Alliance for Regenerative Rehabilitation Research & Training (AR3T)

再生康复研究联盟

• 批准号: 9145751
• 负责人: MICHAEL L. BONINGER
• 金额: $ 107.12万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-17 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9145751
• 关键词: Accountability; Activities of Daily Living; Acute; Age; Aging; Animal Model; Applications Grants; Basic Science; Biological Markers; Biological Models; Chronic; Clinical; Collaborations; Communities; Congenital Abnormality; Country; Data Analyses; Development; Disabled Persons; Discipline; Disease; Documentation; E-learning; Effectiveness; Ensure; Evaluation; Fostering; Foundations; Funding; Future; Goals; Health; Home environment; In Vitro; Incubators; Individual; Injury; Institutes; Institution; Intervention; Investigation; Knowledge; Laboratories; Life; Measurement; Mechanical Stimulation; Mechanics; Methodology; Methods; Monitor; Muscle satellite cell; Organ; Pathology; Performance; Physical Function; Physical Medicine; Physical activity; Physiological; Prevention; Process; Protocols documentation; Recommendation; Regenerative Medicine; Rehabilitation Research; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Training; Resources; Safety; Science; Scientist; Series; Signal Transduction; Skeletal Muscle; Specialist; Stem cells; Stimulus; Structure; Technology; Tissue Engineering; Tissues; Training; Translating; Trauma; Work; bioluminescence imaging; career; cell behavior; design; falls; frontier; improved; in vivo; innovation; interest; massive open online courses; mode of exercise; multidisciplinary; novel; operation; programs; regenerative; regenerative therapy; rehabilitation science; rehabilitation technology; repaired; response; restoration; sabbatical; stem cell therapy; success; symposium; therapy design; tissue regeneration; tissue repair; tool; webinar

 DESCRIPTION (provided by applicant): The advancement of regenerative medicine principles and technologies holds great potential to drive progress in the prevention and treatment of individuals with a host of pathologies resulting from injury, disease or aging. The long-term goal of regenerative medicine is to promote the repair, replacement, or regeneration of tissues. Likewise, rehabilitation seeks to harness the body's innate regenerative potential in order to maximize function. Both fields hold great potential to drive progress in the treatment of a host of acute and chronic pathologies. We propose that these two fields are inextricably intertwined; an intersection of disciplines known as Regenerative Rehabilitation. To fully realize the tremendous potential of Regenerative Rehabilitation, we must promote the interaction of basic scientists with rehabilitation specialists. We must also train rehabilitation clinicians who can help oversee the quality, safety, and validity of these innovative Regenerative Rehabilitation technologies. The overarching goal of the Alliance for Regenerative Rehabilitation Research & Training (AR3T) is to establish a national network that will expand scientific knowledge, expertise and methodologies across the domains of regenerative medicine and rehabilitation. AR3T will provide didactic training that exposes rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies in the field of regenerative medicine (Specific Aim 1). AR3T will drive the science underlying Regenerative Rehabilitation by: cultivating collaborative opportunities among rehabilitation researchers and internationally renowned investigators in the field of regenerative medicine (Specific Aim 2); launching a pilot funding program to support novel lines of Regenerative Rehabilitation investigations (Specific Aim 3); developing and validating technologies to elucidate the stem cell response to extrinsic mechanical signals (Specific Aim 4). Careful monitoring and evaluation of the effectiveness of our program, as outlined in Specific Aim 5, will ensure that these aims achieve the greatest success possible. These five aims have been organized to parallel each of the P2C grant proposal components.

 描述（由适用提供）：再生医学原理和技术的进步具有巨大的潜力，可以推动预防和治疗因受伤，疾病或衰老而导致多种病理的个体的进步。再生医学的长期目标是促进组织的修复，置换或再生。同样，康复旨在利用人体的先天再生潜力，以最大程度地发挥功能。这两个领域都有巨大的潜力推动一系列宿主的进步 急性和慢性病理。我们建议这两个领域是密不可分的。被称为再生康复的学科的交集。为了充分实现再生康复的巨大潜力，我们必须促进基础科学家与康复专家的相互作用。我们还必须培训可以帮助监督这些创新性再生康复技术的质量，安全性和有效性的康复临床医生。再生康复研究与培训联盟（AR3T）的总体目标是建立一个国家网络，该网络将扩大跨再生医学和康复领域的科学知识，专业知识和方法。 AR3T将提供教学培训，该培训使康复研究人员在再生医学领域进行尖端的研究和最先进的技术（特定目标1）。 AR3T会 推动科学的基础再生康复康复方法：在康复研究人员和国际著名的研究人员中培养合作机会（特定目的2）；启动一项试点资金计划，以支持新的再生康复调查线（特定目标3）；开发和验证技术以阐明干细胞对外部机械信号的反应（特定目标4）。仔细监视和评估我们计划的有效性，如特定目标5所述，将确保这些目标取得最大的成功。已经组织了这五个目标，以使每个P2C赠款提案组成部分平行。