Genetic and Neural Complexity in Psychiatry

精神病学中的遗传和神经复杂性

• 批准号: 8269786
• 负责人: MARIA KARAYIORGOU
• 金额: $ 4.99万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8269786
• 关键词: Address; Animals; Brain Diseases; Cell model; Communication; Development; Developmental Cell Biology; Discipline; Early treatment; Future; Generations; Genetic; Goals; Mental disorders; Mutation; Neurobiology; Neurosciences; Patients; Prevention strategy; Psychiatry; Research; Series; Shapes; Technology; Time; Translations; abstracting; design; gene function; meetings; mouse model; nonhuman primate; novel strategies; psychogenetics; relating to nervous system; symposium

Abstract Recent advances in the field of psychiatric genetics have brought about excitement and urgency to envision and design intelligently the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment. The primary goal of the meeting on the "Genetic and Neural Complexity in Psychiatry" is to facilitate a discussion on the future of research in Psychiatry as it is shaped by the recent advances in genetics and newly emerging concepts and approaches in neuroscience. This meeting will bring together experts and open a dialogue between geneticists and neuroscientists allowing direct translation and speedy application of recent findings. The first planned meeting in the proposed series of 3 bi-annual meetings, will focus on deep sequencing approaches, which will allow discovery of rare, highly penetrant mutations, as well as on approaches designed to understand their impact on gene function, including the generation of mouse models. It will also address emerging reprogramming technologies that allow development of cellular models from patients carrying specific rare mutations as well as the pros and cons of studying additional animal species with particular emphasis on non-human primates. Finally, it will highlight and discuss novel approaches to decipher circuitry and communication in the disease brain.

抽象的 精神遗传学领域的最新进展带来了兴奋和紧迫感，需要明智地设想和设计下一步，以便为精神疾病的神经生物学提供信息，并制定预防、早期干预或治疗的策略。关于“精神病学中的遗传和神经复杂性”会议的主要目标是促进对精神病学研究未来的讨论，因为它是由遗传学的最新进展和神经科学中新兴的概念和方法塑造的。这次会议将汇集专家，并在遗传学家和神经科学家之间展开对话，以便直接翻译和快速应用最新的发现。拟议的每两年一次的 3 次会议系列中的第一次计划会议将重点讨论深度测序方法，该方法将允许发现罕见的、高渗透性突变，以及旨在了解其对基因功能影响的方法，包括生成鼠标模型。它还将讨论新兴的重编程技术，这些技术允许从携带特定罕见突变的患者开发细胞模型，以及研究其他动物物种（特别是非人类灵长类动物）的利弊。最后，它将重点介绍并讨论破译患病大脑中的电路和通信的新方法。