Ectopic adiposity in black men with high type 2 diabetes risk

患有 2 型糖尿病高风险的黑人男性异位肥胖

• 批准号: 8735936
• 负责人: IVA MILJKOVIC
• 金额: $ 47.51万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735936
• 关键词: Abdomen; Abdominal Muscles; Address; Adipocytes; Adipose tissue; Affect; African American; Aging; Archives; Biological; Biological Markers; Choristoma; Confounding Factors (Epidemiology); Data; Development; Economic Burden; Elderly; Epidemiology; Etiology; Evolution; Fatty Acids; Fatty acid glycerol esters; Funding; Funding Mechanisms; Glucose; Glucose Intolerance; Health; High Prevalence; Homeostasis; Image; Individual; Infiltration; Inflammation; Inflammation Mediators; Insulin; Insulin Resistance; Interleukin-6; Learning; Leptin; Liver; Low Prevalence; Measures; Metabolic; Monocyte Chemoattractant Protein-1; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Non obese; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pericardial body location; Phenotype; Physiological; Pilot Projects; Population; Prevalence; Research; Research Personnel; Resources; Risk Factors; Role; Scanning; Serum; Skeletal Muscle; Specimen; Testing; Time; Tissues; Tobago; Universities; Visceral; X-Ray Computed Tomography; adiponectin; age related; aged; attenuation; base; blood glucose regulation; cohort; cost efficient; diabetes risk; epidemiologic data; fasting glucose; fatty acid oxidation; fatty acid transport; high risk; high risk men; human FABP4 protein; innovation; insight; macrophage; men; novel; older men; population based; programs; public health relevance; racial and ethnic disparities; subcutaneous

DESCRIPTION (provided by applicant): Obesity and type 2 diabetes (T2D) disproportionately affect black individuals. Generalized obesity and other established risk factors do not explain the racial disparity in T2D, and this is particularly evident among men. Emerging evidence indicates that fat accumulation in non-adipose tissues (referred to as ectopic adiposity) may be associated with T2D, independent of general obesity. Compared to white men, both obese and lean black men have less visceral and liver adiposity, while in contrast, they paradoxically have more skeletal muscle adiposity. Skeletal muscle is crucial for maintaining glucose homeostasis, and thus, skeletal muscle adiposity may be the key adipose tissue depot contributing to increased T2D risk in blacks. However, much remains to be learned about the epidemiology of skeletal muscle adiposity, particularly among high-risk black populations. Through the K01 (DK083029) and R03 (DK092348) funded pilot studies for new investigators, the applicant has begun to investigate the epidemiology of skeletal muscle adiposity and other ectopic adipose tissue depots in a well-characterized, large cohort of black men from the Tobago Health Study. This cohort offers a unique opportunity to study a black population with low levels of total adiposity, and low prevalence of other potential confounding variables, but with a high prevalence of T2D, especially among non- obese men. We are proposing to continue and expand upon our preliminary research on ectopic adiposity in this cohort. We will take advantage of our unique resource of archived computed tomography (CT) scan image files from over 1500 black men, aged 40 years and above, to analyze skeletal muscle adiposity changes over an average of nearly 7 years, and characterize the natural history of skeletal muscle adiposity changes with aging in black men, and the temporal relationship of these changes with glucose and insulin homeostasis. We will also use archived biological specimens to measure physiologic markers of potential importance for skeletal muscle adiposity, and test several compelling hypotheses about the etiology and consequences of skeletal muscle adiposity. In addition, we will obtain new CT measures of visceral, liver, abdominal muscle and pericardial adiposity, and will test for an association of abdominal skeletal muscle adiposity with measures of glucose and insulin homeostasis, and determine if these associations are independent of liver, visceral and pericardial adiposity. The proposed study will greatly advance our understanding of ectopic adiposity and its role in T2D among high risk black men.

描述（由申请人提供）：肥胖和2型糖尿病（T2D）不成比例地影响黑人个体。广义肥胖和其他已建立的危险因素不能解释 T2D的种族差异，这在男性中尤为明显。新兴的证据表明，非脂肪组织中的脂肪积累（称为异位肥胖）可能与T2D有关，与一般肥胖无关。与白人相比，肥胖的黑人男性的内在和肝肥胖较少，而相反，他们自相矛盾的是，骨骼肌肥胖更具。骨骼肌对于维持葡萄糖稳态至关重要，因此，骨骼肌肥胖可能是脂肪组织仓库的关键，导致黑人T2D风险增加。然而，关于骨骼肌肥胖的流行病学还有很多待了解，尤其是在高风险的黑人人群中。通过K01（DK083029）和R03（DK092348）为新研究者提供的试点研究，申请人已开始研究骨骼肌肥胖和其他副本脂肪组织库的流行病学，在一项良好的，大型的黑人男性中，来自Tobago Goago Health研究的大型黑人男性。该队列提供了一个独特的机会，可以研究其总肥胖水平较低，其他潜在混杂变量较低的黑人人群，但T2D的患病率很高，尤其是在非肥胖男性中。我们建议继续并扩展我们对该队列异位肥胖的初步研究。我们将利用我们从1500多名40岁及以上的1500多名黑人男性的归档计算机断层扫描（CT）扫描图像文件的独特资源，分析骨骼肌肉肥胖平均近7年的变化，并表征了黑人男性与胶状和胰岛素的临时关系的骨骼肌肉肥胖变化的自然历史。我们还将使用存档的生物标本来测量对骨骼肌肥胖潜在重要性的生理标志物，并检验一些关于骨骼肌肥胖的病因和后果的令人信服的假设。此外，我们将获得内脏，肝脏，腹部肌肉和心包肥胖的新CT测量，并将测试腹部骨骼肌肉肥胖与葡萄糖和胰岛素稳态测量的关联，并确定这些关联是否独立于肝脏，内脏和周心脂肪。拟议的研究将大大提高我们对异位肥胖的理解及其在高风险黑人中的T2D中的作用。