The Kentucky ECHO Pediatric IDeA Research Center (KE-PIRC)

肯塔基州 ECHO 儿科 IDeA 研究中心 (KE-PIRC)

• 批准号: 10683291
• 负责人: Lori Ann Devlin-Phinney
• 金额: $ 43.04万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683291
• 关键词: Academic Medical Centers; Acceleration; Address; Adolescent; Adult; Airway Disease; Alcohol consumption; Appalachian Region; Area; Child; Child Health; Child health care; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Communities; Development; Diabetes Mellitus; Disease; Drug abuse; Education; Educational Status; Environment; Environmental Health; Etiology; Faculty; Family; Feedback; Fetal Development; Funding; Generations; Goals; Health; Health Benefit; Healthcare; Heart Diseases; High Prevalence; Individual; Infant; Institution; Intervention; Kentucky; Leadership; Malignant neoplasm of lung; Mentors; Mentorship; Multi-Institutional Clinical Trial; Neonatal; Neurologist; Obesity; Occupational Exposure; Outcome; Participant; Patients; Pediatric Hospitals; Perinatal; Physicians; Population; Population Heterogeneity; Preventive; Primary Care; Process; Provider; Refugees; Research; Research Infrastructure; Research Personnel; Resources; Rural; Rural Community; Rural Population; Scientist; Site; Smoking; Stroke; System; Talents; Teacher Professional Development; Time; Training; Training and Education; Underrepresented Minority; Underserved Population; United States National Institutes of Health; Universities; Urban Community; Vulnerable Populations; Work; autism spectrum disorder; biomedical referral center; care outcomes; career; cohort; community engagement; community partnership; ethnic minority; fetal; improved; innovation; member; next generation; novel strategies; nutrition; outreach program; patient population; pediatrician; postnatal; programs; racial minority; recruit; rural area; rural underserved; senior faculty; skills; success; underserved area; urban underserved

PROJECT SUMMARY/ABSTRACT As a predominantly rural state, Kentucky leads the nation in many pediatric and adult chronic and environmentally-related diseases and ‘ranks nationally’ in low educational achievement. These adverse factors combine to make Kentuckians especially unhealthy residents with a high prevalence of obesity, diabetes, smoking, alcohol use, heart disease, stroke, lung cancer, etc. Many of these diseases are environmentally related to poor nutrition, obesity, smoking, drug abuse, and work-place exposures. Kentucky also leads the nation in the percentage of pediatric populations with special health care needs. Prior work has shown that most adult diseases have their origin in childhood and some begin during fetal development, making childhood the ideal time for intervention with the goal of improving health outcomes into adulthood. Improving healthcare outcomes and wellness in children is contingent on expanding and sustaining high quality clinical research that includes diverse populations. Pediatricians at the University of Louisville (UofL) with our Healthcare Partners serve a highly diverse patient population that includes the rural and urban poor, a unique Appalachian community, refugees, and numerous ethnic minorities. To better serve this population, we propose to build upon our current programs, expand our bidirectional community engagement efforts, collaborate with other institutions on pediatric clinical trials through the ECHO IDeA Pediatric Clinical Trials Network, and collaborate with ECHO cohort, INBRE, and CTSA sites to advance healthcare for children. Education and training of local and regional faculty and staff is critical to sustain this initiative. The Kentucky ECHO-Pediatric IDeA Research Center (KE-PIRC), as part of the IDeA States Pediatric Clinical Trials Network, will make it possible for 1) rural and underserved infants, children and adolescents to participate in clinical research; 2) junior investigators to be trained in clinical research and community engagement, improve the health of both children and adults in Kentucky through this research, and develop their academic career; and 3) the development of a regional network of partners to sustain this clinical research initiative. The five primary focus areas are 1) pre-, peri- and postnatal outcomes; 2) neurodevelopmental; 3) upper and lower airway disease; 4) obesity; and 5) positive health. These primary focus areas are highly prevalent in Kentucky; therefore, KE-PIRC will enable strengthening current collaborations and accelerate the development of new networks within the state through bidirectional community engagement and feedback to support pediatric clinical research. Through these efforts, we aim to improve the health outcomes of Kentucky children and adults and establish a local and national sustainable pediatric clinical research workforce.

项目摘要/摘要 作为一个主要是农村国家，肯塔基州在许多儿科和成人慢性病中领导该国 与环境相关的疾病和“全国范围内”的教育成就。这些不利因素 结合使用肯塔基人，特别是不健康的居民，肥胖症，糖尿病，糖尿病患病率很高 吸烟，饮酒，心脏病，中风，肺癌等。其中许多疾病在环境上是 与营养不良，肥胖，吸烟，药物滥用和工作场所暴露有关。肯塔基州也带领 在有特殊医疗保健需求的儿科人群的百分比中。先前的工作表明 大多数成人疾病起源于童年，在胎儿发育期间有些开始，使童年 干预的理想时间，目的是将健康结果改善成年。 改善儿童的医疗保健成果和健康，取决于扩大和维持高 质量临床研究，包括潜水员人群。路易斯维尔大学（UOFL）的儿科医生 与我们的医疗合作伙伴一起服务于高度多样化的患者人群，其中包括粗糙和城市穷人， 独特的阿巴拉契亚社区，难民和众多少数民族。为了更好地为这个人群服务，我们 提议以我们当前的计划为基础，扩大我们的双向社区参与工作， 通过回声创意小儿临床试验与其他机构在儿科临床试验上合作 网络，并与Echo COHORT，INBRE和CTSA站点合作，以推动儿童的医疗保健。 对地方和地区教职员工的教育和培训对于维持这一倡议至关重要。 肯塔基州回声研究中心（KE-PIRC），作为思想状态的一部分儿科临床 试验网络将使1）可能的婴儿，儿童和青少年不得不 参加临床研究； 2）初级调查人员将接受临床研究和社区的培训 通过这项研究，参与，改善肯塔基州儿童和成人的健康，并发展 他们的学术生涯； 3）建立一个伙伴的区域网络，以维持这种临床 研究计划。五个主要重点区域是1）产后，周日和产后结局； 2） 神经发育； 3）上和下气道疾病； 4）肥胖； 5）积极健康。这些主要 焦点区域在肯塔基州非常普遍。因此，ke-pirc将能够加强电流 通过双向协作并加速州内新网络的发展 社区参与和反馈，以支持小儿临床研究。通过这些努力，我们的目标是 改善肯塔基儿童和成人的健康成果，并建立地方和国家可持续性 小儿临床研究人员。

项目成果

Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity.

• DOI: 10.1007/s40272-021-00460-4
• 发表时间: 2021-09
• 期刊: PEDIATRIC DRUGS
• 影响因子: 3.7
• 作者: Maharaj, Anil R.;Wu, Huali;Zimmerman, Kanecia O.;Muller, William J.;Sullivan, Janice E.;Sherwin, Catherine M. T.;Autmizguine, Julie;Rathore, Mobeen H.;Hornik, Chi D.;Al-Uzri, Amira;Payne, Elizabeth H.;Benjamin, Daniel K., Jr.;Hornik, Christoph P.
• 通讯作者: Hornik, Christoph P.