Maintaining and enriching the Infants Environmental Health Study (ISA)

维持和丰富婴儿环境健康研究（ISA）

基本信息

批准号：
10443768
负责人：
JANE HOPPIN
金额：
$ 28.81万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10443768
关键词：
2,4-Dichlorophenoxyacetic Acid 7 year old Address Affect Age Agriculture Air Allergic Area Banana Biological Biological Markers Biological Monitoring Birth Body Weight Changes Books Canada Chemical Exposure Chemicals Child Child Development Chlorpyrifos Code Cohort Studies Collaborations Communities Community Developments Complex Computer software Costa Rica Country County Data Data Analytics Data Collection Data Management Resources Data Reporting Data Security Data Set Development Documentation Ecosystem Education Environmental Exposure Environmental Health Environmental Monitoring Epidemiology Exhalation Exposure to Funding Future General Population Goals Government Growth Hair Health Health Promotion Health Status Height Human Individual Infant Infrastructure International Knowledge Labor Unions Longitudinal cohort Longterm Follow-up Maintenance Manganese Measures Medical History Modeling Mothers Nail plate National Institute of Environmental Health Sciences Nature Nitrous Oxide Nongovernmental Organizations Online Systems Outcome Oxidative Stress Participant Persons Pesticides Policy Maker Primary Schools Private Sector Production Prospective cohort study Protocols documentation Questionnaires Reporting Research Research Personnel Research Project Grants Resources Respiratory Disease Retrieval Sampling Schools Specimen Statistical Data Interpretation Time United States Update Validation Water Weight Woman air monitoring base civil society cohort community engagement community planning cypermethrin data access data integrity data management data sharing epidemiology study exposed human population improved mancozeb meetings member neurobehavioral neurobehavioral test neurodevelopment operation outreach program pesticide exposure programs respiratory respiratory health rural underserved tool underserved area underserved community urinary vector control web site young woman

项目摘要

Understanding the potential health effects of pesticides is difficult due to the episodic nature of exposure and the lack of individual’s knowledge regarding their personal exposure. The ISA Cohort study in Costa Rica is a community-based cohort of 350 mothers and their now 5-7 year old children living in Matina County, Costa Rica, a banana growing region for the country. These individuals are exposed to a variety of different chemicals as used in agriculture, mainly banana production, vector control, and pasture, including mancozeb, chlorpyrifos, pyrimethanil, thiabendazole, cypermethrin, and 2,4-D. Exposure to these and other pesticides, as well as manganese (a component of mancozeb), has been measured through biological and environmental monitoring of the cohort for the past six years. To date, investigators have been funded to assess growth and neurobehavioral outcomes associated with pre- and post-natal exposure to these pesticides, oxidative stress, and respiratory and allergic outcomes in mothers and children. The ISA cohort provides critical information to assess the potential human health effects of pesticides as these same pesticides are used in the US as well as Costa Rica. This proposal will strengthen the ISA cohort for the long-term by: 1) creating a more consistent outreach program to inform the cohort members as well as their communities, civil society organizations, governmental organizations and private sector about study findings on a regular basis; 2) updating participant medical history including neurobehavioral and respiratory outcomes and collecting biological samples every two years; 3) establishing more complete data documentation to allow for easier collaboration and data sharing; 4) providing long term specimen storage in Costa Rica; and 5) enhancing understanding of pesticide exposure in the cohort and community through aggregation of available exposure data for cohort participants, validation of urinary biomarkers with environmental sampling, air monitoring of pesticides at primary schools situated in the study area, and statistical approaches to manage the complex exposure data. This proposal focuses on a community-engaged model to enhance long term follow-up by collecting and report data relevant to the community on a routine basis.

由于偶发性质，了解农药的潜在健康影响很困难暴露和缺乏个人有关其个人接触的知识。 ISA队列哥斯达黎加的研究是一个社区的350个母亲及其现年5-7岁的孩子居住在该国的香蕉种植地区哥斯达黎加的马蒂娜县。这些人暴露于各种不同的化学物质中，主要是香蕉生产，矢量控制和牧场，包括Mancozeb，Chlorpyrifos，黄甲胺，Thiabendazole， Cypermethrin和2,4-D。暴露于这些和其他农药以及锰 Mancozeb的），已通过对队列的生物学和环境监测来衡量过去六年。迄今为止，已经资助了研究人员来评估生长和神经行为与这些农药，氧化应激和产后和产后暴露有关的结果，以及母亲和儿童的呼吸和过敏性结果。 ISA队列提供了关键信息以评估农药的潜在人类健康影响，因为这些相同的农药是在美国和哥斯达黎加使用。该建议将加强ISA队列长期：1）创建一个更一致的外展计划，以告知队列成员作为其社区，民间社会组织，政府组织和私营部门关于定期研究结果； 2）更新参与者的病史，包括神经行为和呼吸系统结局和每两年收集生物样品； 3）建立更完整的数据文档，以便更轻松地协作和数据共享； 4）在哥斯达黎加提供长期标本的存储； 5）增强对农药的理解通过汇总可用的曝光数据，在队列和社区中接触参与者，通过环境采样的尿液生物标志物的验证，空气监测位于研究区域的小学的农药，以及管理统计方法复杂的暴露数据。该提案着重于社区参与的模型，以增强长期通过常规收集和报告与社区相关的数据进行跟进。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

[Playful Learning: a tool for Environmental Education].

DOI：
10.15359/rca.56-1.10
发表时间：
2022-01
期刊：
Revista de ciencias ambientales = Tropical journal of environmental sciences
影响因子：
0
作者：
通讯作者：

Pyrimethanil and chlorpyrifos air concentrations and pregnant women's urinary metabolites in the Infants' Environmental Health Study (ISA), Costa Rica.

DOI：
10.1016/j.envint.2022.107328
发表时间：
2022-08
期刊：
ENVIRONMENT INTERNATIONAL
影响因子：
11.8
作者：
Giffin, Andrew;Hoppin, Jane A.;Cordoba, Leonel;Solano-Diaz, Karla;Ruepert, Clemens;Penaloza-Castaneda, Jorge;Lindh, Christian;Reich, Brian J.;de Joode, Berna van Wendel
通讯作者：
de Joode, Berna van Wendel

Pesticide risk perceptions among bystanders of aerial spraying on bananas in Costa Rica.