类成瘾康复者的纵向复发风险的影响。为了实现这些目标，我将研究来自两个毒瘾治疗机构的至少 N = 106 名参与者，以及来自治疗中心附近社区样本的 N = 35 名人口统计学可比的健康对照者。参与者将在连续十四天内每天对电子信号做出三次反应，回答有关白天发生的药物使用和渴望、负面影响和饮食行为的问题。戒毒者还将在 24 个月内每两周接受一次评估，以确定复发、药物滥用和其他健康结果的持续风险。通过将我提出的研究计划与接受正式培训和指导的计划相结合，这些培训和指导来自具有吸毒情感模型、吸毒成瘾治疗、酗酒等方面专业知识的教师。 饮食和成瘾的神经生物学，拟议的职业发展奖通过提供培训来补充我在定量方法方面的背景，我需要开发独立且富有成效的研究路线，致力于了解成瘾和暴食行为的同时发生，特别是在关系中影响失调。我提议的研究和培训将导致提交 R01 提案，该提案将提供向独立研究职业的过渡，并告知临床医生和客户暴食如何影响接受阿片类药物使用治疗的个人的康复工作紊乱。