Human Adenovirus-36 Antibody Status and Development of Childhood Obesity

人类腺病毒36抗体状况与儿童肥胖的发展

• 批准号: 8464340
• 负责人: Andrew Owen Odegaard
• 金额: $ 11.4万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-22 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8464340
• 关键词: 12 year old; Adenoviruses; Adipose tissue; Adolescent; Adult; African American; Age; Animals; Antibodies; Area; Biological Assay; Body fat; Child; Childhood; Communities; Complex; Cross-Sectional Studies; Data; Databases; Demographic Accounting; Deposition; Development; Diet; Energy Intake; Energy Metabolism; Environmental Risk Factor; Epidemic; Etiology; Fibrinogen; Freezing; Genetic; Glucose; Gold; Growth; Health; Human; Human Adenoviruses; Infection; Insulin; Life Cycle Stages; Life Style; Lipids; Measures; Metabolic; Molecular; National Heart, Lung, and Blood Institute; Non obese; Obesity; Outcome; Participant; Physical activity; Prevalence; Public Health; Research; Risk; Risk Factors; Sampling; Serum; Testing; Time; United States; Viral; blood lipid; cohort; girls; insight; novel; obesity in children; prospective; psychosocial; socioeconomics; trend

DESCRIPTION (provided by applicant): The prevalence of childhood and adolescent obesity in the United States has approximately tripled over the last 30 years, with similar trends observed globally. This is a significant public health issue as children and adolescents who are obese are at greater risk for a spectrum of health problems in the near and long term. Substantial scientific effort has been devoted to understanding the causes of childhood obesity, and the overall obesity epidemic. Even with this significant endeavor there is an incomplete understanding of the etiology of obesity throughout the life-course. What can be concluded is that the causes of obesity are heterogeneous and likely result from a complex interplay between factors related to energy intake and expenditure, genetics, and environmental factors. Despite this incomplete understanding the vast majority of research has continued to focus on factors related to energy intake and expenditure and to a lesser extent genetics, socioeconomic and psychosocial aspects; the scientific community is acknowledging that research efforts need to be more comprehensive beyond these factors One burgeoning area of obesity related research has examined an infectious contributor, specifically human adenovirus-36 (Adv36). Animal studies have consistently shown that infection with Adv36 leads to excess adipose tissue deposition and obesity, while cellular and molecular studies have provided plausible underlying mechanisms. The studies in humans are limited to date. A handful of cross-sectional studies in adults have examined whether seropositivity for Adv36 infection is associated with obesity. Some showed a significantly greater proportion of Adv36 seropositivity in obese vs. non-obese participants, whereas others found no difference in prevalence of infection. On the other hand, the few cross-sectional studies that have examined this question in children all found a greater prevalence of Adv36 seropositivity in obese vs. non- obese children. These human studies are intriguing but limited by the lack of temporality, small samples, and simple statistical approaches. Therefore, we are proposing a more thorough study. Specifically, in 839 black and white girls from the NHLBI National Growth and Health Study (NGHS) we will assess the seropositivity of Adv36 at two time points using the gold standard assay. We will integrate this new measure into the rich database from the study and carry out comprehensive statistical analyses examining aspects of Adv36 infection with measures of childhood obesity.

描述（由申请人提供）：过去 30 年来，美国儿童和青少年肥胖的患病率大约增加了两倍，全球也观察到类似的趋势。这是一个重大的公共卫生问题，因为肥胖的儿童和青少年在短期和长期内面临一系列健康问题的风险更大。大量的科学努力致力于了解儿童肥胖的原因以及总体肥胖流行情况。即使做出了这一重大努力，对整个生命过程中肥胖的病因学的了解仍然不完全。可以得出的结论是，肥胖的原因是多种多样的，并且可能是与能量摄入和消耗、遗传和环境因素相关的因素之间复杂的相互作用造成的。尽管了解不完全，绝大多数研究仍然关注与能量摄入和消耗相关的因素，以及较小程度的遗传、社会经济和社会心理方面；科学界承认，除这些因素外，研究工作需要更加全面。肥胖相关研究的一个新兴领域已经检查了一种传染性因素，特别是人类腺病毒 36 (Adv36)。动物研究一致表明，Adv36 感染会导致过多的脂肪组织沉积和肥胖，而细胞和分子研究则提供了合理的潜在机制。对人类的研究仅限于迄今为止。一些针对成人的横断面研究已经检验了 Adv36 感染的血清阳性是否与肥胖相关。一些研究显示，与非肥胖参与者相比，肥胖参与者的 Adv36 血清阳性比例明显更高，而其他研究发现感染率没有差异。另一方面，在儿童中检验这个问题的少数横断面研究都发现，与非肥胖儿童相比，肥胖儿童中 Adv36 血清阳性的患病率更高。这些人类研究很有趣，但由于缺乏时间性、样本量小和统计方法简单而受到限制。因此，我们建议进行更彻底的研究。具体来说，我们将使用金标准检测在两个时间点评估来自 NHLBI 国家生长与健康研究 (NGHS) 的 839 名黑人和白人女孩的 Adv36 血清阳性情况。我们将把这一新的测量方法整合到丰富的研究数据库中，并通过儿童肥胖测量方法进行全面的统计分析，检查 Adv36 感染的各个方面。