Assessing impact of drinking water exposure to GenX (hexafluoropropylene oxide dimer acid) in the Cape Fear River Basin, North Carolina

评估北卡罗来纳州开普菲尔河流域饮用水暴露于 GenX（六氟环氧丙烷二聚酸）的影响

• 批准号: 9537950
• 负责人: JANE HOPPIN
• 金额: $ 31.14万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-11-01 至 2019-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9537950
• 关键词: Acids; Address; Adult; Animals; Area; Back; Biological; Blood; Blood specimen; Chemicals; Child; Cholesterol; Cities; Clinical; Clinical Chemistry Tests; Commerce; Communication; Communities; Consumption; County; Ensure; Environment; Enzymes; Exposure to; Fright; Future; Health; Health Personnel; Human; Immunosuppression; Individual; Lipids; Liver; Maintenance; Malignant Neoplasms; Measurable; Measures; Metabolic; Methods; North Carolina; Outcome; Oxides; Paper; Participant; Physicians; Plants; Poly-fluoroalkyl substances; Process; Production; Protocols documentation; Public Health; Publishing; Questionnaires; Recording of previous events; Reporting; Research Personnel; Rivers; Sampling; Scientist; Serum; Source; Testing; Thyroid Function Tests; Thyroid Hormones; Time; Toxic effect; Ulcerative Colitis; United States Dept. of Health and Human Services; Universities; Urinalysis; Urine; Vertebrates; Water; Woman; Work; adverse pregnancy outcome; base; boys; design; dimer; drinking water; epidemiology study; exposed human population; girls; human data; liver function; meetings; member; men; recruit; thyroid disruption; water sampling; water treatment; web site

GenX (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate) is a short-chain perfluoroalkyl substance (PFAS) generated in the production of non-stick coatings. This chemical has been detected in the Cape Fear River in North Carolina. The Cape Fear River serves as a drinking water source for ~300,000 residents in the lower Cape Fear River basin, including residents of New Hanover, Brunswick, and Pender Counties. In June 2017, community concern about this chemical in drinking water resulted in multiple public meetings of citizens trying to obtain information about their potential exposure and resulting health effects associated with consumption of drinking water. As a result of community concern, the chemical plant has reportedly stopped discharging GenX into the river. However, it is still measurable in finished drinking water and community concern still exists. This project is designed to help address community questions about GenX exposure and health effects. Little is known about how GenX is stored in the body, the toxicity of GenX, or how long the chemical will remain in the environment. To address these questions, we plan to conduct a community-based study of lower Cape Fear River area residents who are served by public utility water. We will work with community partners of the Cape Fear River Watch and the New Hanover County Department of Health to help identify a representative sample of residents, to collect biological samples, and to keep the community informed about what is known about GenX and what the study finds. We plan to recruit ~400 Wilmington area residents (100 men, 100 women, 100 boys, 100 girls) to provide blood, urine, and drinking water samples and to complete a questionnaire on their water use history. We plan to analyze blood, urine, and drinking water for GenX and related chemicals; blood and urine samples will also be used for clinical tests (lipid profile, thyroid function, liver function, and urinalysis). All results from the study will be shared with both the community as a whole and each individual participant. We will have a community advisory panel for the study to help advise about study protocols, methods of reporting back results to participants, and provide guidance on ongoing or new community concerns about GenX. This project leverages the expertise of NC State’s Center for Human Health and the Environment to respond to an emerging community concern.

genx（2,3,3,3-Tetrafluoro-2-（己二氟丙氧基） - 丙酸）是一种短链完整氟烷基 在不粘涂层的生产中产生的物质（PFA）。已检测到该化学物质 在北卡罗来纳州的开普敦恐惧河中。开普敦恐惧河是饮用水源 下开普恐惧河流域的〜30万居民，包括新汉诺威的居民， 不伦瑞克和彭德县。 2017年6月，社区对这种化学饮酒的关注 水导致了多次公民会议，试图获取有关其的信息 潜在的暴露和与饮用水消费相关的健康影响。作为 由于社区关注的结果，据报道，化学厂已停止将Genx排入 河。但是，在完成的饮用水和社区关注中仍然可以衡量 存在。该项目旨在帮助解决有关GenX暴露和健康的社区问题 效果。关于GenX如何存储在体内，Genx的毒性或多长时间 该化学物质将保留在环境中。为了解决这些问题，我们计划进行 公用事业公司服务的基于社区的较低恐惧河地区居民 水。我们将与Cape Cape Fear River Watch和New Hanover县的社区合作伙伴合作 卫生部有助于确定代表性的居民样本，以收集生物学 样本，并向社区宣布有关GENX的知识以及研究的知识 找到。我们计划招募约400个威尔明顿地区居民（100名男性，100名女性，100个男孩，100个女孩） 提供血液，尿液和饮用水样本，并在水上完成问卷 使用历史记录。我们计划为Genx和相关化学物质分析血液，尿液和饮用水； 血液和尿液样品也将用于临床测试（脂质剖面，甲状腺功能， 肝功能和尿液分析）。研究的所有结果将与两个社区共享 整体和每个参与者。我们将有一个社区咨询小组进行研究 为了帮助有关研究方案的建议，向参与者报告结果的方法，以及 提供有关持续或新社区对GENX的关注的指导。这个项目利用了 NC州人类健康中心和环境的专业知识，以应对新兴 社区关注。