Alliance for Regenerative Rehabilitation Research & Training 2.0 (AR3T)

再生康复研究联盟

• 批准号: 10830114
• 负责人: Fabrisia Ambrosio
• 金额: $ 108.39万
• 依托单位: SPAULDING REHABILITATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10830114
• 关键词: Accountability; Activities of Daily Living; Age; Attention; Awareness; Basic Science; Biocompatible Materials; Clinical; Collaborations; Communities; Congenital Abnormality; Country; Data Analyses; Development; Disabled Persons; Discipline; Disease; Documentation; Education; Effectiveness; Eligibility Determination; Ensure; Evaluation; Feedback; Fostering; Foundations; Funding; Future; Goals; In Vitro; Incubators; Individual; Injury; Institution; Intervention; Investigation; Journals; Knowledge; Laboratories; Learning; Machine Learning; Marketing; Measurement; Mentors; Methodology; Methods; Mission; Monitor; Natural regeneration; Organ; Performance; Physical Function; Pre-Clinical Model; Preparation; Process; Quality Control; Reader; Regenerative Medicine; Rehabilitation therapy; Research; Research Design; Research Personnel; Resources; Science; Scientist; Series; Signal Transduction; Specialist; Stimulus; Structure; Systems Analysis; Technology; Text; Time; Tissues; Training; Trauma; Treatment Efficacy; Update; career; effectiveness evaluation; falls; functional restoration; gait examination; healing; improved; injured; innovation; interest; mechanical stimulus; multidisciplinary; new technology; novel; novel strategies; pre-clinical; programs; regeneration potential; regenerative; regenerative rehabilitation; regenerative therapy; rehabilitation research; rehabilitation science; repaired; response; sabbatical; social media; success; symposium; technological innovation; technology validation; therapy design; tissue regeneration; webinar

OVERALL: ABSTRACT The scope of regenerative medicine encompasses the repair, regeneration, and replacement of defective, injured, and diseased tissues and organs. The success of regenerative therapies is dependent, at least in part, on a favorable microenvironment in which the regenerative processes occur. Technological innovations and a deepened mechanistic understanding of how these microenvironmental signals influence tissue regeneration has drawn attention to the critical importance of the clinical field with foundations in the application of physical, thermal, and electrical stimuli to promote functional restoration—rehabilitation. We propose that the fields of regenerative medicine and rehabilitative science are inextricably intertwined, an intersection of disciplines that we and others have termed Regenerative Rehabilitation. To realize the full potential of Regenerative Rehabilitation, there is a need for formalized mechanisms that promote the interaction of basic scientists with rehabilitation specialists. During the initial funding cycle, the Alliance for Regenerative Rehabilitation Research & Training (AR3T) built a national network of investigators and programs that has helped to expand scientific knowledge, expertise and methodologies across the domains of regenerative medicine and rehabilitation. This proposal seeks funding for AR3T 2.0, in which we will build on successes achieved and lessons learned over the initial period of support with the goal of being even more responsive to the needs of the greater community. Six specific aims define a framework upon which we will achieve our goals. AR3T will provide education and drive the science underlying Regenerative Rehabilitation by: 1) Providing didactic programs that expose rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies in the field of regenerative medicine (Didactic Aim); 2) Cultivating collaborative opportunities between renowned investigators in the fields of regenerative medicine and rehabilitation (Collaborations Aim); 3) Coordinating a pilot funding program to support novel lines of Regenerative Rehabilitation research (Pilot Funding Aim); 4) Developing and validating technologies to advance the measurement and use of the regenerative rehabilitation programs (Technology Aim); 5) Promoting our center’s expertise to a broad community of trainees, investigators, and clinicians (Promotion Aim); 6) Carefully monitoring and evaluating the effectiveness of our program will ensure that we are successful in achieving our goals (Quality Control Aim). Administrative note: In the preparation of this proposal, we made every effort to present a comprehensive and detailed plan for achieving our goals while minimizing redundancy. Therefore, in multiple places, we refer the reader to specific components of the application, rather than repeating text. We appreciate the time and effort the reviewers devote to the evaluation of the proposals. Sincerely, Fabrisia, Tom and Mike

