PROTEOMICS SHARED RESOURCE

蛋白质组学共享资源

• 批准号: 8340104
• 负责人: BRIAN J DRUKER
• 金额: $ 6.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-20 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340104
• 关键词: Acetylation; Applications Grants; Binding; Biological; Cancer Center Support Grant; Cancer Etiology; Cancer Patient; Cells; Cerebrospinal Fluid; Complex; Data; Disease; Dissociation; Early Diagnosis; Electron Transport; Funding; Health Sciences; Individual; Informatics; Institutes; Instruction; Label; Liquid substance; Malignant Neoplasms; Mass Spectrum Analysis; Modification; Oregon; Patients; Phosphorylation; Post-Translational Protein Processing; Productivity; Proteins; Proteomics; Proteomics Shared Resource; Relative (related person); Research; Research Personnel; Saliva; Sampling; Serum; Speed; Stable Isotope Labeling; Subcellular Fractions; Techniques; Technology; Tissues; Universities; Urine; Wages; Work; Writing; anticancer research; effective therapy; improved; mass spectrometer; member; tool

The Proteomics Shared Resource provides modern tools of mass spectrometry to Knight Cancer Institute members so that they may determine the identity, abundance, and modifications occurring in proteins, the building blocks of the cell. These analyses are crucial to understanding the cause of cancer and devising improved treatments for the disease, since changes in proteins occur in all forms of cancer. Support will be used to partially fund salaries of five staff and four state-of-the-art mass spectrometers to assist Knight investigators studying cancer-causing changes in proteins, including phosphorylation, acetylation, changes in abundance and altered binding to other proteins. A wide array of informatics tools and expertise will also be provided to Knight members to increase their research productivity. The results from the Proteomics Shared Resource will be used to better treat cancer patients by providing earlier diagnosis of the disease and discovering more effective treatments that are personalized for individual patients.

蛋白质组学共享的资源为骑士癌症研究所成员提供了现代的质谱工具，以便他们可以确定蛋白质中发生的身份，丰度和修饰。这些分析对于理解癌症的原因并设计了改善该疾病的治疗方法至关重要，因为蛋白质的变化发生在各种形式的癌症中。支持将是 用于部分资助五名员工和四个最先进的质谱仪的薪水，以帮助研究蛋白质引起癌症变化的骑士研究人员，包括磷酸化，乙酰化，丰度变化和与其他蛋白质的结合改变。还将向骑士成员提供各种信息学工具和专业知识，以提高其研究生产力。蛋白质组学的结果 共享资源将通过提供对疾病的较早诊断并发现针对个别患者个性化的更有效治疗方法来更好地治疗癌症患者。