Maintaining and enriching the Infants Environmental Health Study (ISA)

维持和丰富婴儿环境健康研究（ISA）

• 批准号: 10205066
• 负责人: JANE HOPPIN
• 金额: $ 29.4万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205066
• 关键词: 2,4-Dichlorophenoxyacetic Acid; 7 year old; Address; Affect; Age; Agriculture; Air; Allergic; Area; Banana; Biological; Biological Markers; Biological Monitoring; Birth; Body Weight Changes; Books; Canada; Chemical Exposure; Chemicals; Child; Child Development; Chlorpyrifos; Code; Cohort Studies; Collaborations; Communities; Community Developments; Complex; Computer software; Costa Rica; Country; County; Data; Data Analytics; Data Collection; Data Management Resources; Data Reporting; Data Security; Data Set; Development; Documentation; Ecosystem; Education; Environmental Exposure; Environmental Health; Environmental Monitoring; Epidemiology; Exhalation; Exposure to; Funding; Future; General Population; Goals; Government; Growth; Hair; Health; Health Promotion; Health Status; Height; Human; Individual; Infant; Infrastructure; International; Knowledge; Labor Unions; Longitudinal cohort; Longterm Follow-up; Lung diseases; Maintenance; Manganese; Measures; Medical History; Modeling; Mothers; Nail plate; National Institute of Environmental Health Sciences; Nature; Nitrous Oxide; Nongovernmental Organizations; Online Systems; Outcome; Oxidative Stress; Participant; Pesticides; Policy Maker; Primary Schools; Private Sector; Production; Prospective cohort study; Protocols documentation; Questionnaires; Reporting; Research; Research Personnel; Research Project Grants; Resources; Retrieval; Sampling; Schools; Specimen; Statistical Data Interpretation; Time; United States; Update; Validation; Water; Weight; Woman; air monitoring; base; civil society; cohort; community engagement; community planning; cypermethrin; data access; data integrity; data management; data sharing; epidemiology study; exposed human population; improved; mancozeb; meetings; member; neurobehavioral; neurobehavioral test; neurodevelopment; operation; outreach program; pesticide exposure; programs; respiratory; respiratory health; rural underserved; tool; underserved area; underserved community; urinary; vector control; web site; young woman

Understanding the potential health effects of pesticides is difficult due to the episodic nature of exposure and the lack of individual’s knowledge regarding their personal exposure. The ISA Cohort study in Costa Rica is a community-based cohort of 350 mothers and their now 5-7 year old children living in Matina County, Costa Rica, a banana growing region for the country. These individuals are exposed to a variety of different chemicals as used in agriculture, mainly banana production, vector control, and pasture, including mancozeb, chlorpyrifos, pyrimethanil, thiabendazole, cypermethrin, and 2,4-D. Exposure to these and other pesticides, as well as manganese (a component of mancozeb), has been measured through biological and environmental monitoring of the cohort for the past six years. To date, investigators have been funded to assess growth and neurobehavioral outcomes associated with pre- and post-natal exposure to these pesticides, oxidative stress, and respiratory and allergic outcomes in mothers and children. The ISA cohort provides critical information to assess the potential human health effects of pesticides as these same pesticides are used in the US as well as Costa Rica. This proposal will strengthen the ISA cohort for the long-term by: 1) creating a more consistent outreach program to inform the cohort members as well as their communities, civil society organizations, governmental organizations and private sector about study findings on a regular basis; 2) updating participant medical history including neurobehavioral and respiratory outcomes and collecting biological samples every two years; 3) establishing more complete data documentation to allow for easier collaboration and data sharing; 4) providing long term specimen storage in Costa Rica; and 5) enhancing understanding of pesticide exposure in the cohort and community through aggregation of available exposure data for cohort participants, validation of urinary biomarkers with environmental sampling, air monitoring of pesticides at primary schools situated in the study area, and statistical approaches to manage the complex exposure data. This proposal focuses on a community-engaged model to enhance long term follow-up by collecting and report data relevant to the community on a routine basis.

由于农药的偶发性，了解农药对健康的潜在影响很困难。 ISA 队列中的个人暴露情况以及个人对其个人暴露情况缺乏了解。 哥斯达黎加的一项以社区为基础的队列研究由 350 名母亲及其现在 5-7 岁的孩子组成 这些人居住在哥斯达黎加的马蒂纳县，该国的香蕉种植区。 接触农业中使用的各种不同的化学品，主要是香蕉生产， 病媒控制和牧场，包括代森锰锌、毒死蜱、嘧霉胺、噻菌灵、 氯氰菊酯和 2,4-D 接触这些农药和其他农药以及锰（一种成分）。 代森锰锌），已通过对队列的生物和环境监测进行测量 迄今为止，研究人员已获得资助来评估生长和神经行为。 与产前和产后接触这些农药、氧化应激和 ISA 队列提供了关键的母亲和儿童的呼吸道和过敏结果。 评估农药对人类健康的潜在影响的信息，因为这些农药 在美国和哥斯达黎加使用该提案将加强 ISA 队列。 长期而言：1）创建一个更加一致的外展计划来通知队列成员 作为他们的社区、民间社会组织、政府组织和私营部门 定期了解研究结果；2) 更新参与者的病史，包括 神经行为和呼吸系统结果并每两年收集一次生物样本 3) 建立更完整的数据文档，以便更轻松地协作和数据共享； 4) 在哥斯达黎加提供长期标本储存；5) 加强对农药的了解 通过汇总队列的可用暴露数据，在队列和社区中暴露 参与者，通过环境采样验证尿液生物标志物，空气监测 研究区域内小学的农药残留情况，以及管理农药残留的统计方法 该提案侧重于社区参与模型以增强长期效果。 通过定期收集和报告与社区相关的数据进行后续行动。