Human Adenovirus-36 Antibody Status and Development of Childhood Obesity

人类腺病毒36抗体状况与儿童肥胖的发展

• 批准号: 8705003
• 负责人: Andrew Owen Odegaard
• 金额: $ 7.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-22 至 2014-12-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8705003
• 关键词: 12 year old; Adenoviruses; Adipose tissue; Adolescent; Adult; African American; Age; Animals; Antibodies; Area; Biological Assay; Body fat; Child; Childhood; Communities; Complex; Cross-Sectional Studies; Data; Databases; Demographic Accounting; Deposition; Development; Diet; Energy Intake; Energy Metabolism; Environmental Risk Factor; Epidemic; Etiology; Fibrinogen; Freezing; Genetic; Glucose; Gold; Growth; Health; Human; Human Adenoviruses; Infection; Insulin; Life Cycle Stages; Life Style; Lipids; Measures; Metabolic; Molecular; National Heart, Lung, and Blood Institute; Non obese; Obesity; Outcome; Participant; Physical activity; Prevalence; Public Health; Research; Risk; Risk Factors; Sampling; Serum; Testing; Time; United States; Viral; blood lipid; cohort; girls; insight; novel; obesity in children; prospective; psychosocial; socioeconomics; trend

DESCRIPTION (provided by applicant): The prevalence of childhood and adolescent obesity in the United States has approximately tripled over the last 30 years, with similar trends observed globally. This is a significant public health issue as children and adolescents who are obese are at greater risk for a spectrum of health problems in the near and long term. Substantial scientific effort has been devoted to understanding the causes of childhood obesity, and the overall obesity epidemic. Even with this significant endeavor there is an incomplete understanding of the etiology of obesity throughout the life-course. What can be concluded is that the causes of obesity are heterogeneous and likely result from a complex interplay between factors related to energy intake and expenditure, genetics, and environmental factors. Despite this incomplete understanding the vast majority of research has continued to focus on factors related to energy intake and expenditure and to a lesser extent genetics, socioeconomic and psychosocial aspects; the scientific community is acknowledging that research efforts need to be more comprehensive beyond these factors One burgeoning area of obesity related research has examined an infectious contributor, specifically human adenovirus-36 (Adv36). Animal studies have consistently shown that infection with Adv36 leads to excess adipose tissue deposition and obesity, while cellular and molecular studies have provided plausible underlying mechanisms. The studies in humans are limited to date. A handful of cross-sectional studies in adults have examined whether seropositivity for Adv36 infection is associated with obesity. Some showed a significantly greater proportion of Adv36 seropositivity in obese vs. non-obese participants, whereas others found no difference in prevalence of infection. On the other hand, the few cross-sectional studies that have examined this question in children all found a greater prevalence of Adv36 seropositivity in obese vs. non- obese children. These human studies are intriguing but limited by the lack of temporality, small samples, and simple statistical approaches. Therefore, we are proposing a more thorough study. Specifically, in 839 black and white girls from the NHLBI National Growth and Health Study (NGHS) we will assess the seropositivity of Adv36 at two time points using the gold standard assay. We will integrate this new measure into the rich database from the study and carry out comprehensive statistical analyses examining aspects of Adv36 infection with measures of childhood obesity.

描述（由申请人提供）：在过去的30年中，美国的儿童和青少年肥胖症的患病率大约增加了两倍，在全球范围内观察到类似的趋势。这是一个重大的公共卫生问题，因为肥胖的儿童和青少年在近期和长期遇到健康问题的风险更大。大量的科学努力致力于理解儿童肥胖症的原因以及整体肥胖症的流行。即使有这项重大努力，对整个生命过程中肥胖的病因也有不完全的理解。可以得出的结论是，肥胖的原因是异质的，可能是由于与能量摄入和支出，遗传学和环境因素有关的因素之间的复杂相互作用而引起的。尽管有这种不完全理解，但绝大多数研究继续关注与能量摄入和支出有关的因素，以及较小程度的遗传学，社会经济和社会心理方面；科学界承认，研究工作必须超越这些因素，而肥胖相关的研究研究了一个迅速发展的领域，研究了一个传染性贡献者，特别是人类腺病毒36（Adv36）。动物研究一直表明，ADV36感染会导致脂肪组织的过量沉积和肥胖，而细胞和分子研究则提供了合理的潜在机制。迄今为止，人类的研究仅限于人类。成人的少数横断面研究检查了Adv36感染的血清阳性是否与肥胖有关。一些人在肥胖与非肥胖参与者中的ADV36血清阳性比例明显更大，而另一些则发现感染的患病率没有差异。另一方面，在儿童中检查了这个问题的少数横断面研究发现，肥胖与非肥胖儿童的Adv36血清阳性率更高。这些人类研究很有趣，但由于缺乏时间性，小样本和简单的统计方法而受到限制。因此，我们提出了一项更彻底的研究。具体而言，在NHLBI国家增长与健康研究（NGHS）的839名黑白女孩中，我们将使用黄金标准测定法在两个时间点评估Adv36的血清阳性。我们将从研究中将这一新措施整合到丰富的数据库中，并进行全面的统计分析，以检查Adv36感染的各个方面，并采用儿童肥胖症的措施。