PFAS Exposure and Thyroid Related Health Outcomes in Communities along the Cape Fear River, NC

北卡罗来纳州开普菲尔河沿岸社区的 PFAS 暴露与甲状腺相关健康结果

• 批准号: 10337307
• 负责人: JANE HOPPIN
• 金额: $ 35.5万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10337307
• 关键词: Address; Adult; Affect; Age; Aging; Air; Antibodies; Back; Biological; Biomedical Research; Blood; Blood specimen; Body mass index; Characteristics; Chemicals; Child; Cholesterol; Clinic Visits; Clinical; Communication; Communities; Complex; Complex Mixtures; Data; Data Set; Development; Ensure; Environmental Health; Excretory function; Exposure to; Fright; Future; Gender; Health; Health Personnel; Heart Rate; Human; Individual; Life; Life Cycle Stages; Measures; Medical; Metabolic; Metabolism; Nafion; North Carolina; Obesity; Oral cavity; Outcome; Participant; Pattern; Persons; Plants; Poly-fluoroalkyl substances; Population; Population Heterogeneity; Pregnant Women; Privatization; Protocols documentation; Public Health; Questionnaires; Recording of previous events; Regulation; Reporting; Research Personnel; Research Project Grants; Rivers; Sample Size; Sampling; Sentinel; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Time; Toxicokinetics; United States; Universities; Urine; Variant; Water; Water Pollutants; Weight; Work; age group; cohort; community living; community partnership; community planning; community science; drinking water; insight; meetings; predictive modeling; prospective; racial diversity; reconstruction; recruit; superfund site; thyroid disruption; time use

ABSTRACT (Biomedical Research) Research Project 1 Project 1 is one of two Biomedical Research (BMR) Projects for the proposed “Center for Environmental and Health Effects of PFAS” being led by North Carolina State University (NC State). Per- and polyfluoroalkyl substances (PFAS) are common drinking water contaminants in NC and around the United States. Little is known about how long these chemicals stay in the body or what the human health impacts are. These chemicals have been detected in the drinking water of communities living along the Cape Fear River in NC. Working with three community groups along the Cape Fear River, we will evaluate PFAS exposure and thyroid health effects to people whose drinking water has been contaminated with PFAS. Disruption of thyroid hormones as well as metabolic outcomes such as obesity have been associated with PFAS in other populations. The three communities have exposure to different types of PFAS in their drinking water. Pittsboro, located on the Haw River in the upper region of the Cape Fear River basin, is exposed to historically used PFAS as a result of upstream use of firefighting foam, wastewater discharges, and land application of biosolids. The Fayetteville private well community is located near a fluorochemical plant that discharged PFAS to both air and water (Cape Fear River) since 1980; their wells are believed to be contaminated as a result of air transport. Wilmington, at the mouth of the Cape Fear River and downstream of the chemical plant, is exposed to both historically used PFAS (e.g., PFOA, PFOS) as well as a number of newly identified PFAS (e.g., GenX, Nafion byproduct 2). To study these diverse communities, we plan to recruit 1,200 individuals in the region (300 from Pittsboro, 200 from the Fayetteville private well community, and 700 from Wilmington) to evaluate how PFAS levels change over time, whether personal characteristics influence PFAS level as well as excretion from the body, and whether PFAS, either individually or as a group, influence thyroid outcomes. We plan to include individuals ages 6 and over who have lived in the region since July 2016. We will invite participants to clinic visits in Years 1 and 3 to collect blood and urine samples for PFAS and clinical analyses, administer questionnaires to obtain information on water use history, demographic characteristics, and medical and health outcomes. Working with our community partners, we will report back individual and community-level results on a regular basis. We will have Community Science Advisory Boards in each community to provide input to the study and ensure that the study investigators are well informed about community concerns. We anticipate finding PFAS mixtures in each community; we will use statistical approaches that allow us to evaluate individual PFAS while taking into account the complex mixture present. This study, with its complex mix of PFAS and racially diverse sample, will provide key insights to the human health implications of PFAS both in NC and around the world.

抽象的 （生物医学研究）研究项目1 项目1是拟议的“环境中心和 PFA的健康影响”由北卡罗来纳州立大学（NC州）领导。 物质（PFA）是北卡罗来纳州和美国各地的常见饮用水污染物。鲜为人知 这些化学物质停留在体内或人类健康的影响有多长时间。这些化学物质具有 我们在居住在北卡罗来纳州开普敦恐惧河沿岸的社区的饮用水中被发现。与三个合作 沿开普敦恐惧河的社区团体，我们将评估PFA的暴露和甲状腺健康影响 饮用水被PFA污染的人。甲状腺激素和 其他人群中的代谢结果（例如肥胖症）与PFA有关。三个 社区在其饮用水中暴露于不同类型的PFA。匹兹伯勒，位于鹰上 恐惧河盆地上部地区的河流因历史上使用的PFAS而导致 上游使用消防泡沫，废水排放和生物固体的土地施用。费耶特维尔 私人井社区位于荧光化学植物附近，该植物将PFA释放到空气和水中（Cape 自1980年以来，恐惧河）；据信他们的水井由于航空运输而受到污染。威尔明顿，在 Cape Cape Fear River和化学植物下游的嘴暴露在历史上使用 PFA（例如PFOA，PFO）以及许多新鉴定的PFA（例如Genx，Nafion副产品2）。到 研究这些潜水员社区，我们计划在该地区招募1,200个人（匹兹伯勒300人 Fayetteville私人井社区，Wilmington的700）评估PFAS水平如何变化 时间，个人特征是否影响PFA水平以及身体的排泄，以及是否影响 PFA是单独或作为一个组的PFA会影响甲状腺结果。我们计划包括6岁的个人和 自2016年7月以来一直居住在该地区的人。我们将邀请参与者参加1年和第3年的诊所访问 收集血液和尿液样品进行PFA和临床分析，管理问卷以获取信息 关于用水历史，人口特征以及医疗和健康结果。与我们一起工作 社区合作伙伴，我们将定期报告个人和社区级别的结果。我们将有 每个社区的社区科学咨询委员会为研究提供意见并确保研究 调查人员充分了解了社区的关注。我们预计每种都会发现PFAS混合物 社区;我们将使用统计方法，使我们能够在考虑时评估单个PFA 存在复杂的混合物。这项研究及其复杂的PFA和大致潜水样本的混合物将提供 PFA在NC和世界各地对人类健康影响的关键见解。