Abdominal adipose tissue depots and cardiometabolic disease risk in postmenopausal women

绝经后女性腹部脂肪组织库和心脏代谢疾病风险

• 批准号: 9906162
• 负责人: Andrew Owen Odegaard
• 金额: $ 24.83万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906162
• 关键词: Abdomen; Address; Adipose tissue; Age; Atrial Fibrillation; Basic Science; Benign; Body Composition; Body fat; Cardiovascular Diseases; Clinic; Clinical; Clinical Research; Congestive Heart Failure; Coronary heart disease; Deposition; Diet; Dietary intake; Disease; Disease Outcome; Dual-Energy X-Ray Absorptiometry; Dyslipidemias; Epidemiology; Ethnic Origin; Event; Functional disorder; Gold; Hypertension; Imaging Techniques; Insulin Resistance; Intervention; Intra-abdominal; Knowledge; Longitudinal cohort; Magnetic Resonance Imaging; Measurement; Measures; Metabolic; Methods; Minority; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Pattern; Peripheral arterial disease; Physical activity; Play; Population Research; Positioning Attribute; Postmenopause; Prevention; Radiation; Research; Research Personnel; Resources; Risk; Role; Sample Size; Sampling; Scanning; Sleep; Sleep disturbances; Slice; Stroke; Subcutaneous Tissue; Technology; Thinness; Time; Validation; Visceral; Visit; Woman; Women' s Health; X-Ray Computed Tomography; abdominal fat; cardiometabolic risk; cardiometabolism; cohort; cost; disorder prevention; disorder risk; evidence base; experience; follow-up; insight; interest; lumbar vertebra bone structure; new technology; prospective; research study; sleep pattern; standard measure; subcutaneous; waist circumference

PROJECT SUMMARY Accumulating basic, clinical, and population research suggests that high amounts of abdominal fat, particularly visceral adipose tissue (VAT) in the intra-abdominal depot, plays a crucial role in the pathophysiology of cardiometabolic diseases (i.e. type 2 diabetes (T2D), cardiovascular diseases (CVD) and stroke). This research has elegantly described the intimate nature of VAT as a powerful metabolic driver of insulin resistance, dyslipidemia, and hypertension. It also suggests that total body fat, and more specifically subcutaneous adipose tissue (SAT), may be relatively less important or even benign in the pathophysiology of cardiometabolic disease. Despite this burgeoning framework of knowledge, much remains unknown about the relationship between abdominal VAT and SAT levels with incident cardiometabolic disease events – a critical gap in the evidence base since further insight resulting from research on this topic would have major implications related to the importance of body composition and obesity in cardiometabolic disease prevention. The central reason for the bottleneck in the evidence base has been feasibility. Researchers and clinicians have had to rely on imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) to measure specific adipose tissue depots. Issues such as cost, radiation, and availability have made these methods impractical in the clinic and for large research studies; and the few studies which have incorporated these technologies may have limited sample size, or have not accrued enough follow up time and events to adequately address the topic. However, there is an efficient and economical solution to this problem via the application of new technology that quantifies abdominal VAT and SAT from existing Dual Energy X-Ray Absorptiometry (DXA) scans. This technology has demonstrated strong validity with gold-standard measures of abdominal adipose tissue depots from MRI and CT scans. Therefore, we propose to apply this novel technology to the existing Women's Health Initiative (WHI) DXA cohort to quantify abdominal VAT and SAT from existing DXA scans. This proposal will create a valuable, new, minority enriched, analytic longitudinal cohort that will utilize repeated DXA measurements in the WHI at baseline (N=10,607), year 3 (N=8,939), year 6 (N=8,239), and year 9 (N=4,595) to address essential questions on the topic of abdominal adiposity/body composition, and cardiometabolic disease risk in postmenopausal women as they age. This project capitalizes on a rich scientific resource and will provide new and advanced results that will delineate the importance of abdominal adipose tissue depots in cardiometabolic disease risk and the potential for targeted interventions and prevention efforts.

项目摘要 累积基本，临床和人口研究表明，腹部脂肪量大多，尤其是 腹腔内沉积中的内脏脂肪组织（VAT）在病理生理学中起着至关重要的作用 心脏代谢疾病（即2型糖尿病（T2D），心血管疾病（CVD）和中风）。这 研究优雅地描述了增值税作为胰岛素的强大代谢驱动力的亲密性质 抗药性，血脂异常和高血压。这也表明总体脂肪，更具体地说 皮下脂肪组织（SAT），在病理生理学的重要性相对较小，甚至不那么良性 心脏代谢疾病。尽管有一个了解的野蛮框架，但关于 腹部增值税与SAT水平与事件心脏代谢疾病事件之间的关系 - 关键 自从该主题研究引起的进一步见解以来，证据基础的差距将具有重要的 与身体成分和肥胖症在心脏代谢疾病预防中的重要性有关的含义。 证据基础中瓶颈的主要原因是可行性。研究人员和临床医生 不得不依靠成像技术，例如计算机断层扫描（CT）和磁共振成像 （MRI）测量特定的脂肪组织沉积物。成本，辐射和可用性等问题 这些方法在诊所和大型研究中不切实际；还有一些研究 合并这些技术的样本量可能有限，或者没有积累足够的随访时间，并且 充分解决该主题的事件。但是，有一个有效且经济的解决方案 通过应用量化腹部增值税的新技术，并从现有双能X射线 吸收法（DXA）扫描。这项技术表现出了强大的有效性，并通过金标准的测量值 MRI和CT扫描中的腹部脂肪组织沉积。因此，我们建议应用这本小说 现有妇女健康计划（WHI）DXA队列的技术，以量化腹部增值税和SAT 来自现有的DXA扫描。该建议将创造一个有价值的，新的，少数族裔的纵向纵向 在基线时（n = 10,607），第3年（n = 8,939）的WHI中使用重复的DXA测量的队列 6（n = 8,239），以及9年级（n = 4,595），以解决有关腹部肥胖/身体主题的基本问题 绝经后妇女的成分和心脏代谢疾病随着年龄的增长而风险。该项目大写 在丰富的科学资源上，将提供新的和高级的结果，以描述 心脏代谢疾病风险中的腹部脂肪组织沉积物和靶向干预措施的潜力 和预防努力。