Epidemiology of Obesity, Diabetes, and Hypertension in African Caribbeans
非洲加勒比地区肥胖、糖尿病和高血压的流行病学
基本信息
- 批准号:10245074
- 负责人:
- 金额:$ 62.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdipose tissueAffectAfricanAfrican AmericanAfrican CaribbeanAgeAgingAlcohol consumptionAmericanArchivesBehavioralBlood PressureBlood VesselsBody CompositionBody fatBody mass indexBody measure procedureCardiometabolic DiseaseCardiovascular DiseasesCaribbean regionCaucasiansCollectionCoronary Artery Risk Development in Young Adults StudyCost of IllnessDNADataDiabetes MellitusDual-Energy X-Ray AbsorptiometryEpidemicEpidemiologyEthnic OriginFamilyFatty acid glycerol estersFishesFoundationsFundingFutureGrowthHealthHigh PrevalenceHypertensionImageInfrastructureIntakeKnowledgeLife StyleLongitudinal StudiesLow PrevalenceMeasuresMedicalMenarcheMenopauseMetabolismNon-Insulin-Dependent Diabetes MellitusNutritionalObesityOrganOverweightPhenotypePopulationPopulation ResearchPrevalenceProceduresProcessProtocols documentationRNARaceReadingRecording of previous eventsReportingResearchResourcesRiskRisk FactorsSamplingSkeletal MuscleSleepSmokingSpecimenThinnessTimeTobagoUltrasonographyVisceralWeightWest IndiesWomanbasebiobankcardiometabolismcardiovascular healthcirculating biomarkerscohortcostcost effectiveepidemiology studyethnic disparityexperiencefruits and vegetableshigh riskinsightlifestyle factorsmenmicrobialnovelparitypopulation basedprotective factorsracial and ethnic disparitiesrecruitreproductivesedentary lifestylesex
项目摘要
PROJECT SUMMARY/ABSTRACT
Obesity is a very strong risk factor for type 2 diabetes (T2D) and hypertension, which disproportionately affect
African ancestry populations. The Caribbean region in particular is experiencing an enormous epidemic of
cardio-metabolic disease, with obesity, T2D, and hypertension being considerably higher in African Caribbeans
compared to Caribbeans of other race/ethnicities. Despite the current and projected growth in obesity, T2D and
hypertension among African Caribbeans, the mechanisms underlying racial/ethnic disparities in these
devastating and costly conditions remain largely unknown. T2D and hypertension are driven in part by obesity
and body fat distribution, especially fat around and within non-adipose tissue organs (known as ectopic
adiposity). Our recent discovery that ectopic skeletal muscle adiposity contributes to incident T2D and
hypertension in African Caribbean men supports the hypothesis that ectopic adiposity may be a key risk factor
contributing to increased risk of T2D and hypertension in African Caribbean populations. However, in contrast
to African Caribbean men, very little is known about the importance of body fat distribution and ectopic
adiposity for T2D, hypertension, and resultant cardiovascular disease in African Caribbean women. Our
preliminary data underscores the need to extend research to include African Caribbean women to unravel the
sex-specific and obesity-related mechanisms for T2D, hypertension and cardiovascular disease (CVD) and to
discover novel factors related to these major conditions in African ancestry populations. Over the past 20 years
we have been studying a unique population-based cohort of African Caribbean men from Tobago. We now
propose to expand our research on obesity, T2D, hypertension, and CVD among African Caribbean men to
include African Caribbean women in Tobago. We will collect data on lifestyle and medical factors,
anthropometrics, DXA and CT body composition measures, carotid ultrasound measures of subclinical
cardiovascular disease, and create a specimen biobank for future proposals using our existing infrastructure
and well-established procedures. In these newly recruited women, we propose to: 1) determine the overall, and
age- and BMI- specific prevalence of T2D and hypertension in African Caribbean women in Tobago, and
compare the prevalence with our existing data in men; 2) identify traditional and novel lifestyle, cultural,
behavioral, reproductive, nutritional, and medical-related risk factors for T2D and hypertension among African
Caribbean women, and 3) evaluate the association of body fat distribution and ectopic adiposity in African
Caribbean women with prevalent T2D and hypertension, and compare these associations with those
previously observed in African Caribbean men. In addition to accomplishing these aims, the collection and
archiving of vital specimens and measures (e.g., fecal samples for microbial distribution; DNA and RNA
extraction for omics based approaches), and reading of archived vascular images for subclinical CVD will
create the foundation for subsequent, focused funding proposals. Finally, combined with our existing data in
men, our study will provide a rich resource for the long-term study of cardio-metabolic health among African
Caribbeans and enable future comparisons to similarly phenotyped cohorts of African Americans.