总体：摘要 再生医学的范围包括修复、再生和替换有缺陷的、 受伤和患病的组织和器官再生疗法的成功至少部分取决于 再生过程发生的有利微环境。 加深了对这些微环境信号如何影响组织再生的机制理解 提请人们注意临床领域的至关重要性，并为物理应用奠定基础， 热和电刺激促进功能恢复——康复。 再生医学和康复科学密不可分，是两个学科的交叉点 我们和其他人将其称为“再生康复”，以实现再生的全部潜力。 康复方面，需要建立正式的机制来促进基础科学家与 在最初的资助周期中，再生康复研究联盟。 与培训 (AR3T) 建立了一个全国性的研究人员和项目网络，帮助扩大科学 再生医学和康复领域的知识、专业知识和方法。 该提案为 AR3T 2.0 寻求资金，我们将借鉴过去取得的成功和吸取的经验教训 初期支持的目标是更好地满足更大社区的需求 六。 具体目标定义了一个框架，AR3T 将在此基础上提供教育和推动。 再生康复的科学依据： 1) 提供教学计划，揭示 康复研究人员在康复领域进行前沿研究和最先进的技术 再生医学（教学目标）；2）培养知名人士之间的合作机会 再生医学和康复领域的研究人员（合作目标）3）协调 支持再生康复研究新方向的试点资助计划（试点资助目标 4）； 开发和验证技术以推进再生康复的测量和使用 计划（技术目标）；5）向广泛的学员社区推广我们中心的专业知识， 6) 仔细监控和评估我们的有效性 该计划将确保我们成功实现我们的目标（质量控制目标）。 行政说明：在准备本提案的过程中，我们尽一切努力提出全面且全面的建议。 实现我们的目标同时最大限度地减少冗余的详细计划因此，在多个地方，我们参考了 我们感谢读者阅读应用程序的特定组件，而不是重复文本。 评审员致力于对提案的评估。 此致，法布里西亚、汤姆和迈克

项目成果

A Non-Invasive Method for Generating the Cyclic Loading-Induced Intra-Articular Cartilage Lesion Model of the Rat Knee.

• DOI: 10.3791/62660
• 发表时间: 2021-07-05
• 期刊: Journal of visualized experiments : JoVE
• 作者: Ji X;Nakahata A;Zhao Z;Kuroki H;Aoyama T;Ito A
• 通讯作者: Ito A

Epigenetic silencing directs expression heterogeneity of stably integrated multi-transcript unit genetic circuits.

• DOI: 10.1038/s41598-021-81975-1
• 发表时间: 2021-01-28
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zimak J;Wagoner ZW;Nelson N;Waechtler B;Schlosser H;Kopecky M;Wu J;Zhao W
• 通讯作者: Zhao W

Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats.

• DOI: 10.1038/s41598-017-11260-7
• 发表时间: 2017-09-07
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Dalise S;Cavalli L;Ghuman H;Wahlberg B;Gerwig M;Chisari C;Ambrosio F;Modo M
• 通讯作者: Modo M

Stimulation strategies for electrical and magnetic modulation of cells and tissues.

• DOI: 10.1186/s13619-023-00165-8
• 发表时间: 2023-07-01
• 期刊: Cell regeneration (London, England)

Primary Hip Arthroscopy in Patients With Acetabular Dysplasia: A Systematic Review of Published Clinical Outcomes at Minimum 5-Year Follow-up.

髋臼发育不良患者的初次髋关节镜检查：对已发表的至少 5 年随访临床结果的系统评价。

• DOI: 10.1177/03635465231197177
• 发表时间: 2024
• 期刊: The American journal of sports medicine
• 作者: Boos,AlexanderM;Nagelli,ChristopherV;Okoroha,KelechiR;Sierra,RafaelJ;Krych,AaronJ;Hevesi,Mario
• 通讯作者: Hevesi,Mario