PFAS Exposure and Thyroid Related Health Outcomes in Communities along the Cape Fear River, NC

北卡罗来纳州开普菲尔河沿岸社区的 PFAS 暴露与甲状腺相关健康结果

基本信息

批准号：
10337307
负责人：
JANE HOPPIN
金额：
$ 35.5万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10337307
关键词：
Address Adult Affect Age Aging Air Antibodies Back Biological Biomedical Research Blood Blood specimen Body mass index Characteristics Chemicals Child Cholesterol Clinic Visits Clinical Communication Communities Complex Complex Mixtures Data Data Set Development Ensure Environmental Health Excretory function Exposure to Fright Future Gender Health Health Personnel Heart Rate Human Individual Life Life Cycle Stages Measures Medical Metabolic Metabolism Nafion North Carolina Obesity Oral cavity Outcome Participant Pattern Persons Plants Poly-fluoroalkyl substances Population Population Heterogeneity Pregnant Women Privatization Protocols documentation Public Health Questionnaires Recording of previous events Regulation Reporting Research Personnel Research Project Grants Rivers Sample Size Sampling Sentinel Thyroid Diseases Thyroid Function Tests Thyroid Gland Thyroid Hormones Time Toxicokinetics United States Universities Urine Variant Water Water Pollutants Weight Work age group cohort community living community partnership community planning community science drinking water insight meetings predictive modeling prospective racial diversity reconstruction recruit superfund site thyroid disruption time use

项目摘要

ABSTRACT (Biomedical Research) Research Project 1 Project 1 is one of two Biomedical Research (BMR) Projects for the proposed “Center for Environmental and Health Effects of PFAS” being led by North Carolina State University (NC State). Per- and polyfluoroalkyl substances (PFAS) are common drinking water contaminants in NC and around the United States. Little is known about how long these chemicals stay in the body or what the human health impacts are. These chemicals have been detected in the drinking water of communities living along the Cape Fear River in NC. Working with three community groups along the Cape Fear River, we will evaluate PFAS exposure and thyroid health effects to people whose drinking water has been contaminated with PFAS. Disruption of thyroid hormones as well as metabolic outcomes such as obesity have been associated with PFAS in other populations. The three communities have exposure to different types of PFAS in their drinking water. Pittsboro, located on the Haw River in the upper region of the Cape Fear River basin, is exposed to historically used PFAS as a result of upstream use of firefighting foam, wastewater discharges, and land application of biosolids. The Fayetteville private well community is located near a fluorochemical plant that discharged PFAS to both air and water (Cape Fear River) since 1980; their wells are believed to be contaminated as a result of air transport. Wilmington, at the mouth of the Cape Fear River and downstream of the chemical plant, is exposed to both historically used PFAS (e.g., PFOA, PFOS) as well as a number of newly identified PFAS (e.g., GenX, Nafion byproduct 2). To study these diverse communities, we plan to recruit 1,200 individuals in the region (300 from Pittsboro, 200 from the Fayetteville private well community, and 700 from Wilmington) to evaluate how PFAS levels change over time, whether personal characteristics influence PFAS level as well as excretion from the body, and whether PFAS, either individually or as a group, influence thyroid outcomes. We plan to include individuals ages 6 and over who have lived in the region since July 2016. We will invite participants to clinic visits in Years 1 and 3 to collect blood and urine samples for PFAS and clinical analyses, administer questionnaires to obtain information on water use history, demographic characteristics, and medical and health outcomes. Working with our community partners, we will report back individual and community-level results on a regular basis. We will have Community Science Advisory Boards in each community to provide input to the study and ensure that the study investigators are well informed about community concerns. We anticipate finding PFAS mixtures in each community; we will use statistical approaches that allow us to evaluate individual PFAS while taking into account the complex mixture present. This study, with its complex mix of PFAS and racially diverse sample, will provide key insights to the human health implications of PFAS both in NC and around the world.

抽象的（生物医学研究）研究项目1 项目 1 是拟议的“环境与环境中心”的两个生物医学研究 (BMR) 项目之一 PFAS 的健康影响》由北卡罗来纳州立大学（北卡罗来纳州）领导。物质 (PFAS) 是北卡罗来纳州和美国各地常见的饮用水污染物，但人们对此知之甚少。这些化学物质在体内停留的时间或这些化学物质对人类健康有什么影响。与三人合作，在北卡罗来纳州开普菲尔河沿岸社区的饮用水中检测到。开普菲尔河沿岸的社区团体，我们将评估 PFAS 暴露和甲状腺健康影响，以饮用水被 PFAS 污染的人甲状腺激素和甲状腺激素受到干扰。在其他人群中，肥胖等代谢结果与 PFAS 相关。位于 Haw 的皮茨伯勒社区的饮用水中含有不同类型的 PFAS。由于以下原因，开普菲尔河流域上游地区的河流暴露于历史上使用的 PFAS 中：消防泡沫的上游使用、废水排放和生物固体的土地应用。私人水井社区位于一家氟化工厂附近，该工厂向空气和水中排放 PFAS（开普敦） Fear River）自 1980 年以来，据信他们的水井因航空运输而受到污染。开普菲尔河河口和化工厂下游，暴露于历史上使用过的 PFAS（例如 PFOA、PFOS）以及一些新发现的 PFAS（例如 GenX、Nafion 副产品 2）。研究这些多样化的社区，我们计划在该地区招募 1,200 人（300 人来自皮茨伯勒，200 人来自费耶特维尔私人井社区和威尔明顿的 700 个）来评估 PFAS 水平如何变化时间、个人特征是否影响PFAS水平以及体内的排泄，以及是否 PFAS，无论是单独还是作为一个群体，都会影响甲状腺结果，我们计划将 6 岁至 6 岁的个体纳入其中。调查自 2016 年 7 月以来居住在该地区的人员。我们将邀请参与者在第一年和第三年到诊所就诊，收集血液和尿液样本进行 PFAS 和临床分析，进行问卷调查以获取信息与我们合作，了解用水历史、人口特征以及医疗和健康结果。社区合作伙伴，我们将定期报告个人和社区层面的结果。每个社区的社区科学咨询委员会为研究提供投入并确保研究调查人员充分了解社区关注的问题，我们预计会在每个区域中发现 PFAS 混合物。社区；我们将使用统计方法来评估个体 PFAS，同时考虑到本研究将提供 PFAS 和种族多样化样本的复杂组合。关于 PFAS 对北卡罗来纳州和世界各地人类健康影响的重要见解。