EMA and Lab Assessment of Nicotine Dependence among Dual ENDS Users

EMA 和实验室对双 ENDS 用户尼古丁依赖性的评估

• 批准号: 8757366
• 负责人: Jennifer Lynn Pearson
• 金额: $ 16.66万
• 依托单位: TRUTH INITIATIVE FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8757366
• 关键词: Active Learning; Address; Affect; Award; Behavior; Behavioral; Behavioral Research; Characteristics; Cigarette; Cigarette Smoker; Clinical; Commit; Complement; Data; Data Collection; Devices; Distal; Electronics; Evaluation; Future; Goals; Human; Institutes; Intention; K-Series Research Career Programs; Knowledge; Laboratories; Laboratory Research; Link; Measures; Mentors; Mentorship; Methodology; Methods; Modeling; Nicotine; Nicotine Dependence; Outcome; Participant; Pattern; Perception; Pharyngeal structure; Plasma; Play; Procedures; Psychological reinforcement; Publishing; Randomized; Recontacts; Regulation; Research; Research Methodology; Research Personnel; Research Proposals; Role; Science; Smoker; Surveys; Time; Tobacco; Tobacco use; Training; Visit; Woman; Work; Writing; addiction; behavioral pharmacology; career; cigarette smoking; craving; design; experience; human PEN-2 protein; innovation; novel; public health relevance; public health research; satisfaction; skills; smoking cessation; social; tobacco abuse; tobacco control

DESCRIPTION (provided by applicant): My principal career goal is to become an expert in how tobacco product characteristics influence tobacco use behavior using novel laboratory, survey, and qualitative methodologies. My goal for this K01 Career Development Award in Tobacco Control Regulatory Research is to obtain the training to research how product characteristics, namely tobacco product abuse liability and appeal, affect tobacco use behavior. To gain this knowledge and requisite research skills, I propose mentorship, didactic training, and experiential learning through research focused on the behavioral pharmacology of addiction and human laboratory research methods. The proposed research will contribute to FDA tobacco regulation by identifying the initial differential effects of ciga-like and pen-like ECIGs on ECIG experimentation and subsequent tobacco cigarette smoking behavior. To our knowledge, this will be the first study to combine clinical laboratory and real-world data collection of ECIG experimentation in smokers, as well as the first to compare explicitly the effect of the two major ECIG device types. Results will directly address the issues of ECIG abuse liability, nicotine exposure, and reinforcing efficacy. This research will also begin the work necessary to understand the effect of ECIG availability on subsequent tobacco cigarette smoking quit attempts. This study will be my first experience with primary data collection using human lab methods and my application of the effect of tobacco abuse liability and appeal on tobacco use behavior. Additionally, this research will compliment and expand upon my concurrent social and behavioral research on the impact of norms and harm perceptions on ECIG experimentation and combusted tobacco use. With outstanding mentors (Drs. Ray Niaura and Tom Eissenberg) who are committed to my training and believe in the importance of my proposed research, as well as strong institutional support from the Schroeder Institute, I am poised to develop into an independent and highly productive research investigator. This Career Development Award would enable me to devote 75% of my time to didactic training in behavioral pharmacology, develop expertise training in clinical laboratory methods to complement my skills in survey research, and write an R01 research proposals to launch my career as an independent investigator in tobacco regulatory science.

描述（由申请人提供）：我的主要职业目标是成为烟草产品特征如何使用新型实验室，调查和定性方法来影响烟草行为的专家。我在烟草控制监管研究中获得的K01职业发展奖的目标是获得培训，以研究产品特征，即烟草产品滥用责任和吸引力，影响烟草的使用行为。为了获得这些知识和必要的研究技能，我通过研究专注于成瘾和人类实验室研究方法的研究指导，教学培训和体验式学习。拟议的研究将通过确定类似CIGA和笔状的ECIG对ECIG实验以及随后的烟草吸烟行为的初始差异作用来促进FDA烟草调节。据我们所知，这将是第一项结合吸烟者中ECIG实验的临床实验室和现实数据收集的研究，也是第一个明确比较两种主要ECIG设备类型的效果的研究。结果将直接解决ECIG滥用责任，尼古丁暴露和增强功效的问题。这项研究还将开始必要的工作，以了解ECIG的可用性对随后的烟草烟烟戒烟的尝试。这项研究将是我使用人类实验室方法收集主要数据的第一次经验，以及我对烟草滥用责任的影响以及对烟草使用行为的上诉。此外，这项研究将补充和扩展我的社会和行为研究对规范和危害对ECIG实验和燃烧烟草使用的影响的影响。 有了杰出的导师（Ray Niaura和Tom Eissenberg博士），他们致力于我的培训，并相信我拟议的研究的重要性，以及Schroeder Institute的强大机构支持，我有望发展成为一名独立且高产的研究研究员。该职业发展奖将使我能够将75％的时间用于行为药理学的教学培训，在临床实验室方法中开发专业知识培训，以补充我的调查研究技能，并撰写R01研究建议，以启动我作为托巴科科监管科学的独立调查员的职业。