Patients Registry-Virtual Biorepository Core

患者登记处-虚拟生物样本库核心

• 批准号: 10183181
• 负责人: HOWARD F. ANDREWS
• 金额: $ 3.32万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10183181
• 关键词: Applications Grants; Barrett Esophagus; Beer; Bioinformatics; Biological Markers; Chemoprevention; Clinic; Collaborations; Data; Data Collection; Data Coordinating Center; Databases; Development; Doctor of Philosophy; Elements; Esophageal Adenocarcinoma; Excision; Funding; Future; Goals; Instruction; Leadership; Link; Malignant neoplasm of esophagus; Michigan; Morbidity - disease rate; Online Systems; Operative Surgical Procedures; Paper; Patients; Pennsylvania; Population; Publishing; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Services; Specimen; Structure; System; Time; Tissue Banks; Tissues; Translating; Universities; Update; Work; archive data; base; biobank; data archive; data exchange; data infrastructure; data management; data sharing; design; mortality; patient registry; risk stratification; virtual; web site

PROJECT SUMMARY The Patient Registry and Biorepository has been designed to provide an optimal infrastructure for data collection and archiving, data sharing, and biospecimen resource distribution in order to facilitate the successful completion of the proposed Research projects as well as future Pilot and Cross-BETRNet Projects. The database underlying the Columbia-UPenn-Mayo Patient Registry and Biorepository has been designed to integrate seamlessly with the central system maintained at the BETRNet Coordinating Center and to maximize ease of collaboration with other BETRNet Research Centers. The system has been designed to efficiently transfer database to BETRNet Coordinating Center and to disseminate results among multiple venues. The tissue repository is based on a large, long-standing tissue bank of surgical resections for esophageal cancer. This Columbia-Mayo-Penn Patient Registry and Biorepository will serve as a unique resource for the three projects that will be carried out during the proposed funding period, as well as for future projects related to esophageal adenocarcinoma. The system has been designed specifically to achieve the following goals: facilitating research related to the development of BE and its progression to EAC; translating these findings to the patient-level with regards to biomarkers for risk stratification and chemoprevention; and ultimately reducing the morbidity and mortality of EAC at a population level. The existing project website, which includes a link allowing direct access to the BETRNet Coordinating Center, will be updated on a regular basis to include postings of research results and provide access to published papers. A web-based Data Request form will also be added to faciitate the delivery of data to investigators.

项目概要 患者登记和生物样本库旨在为数据提供最佳基础设施 收集和归档、数据共享和生物样本资源分配，以方便 成功完成拟议的研究项目以及未来的试点和跨 BETRNet 项目。 哥伦比亚大学-宾夕法尼亚大学-梅奥分校患者登记和生物样本库的数据库旨在 与 BETRNet 协调中心维护的中央系统无缝集成，并最大限度地提高 与其他 BETRNet 研究中心轻松合作。该系统的设计目的是有效地 将数据库传输至 BETRNet 协调中心并在多个场所之间传播结果。这 组织库基于一个大型、长期存在的食管癌手术切除组织库。 哥伦比亚-梅奥-宾夕法尼亚州患者登记处和生物样本库将作为这三个机构的独特资源 将在拟议供资期内开展的项目以及与以下相关的未来项目 食管腺癌。该系统经过专门设计，旨在实现以下目标： 促进与 BE 发展及其向 EAC 进展相关的研究；将这些发现转化为 患者层面的风险分层和化学预防生物标志物；并最终减少 EAC 在人口水平上的发病率和死亡率。现有项目网站，其中包含一个链接 允许直接访问 BETRNet 协调中心，将定期更新以包括 发布研究成果并提供已发表论文的访问权限。基于网络的数据请求表将 还可以添加以方便向调查人员提供数据。