Alliance for Regenerative Rehabilitation Research & Training (AR3T)

再生康复研究联盟

基本信息

批准号：
9763645
负责人：
Fabrisia Ambrosio
金额：
$ 105.02万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-17 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763645
关键词：
3-Dimensional Accountability Activities of Daily Living Acute Age Aging Animal Model Applications Grants Basic Science Biological Markers Biological Models Chronic Clinical Collaborations Communities Congenital Abnormality Country Data Analyses Development Disabled Persons Discipline Disease Documentation E-learning Effectiveness Ensure Evaluation Fostering Foundations Funding Future Goals Home environment In Vitro Incubators Individual Injury Institutes Institution International Intervention Investigation Knowledge Laboratories Measurement Mechanical Stimulation Mechanics Methodology Methods Monitor Muscle satellite cell Organ Pathology Performance Physical Function Physical Medicine Physical activity Physiological Prevention Process Protocols documentation Recommendation Regenerative Medicine Rehabilitation Research Rehabilitation therapy Research Research Design Research Personnel Research Training Resources Safety Science Scientist Series Signal Transduction Skeletal Muscle Specialist Stem cells Stimulus Structure Technology Tissue Engineering Tissues Training Translating Trauma Treatment Efficacy Work career cell behavior design falls frontier improved in vivo in vivo bioluminescence imaging innovation interest investigator training massive open online courses mode of exercise multidisciplinary novel operation programs public health relevance regenerative regenerative therapy rehabilitation science rehabilitation technology repaired response restoration sabbatical stem cell therapy success symposium therapy design tissue regeneration tissue repair tool webinar

项目摘要

DESCRIPTION (provided by applicant): The advancement of regenerative medicine principles and technologies holds great potential to drive progress in the prevention and treatment of individuals with a host of pathologies resulting from injury, disease or aging. The long-term goal of regenerative medicine is to promote the repair, replacement, or regeneration of tissues. Likewise, rehabilitation seeks to harness the body's innate regenerative potential in order to maximize function. Both fields hold great potential to drive progress in the treatment of a host of acute and chronic pathologies. We propose that these two fields are inextricably intertwined; an intersection of disciplines known as Regenerative Rehabilitation. To fully realize the tremendous potential of Regenerative Rehabilitation, we must promote the interaction of basic scientists with rehabilitation specialists. We must also train rehabilitation clinicians who can help oversee the quality, safety, and validity of these innovative Regenerative Rehabilitation technologies. The overarching goal of the Alliance for Regenerative Rehabilitation Research & Training (AR3T) is to establish a national network that will expand scientific knowledge, expertise and methodologies across the domains of regenerative medicine and rehabilitation. AR3T will provide didactic training that exposes rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies in the field of regenerative medicine (Specific Aim 1). AR3T will drive the science underlying Regenerative Rehabilitation by: cultivating collaborative opportunities among rehabilitation researchers and internationally renowned investigators in the field of regenerative medicine (Specific Aim 2); launching a pilot funding program to support novel lines of Regenerative Rehabilitation investigations (Specific Aim 3); developing and validating technologies to elucidate the stem cell response to extrinsic mechanical signals (Specific Aim 4). Careful monitoring and evaluation of the effectiveness of our program, as outlined in Specific Aim 5, will ensure that these aims achieve the greatest success possible. These five aims have been organized to parallel each of the P2C grant proposal components.

描述（由申请人提供）：再生医学原理和技术的进步具有巨大的潜力，可以推动因损伤、疾病或衰老而导致的多种病症的个体的预防和治疗方面取得进展。再生医学的长期目标是。同样，康复旨在利用人体固有的再生潜力，以最大限度地发挥功能，这两个领域都具有推动许多疾病治疗进展的巨大潜力。我们认为这两个领域是密不可分的；为了充分发挥再生康复的巨大潜力，我们还必须促进基础科学家与康复专家的互动。再生康复研究与培训联盟 (AR3T) 的总体目标是建立一个可帮助监督这些创新再生康复技术的质量、安全性和有效性的康复机构。 AR3T 将扩展再生医学和康复领域的科学知识、专业知识和方法的国家网络，将提供教学培训，让康复研究人员接触再生医学领域的前沿研究和最先进的技术。具体目标1).AR3T将通过以下方式推动再生康复的科学发展：培养再生医学领域康复研究人员和国际知名专家之间的合作机会（具体目标 2）；启动试点资助计划，支持再生康复研究的新方向（具体目标 3）；验证技术以阐明干细胞对外在机械信号的反应（具体目标 4），如具体目标 5 中所述，仔细监测和评估我们计划的有效性。将确保这些目标取得最大成功。这五个目标的组织与 P2C 拨款提案的每个组成部分并行。