Data Management and Statistical Core

数据管理与统计核心

基本信息

批准号：
9756273
负责人：
HOWARD F. ANDREWS
金额：
$ 18.73万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9756273
关键词：
Academic Medical Centers Aging Alzheimer&apos s Disease Biometry Clinical Clinical Data Collaborations Consultations Data Data Analyses Data Base Management Data Coordinating Center Data Security Databases Development Doctor of Philosophy Doctor&apos s Degree Ensure Environment Epidemiologist Epidemiology Evaluation Faculty Funding Goals Individual Information Systems Knowledge Manuscripts Master&apos s Degree Medical Research Monitor Participant Play Policies Preparation Procedures Process Publications Research Research Design Research Personnel Research Project Grants Resources Role Running Schedule Secure Security Specialist Statistical Data Interpretation Structure System Techniques Time Training Training and Education Work arm central database cohort data management data resource data sharing data submission design experience follow-up meetings member normal aging psychobiology recruit relational database research clinical testing statistics

项目摘要

DATA MANAGEMENT AND STATISTICAL CORE SUMMARY The Database Management and Statistical Core (DMS) formalizes central data management and biostatistical resources and functions that have existed within the Clinical Core since the inception of the Columbia ADRC in 1989. The DMS Core, which was formally established five years ago, is composed of two component and well- coordinated arms, one for biostatistical/epidemiological and the other for data management functions. The Data Management Component will continue to manage a large, highly structured relational database currently containing all clinical evaluation and neuropathological examination data on a large cohort of over 3,800 subjects, including all NACC UDS data collected since the inception of the current UDS. In the proposed funding period the Database Management Component will continue to electronically submit initial and followup UDS packets in the format required by the National Alzheimer s Coordinating Center (NACC) in a timely manner, and will serve as a central resource for data, epidemiological and statistical resources to the projects described in this application, as well as to approved collaborations with external investigators and NACC-initiated research projects. The Statistics and Epidemiology Component will work closely with the investigators of each project to design and implement statistical analyses, and to assist in the preparation and review of manuscripts for publication. The Statistics and Epidemiology Component will also continue to be a resource for collaborative NACC projects and will participate in the design and analysis of collaborative ad hoc research efforts with external and internal investigators. Staff of both components of the DMS Core will continue to participate in weekly, scheduled meetings with leaders of the other cores and projects to review and discuss all data-related issues, including: 1) recruitment and followup ; 2) coordination of data flow between the clinical and neuropathological cores, and 4) the needs of the projects and collaborators for data, statistical planning and data analysis. The Database Management and Statistical Core plays an essential role in maintaining and organizing all Columbia ADRC data, coordinating evaluation and followup, and preparing and submitting data from Columbia for use in collaborative studies of the clinical and neuropathological aspects of Alzheimer s disease, through the National Alzheimer s Coordinating Center and other collaborative research initiatives.

数据管理和统计核心摘要数据库管理和统计核心 (DMS) 规范了中央数据管理和生物统计自哥伦比亚 ADRC 成立以来，临床核心中一直存在的资源和职能 1989年，五年前正式成立的DMS Core由两部分组成，协调的部门，一个负责生物统计/流行病学职能，另一个负责数据管理职能。数据管理组件目前将继续管理大型、高度结构化的关系数据库包含超过 3,800 名受试者的大型队列的所有临床评估和神经病理学检查数据，包括自当前 UDS 启动以来收集的所有 NACC UDS 数据。在拟议资助期内数据库管理组件将继续以电子方式提交初始和后续 UDS 数据包及时按照国家阿尔茨海默病协调中心 (NACC) 要求的格式，并将服务作为本文件所述项目的数据、流行病学和统计资源的核心资源申请，以及与外部研究人员和 NACC 发起的研究的批准合作项目。统计和流行病学部分将与每个项目的研究人员密切合作，设计并进行统计分析，并协助准备和审查出版稿件。统计和流行病学部分也将继续成为 NACC 合作项目的资源并将参与与外部和内部合作的临时研究工作的设计和分析调查人员。 DMS 核心两个组成部分的工作人员将继续参加每周定期的活动与其他核心和项目的领导者举行会议，审查和讨论所有与数据相关的问题，包括：1) 招募和跟进； 2) 协调临床和神经病理核心之间的数据流，以及 4) 项目和合作者对数据、统计规划和数据分析的需求。数据库管理和统计核心在维护和组织所有数据方面发挥着重要作用哥伦比亚 ADRC 数据，协调评估和后续行动，并准备和提交哥伦比亚数据用于阿尔茨海默病临床和神经病理学方面的合作研究，通过国家阿尔茨海默病协调中心和其他合作研究计划。