Molecularly Engineered Biomaterials for Minimally Invasive Dental Treatment

用于微创牙科治疗的分子工程生物材料

• 批准号: 8593065
• 负责人: YONGREN Benjamin PENG
• 金额: $ 18.21万
• 依托单位: XL SCI-TECH, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8593065
• 关键词: Air; Air Pressure; Aluminum Oxide; Area; Biochemical; Biochemistry; Biocompatible Materials; Biomechanics; Ceramics; Chemistry; Composite Resins; Data Analyses; Defect; Dental; Dental Enamel; Dental Materials; Dental caries; Dentin; Engineering; Evaluation; Excision; Gel; Generations; Genetic; Glass; Goals; Hardness; In Vitro; Measures; Microspheres; Minerals; Molecular Structure; Mono-S; Orthodontic; Performance; Phase; Plant Resins; Play; Porosity; Powder dose form; Preparation; Procedures; Process; Property; Protein Structure Initiative; Research; Research Personnel; Route; School Dentistry; Techniques; Technology; Temperature; Testing; Therapeutic; Time; Tissues; Tooth structure; Toxic effect; bone; clinically relevant; cost; crosslink; cytotoxicity; improved; in vivo; melting; meter; minimally invasive; nano; pressure; public health relevance; repaired; response; sound; success; tissue repair; trend

DESCRIPTION (provided by applicant): Molecularly Engineered Biomaterials for Minimally Invasive Dental Treatment Molecularly-engineered biomaterials are an ideal candidate for minimally invasive dental preparations, caries removal, and other dental treatments, including cleaning in perigingival zone and other general cleaning and whitening. Through the control of molecular structure, the biochemical and biomechanical properties can be tailored and optimized. The investigators propose to use the well- established biochemistry to create a class of new dental materials useful for minimally-invasive dental preparation and useful as tissue repair agents potentially loaded with therapeutics. Processing chemistry is to be integrated with advanced nano/micro-fabrication technology to enhance the success rate of the Phase I feasibility. Preliminary toxicity assessment will also be conducted on selected materials. Phase II will focus on the biomechanical performance in vivo, especially regarding dental preparation and defect removal.

描述（由申请人提供）：用于微创牙科治疗的分子工程生物材料分子工程生物材料是微创牙科预备、龋齿清除和其他牙科治疗（包括龈周区域清洁和其他一般清洁和美白）的理想候选材料。通过分子结构的控制，可以定制和优化生化和生物力学特性。研究人员建议利用成熟的生物化学来创造一类新的牙科材料，可用于微创牙科预备，并可用作可能负载治疗剂的组织修复剂。加工化学将与先进的纳米/微米制造技术相结合，以提高第一阶段可行性的成功率。还将对选定的材料进行初步毒性评估。第二阶段将重点关注体内生物力学性能，特别是牙齿预备和缺损去除方面。