High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

高强度间歇训练（HIIT）可减少老年退伍军人的虚弱并增强其恢复能力

• 批准号: 10539160
• 负责人: Bruce R. Troen
• 金额: --
• 依托单位: KANSAS CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10539160
• 关键词: Activities of Daily Living; Address; Adult; Affect; Age; Age Years; Aging; Award; Bioenergetics; Biological; Biological Markers; Blood; Blood Cells; C-reactive protein; Clinical Trials; Cognition; Cognitive; Complex; Control Groups; Elderly; Enrollment; Equilibrium; Exercise; Exhibits; Female; Genus Hippocampus; Goals; Health; Heart Rate; Home; Homeostasis; Hospitalization; Human; Impairment; Individual; Inflammation; Inflammatory; Interleukin-10; Interleukin-6; Interval training; Learning; Measures; Methods; MicroRNAs; Mission; Mitochondria; Molecular; Motor; Mus; Muscle; Participant; Physical Function; Physical Performance; Physical assessment; Physiological; Predisposition; Prevalence; Quality of life; Randomized; Randomized, Controlled Trials; Recovery; Regimen; Response to stimulus physiology; Series; Serum; Stress; Stretching; Testing; Therapeutic; Training Programs; United States; Veterans; Walking; adverse outcome; age group; age related; attentional control; biological systems; cardiorespiratory fitness; cognitive function; cognitive performance; cognitive recovery; cognitive testing; comorbidity; disability; evidence base; executive function; falls; feasibility trial; frailty; health care service utilization; healthspan; high risk; human old age (65+); improved; inflammatory marker; innovation; male; metabolic profile; miRNA expression profiling; mitochondrial metabolism; monocyte; mortality; muscle form; next generation sequencing; novel marker; novel strategies; peripheral blood; prevent; promote resilience; resilience; response; stressor; success

Impact of Home-Based High Intensity Interval Training on Resilience in Older Veterans More than 30% of U.S. Veterans 65 years or older are frail, which is three-times higher than in non-Veterans in the same age group. Frailty is defined as an increased susceptibility to stressors resulting from age-related impairments in adaptive biological systems, leading to higher risk of adverse outcomes including falls, disability, hospitalization, and mortality. Further, frailty prevalence increases with age, affecting 50% of all adults 85 and over. Resilience, which is defined as the capacity to recover from stress-induced disruptions to homeostasis, is critical to successful aging because it precedes frailty and presents an opportunity to intervene on early health deficits, thus preventing aging-related decline in health, function, and quality of life. Evidence-based therapies that enhance resilience in older adults are limited and the complex biological and physiological mechanisms underlying resilience are not yet fully understood. Consequently, Veterans seeking to boost their ability to recover from late-life stressors and prevent frailty have few proven options. Our overarching aim is to characterize the complex factors contributing to resilience and develop novel strategies that enhance resilience to boost healthspan in older adults. Towards this end, our previous VA RR&D SPiRE Award allowed us to demonstrate the feasibility of 12-weeks of high intensity interval training (HIIT) among older Veterans. We successfully enrolled and retained older male and female Veterans and safely conducted individually tailored HIIT that improved cardiorespiratory fitness, lower-body endurance, cognition, and quality of life. The purpose of the proposed larger trial is to build upon our previous successes and develop and implement practical HIIT regimens to reduce frailty and enhance resilience in older Veterans. We will conduct a randomized controlled trial to ascertain the therapeutic benefits of 12-weeks of center- and home-based HIIT on recovery and resilience among Veterans 60 years or older. We have identified a series of biomarkers of resilience and are also seeking to examine key biological drivers of recovery at the molecular level. Our proposed study will not only identify feasible methods to measure resilience in older Veterans but will also assess the benefits of home-based HIIT on physical and cognitive performance, frailty, resilience, and healthspan.

家庭高强度间歇训练对老年退伍军人恢复能力的影响 超过 30% 的 65 岁及以上美国退伍军人身体虚弱，这一数字是美国的三倍 同一年龄段的非退伍军人。虚弱被定义为对压力源的敏感性增加，导致 适应性生物系统中与年龄相关的损伤，导致不良后果的风险更高 包括跌倒、残疾、住院和死亡。此外，虚弱患病率随着年龄的增长而增加， 影响 50% 的 85 岁及以上成年人。弹性，定义为从灾难中恢复的能力 压力引起的体内平衡破坏对于成功衰老至关重要，因为它先于虚弱和衰老 提供了一个干预早期健康缺陷的机会，从而防止与衰老相关的健康状况下降 健康、功能和生活质量。增强老年人恢复能力的循证疗法是 复原力背后的复杂生物和生理机制是有限的，尚未得到充分研究 明白了。因此，退伍军人寻求提高从晚年压力中恢复的能力， 预防虚弱几乎没有经过验证的选择。我们的首要目标是描述复杂因素的特征 促进复原力并制定新的战略，增强复原力，从而延长健康寿命 老年人。为此，我们之前获得的 VA RR&D SPiRE 奖让我们能够展示 对老年退伍军人进行 12 周高强度间歇训练 (HIIT) 的可行性。我们成功地 招募并留住老年男性和女性退伍军人，并安全地进行单独定制的 HIIT 改善心肺健康、下半身耐力、认知和生活质量。目的 拟议的更大规模试验的目的是在我们以前的成功基础上发展和实施实际的 HIIT 疗法可减少老年退伍军人的虚弱状况并增强其恢复能力。我们将进行随机 对照试验以确定 12 周中心和家庭 HIIT 的治疗效果 60 岁或以上退伍军人的恢复和复原力。我们已经确定了一系列生物标志物 复原力，并正在寻求在分子水平上研究恢复的关键生物驱动因素。我们的 拟议的研究不仅将确定衡量老年退伍军人复原力的可行方法，而且还将 还评估家庭 HIIT 对身体和认知表现、虚弱、恢复力、 和健康寿命。