项目摘要/摘要
肥胖是2型糖尿病(T2D)和高血压的非常强大的危险因素,对
非洲血统人群。尤其是加勒比地区正在经历
肥胖,T2D和高血压在非洲加勒比海地区的心脏代谢疾病较高
与其他种族/族裔的加勒比人相比。尽管肥胖症目前和预计的增长,但T2D和
非洲加勒比海地区的高血压,这些机制的种族/种族差异是这些机制
毁灭性和昂贵的条件在很大程度上仍然未知。 T2D和高血压部分由肥胖驱动
和体内脂肪分布,尤其是周围和非脂肪组织器官内的脂肪(称为异位
肥胖)。我们最近发现的,异位骨骼肌肥胖有助于事件T2D和
非洲加勒比海男性的高血压支持了异位肥胖可能是关键危险因素的假设
在非洲加勒比海人口中增加了T2D和高血压的风险增加。但是,相反
对于非洲加勒比海人,对体内脂肪分布和异位的重要性知之甚少
非洲加勒比妇女的T2D,高血压和由此导致的心血管疾病的肥胖。我们的
初步数据强调了扩展研究的必要性,以包括非洲加勒比妇女以揭示
T2D,高血压和心血管疾病(CVD)的性别特异性和肥胖相关机制以及
发现与非洲血统人群中这些主要条件有关的新因素。在过去的20年中
我们一直在研究来自多巴哥的非洲加勒比海人群。我们现在
建议扩大我们对非洲加勒比海男性肥胖,T2D,高血压和CVD的研究
在多巴哥包括非洲加勒比妇女。我们将收集有关生活方式和医疗因素的数据,
人类学,DXA和CT身体组成测量,颈动脉超声测量亚临床
心血管疾病,并创建一个标本生物库,用于使用我们现有基础设施的未来建议
和完善的程序。在这些新招募的妇女中,我们建议:1)确定整体,并
T2D的年龄和BMI-特定于Tobago的T2D和高血压的患病率,以及
将患病率与我们在男性中的现有数据进行比较; 2)确定传统和新颖的生活方式,文化,
非洲的行为,生殖,营养和与医疗相关的危险因素和高血压
加勒比妇女和3)评估非洲人体脂肪分布和异位肥胖的关联
患有T2D和高血压的加勒比妇女,并将这些关联与这些关联与
以前在非洲加勒比海人中观察到。除了实现这些目标,集合和
归档重要标本和措施(例如,微生物分布的粪便样品; DNA和RNA
提取基于OMIC的方法),并阅读亚临床CVD的存档血管图像
为后续的,重点的资金提案创造基础。最后,结合我们现有数据
男士,我们的研究将为非洲的心脏代谢健康的长期研究提供丰富的资源
加勒比人并使未来的比较与非洲裔美国人的类似表型队列进行比较。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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IVA MILJKOVIC其他文献
IVA MILJKOVIC的其他文献
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{{ truncateString('IVA MILJKOVIC', 18)}}的其他基金
The Study of Muscle and Physical Performance in African Caribbeans.
非洲加勒比海地区肌肉和身体表现的研究。
- 批准号:
10598636 - 财政年份:2022
- 资助金额:
$ 62.76万 - 项目类别:
Myosteatosis, Cognition and Blood Biomarkers of Alzheimer's Disease in Persons of African Ancestry
非洲血统人群阿尔茨海默病的肌肉脂肪变性、认知和血液生物标志物
- 批准号:
10447294 - 财政年份:2022
- 资助金额:
$ 62.76万 - 项目类别:
Epidemiology of Obesity, Diabetes, and Hypertension in African Caribbeans
非洲加勒比地区肥胖、糖尿病和高血压的流行病学
- 批准号:
9752328 - 财政年份:2018
- 资助金额:
$ 62.76万 - 项目类别:
Ectopic adiposity in black men with high type 2 diabetes risk
患有 2 型糖尿病高风险的黑人男性异位肥胖
- 批准号:
8418160 - 财政年份:2013
- 资助金额:
$ 62.76万 - 项目类别:
Ectopic adiposity in black men with high type 2 diabetes risk
患有 2 型糖尿病高风险的黑人男性异位肥胖
- 批准号:
8892172 - 财政年份:2013
- 资助金额:
$ 62.76万 - 项目类别:
Ectopic adiposity in black men with high type 2 diabetes risk
患有 2 型糖尿病高风险的黑人男性异位肥胖
- 批准号:
8735936 - 财政年份:2013
- 资助金额:
$ 62.76万 - 项目类别:
Association of Type 2 Diabetes with Liver and Muscle Adiposity in Black Men
黑人男性 2 型糖尿病与肝脏和肌肉肥胖的关系
- 批准号:
8165517 - 财政年份:2011
- 资助金额:
$ 62.76万 - 项目类别:
Association of Type 2 Diabetes with Liver and Muscle Adiposity in Black Men
黑人男性 2 型糖尿病与肝脏和肌肉肥胖的关系
- 批准号:
8328607 - 财政年份:2011
- 资助金额:
$ 62.76万 - 项目类别:
Epidemiology and Genetics of Skeletal Muscle Composition
骨骼肌组成的流行病学和遗传学
- 批准号:
8132812 - 财政年份:2008
- 资助金额:
$ 62.76万 - 项目类别:
Epidemiology and Genetics of Skeletal Muscle Composition
骨骼肌组成的流行病学和遗传学
- 批准号:
7571202 - 财政年份:2008
- 资助金额:
$ 62.76万 - 项目类别:
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