Epidemiology and Genetics of Skeletal Muscle Composition

骨骼肌组成的流行病学和遗传学

基本信息

批准号：
8132812
负责人：
IVA MILJKOVIC
金额：
$ 13.26万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8132812
关键词：
Adipose tissue Admixture African Age Aging Alcohols Area Biology Body fat Candidate Disease Gene Caribbean region Caucasians Caucasoid Race Cohort Studies Confounding Factors (Epidemiology)DNA Resequencing Data Diabetes Mellitus Disease Elderly Epidemiology Equipment and supply inventories Evaluation Family Fatty acid glycerol esters Genes Genetic Genetic Polymorphism Genetic Variation Genotype Glucose Goals Health Human Hyperglycemia Image Individual Infiltration Insulin Insulin Resistance Intramuscular Learning Longitudinal Studies Low Prevalence Measures Metabolic Diseases Metabolism Muscle Obesity Pattern Pharmacotherapy Population Recruitment Activity Sampling Scanning Sequence Analysis Skeletal Muscle Smoking Testing Time Tobago Variant Woman X-Ray Computed Tomography aged cohort density ethnic difference experience follow-up genetic epidemiology genetic variant human FABP4 protein men novel skills subcutaneous

Adipose tissue Admixture African Age Aging Alcohols Area Biology Body fat Candidate Disease Gene Caribbean region Caucasians Caucasoid Race Cohort Studies Confounding Factors (Epidemiology)DNA Resequencing Data Diabetes Mellitus Disease Elderly Epidemiology Equipment and supply inventories Evaluation Family Fatty acid glycerol esters Genes Genetic Genetic Polymorphism Genetic Variation Genotype Glucose Goals Health Human Hyperglycemia Image Individual Infiltration Insulin Insulin Resistance Intramuscular Learning Longitudinal Studies Low Prevalence Measures Metabolic Diseases Metabolism Muscle Obesity Pattern Pharmacotherapy Population Recruitment Activity Sampling Scanning Sequence Analysis Skeletal Muscle Smoking Testing Time Tobago Variant Woman X-Ray Computed Tomography aged cohort density ethnic difference experience follow-up genetic epidemiology genetic variant human FABP4 protein men novel skills subcutaneous

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项目摘要

DESCRIPTION (provided by applicant): Skeletal muscle fat accumulation, independent of overall body fat, may contribute to hyperglycemia and insulin resistance, disorders that are highly prevalent in populations of African origin. A few studies conducted mainly in women or in small samples, also suggest that individuals of African ancestry may have increased skeletal muscle fat compared to Caucasians, independent of overall body fat. However, much remains to be learned about the epidemiology of skeletal muscle composition and its relationship to metabolic disorders, particularly in populations of African ancestry. The goal of the proposed application is to characterize the epidemiology of ectopic skeletal muscle fat. Components of skeletal muscle composition including muscle cross-sectional area, total, subcutaneous, and intermuscular adipose tissue areas, and skeletal muscle density will be measured from existing quantitative computed tomography (pQCT) scans in 2200 men of Caucasian and African descent. The specific aims are to: (1) determine if there are ethnic differences in the distribution of skeletal muscle fat; (2) evaluate if genetic variations in the fatty-acid binding protein 4 gene contribute to skeletal muscle composition in men of African and Caucasian ancestry; and (3) to test the hypothesis that skeletal muscle fat increases with advancing age. The candidate's goals are to: (1) acquire new skills in quantitative computed tomography imaging of skeletal muscle composition; (2) become proficient in high-throughput genotyping and DMA sequence analysis; (3) obtain field experience in conducting longitudinal studies of skeletal muscle composition. PUBLIC HEALTH RELEVANCE: The accomplishment of the proposed aims will greatly enhance our understanding of the epidemiology and genetics of ectopic fat infiltration in skeletal muscle and its relationship to diabetes.

描述（由申请人提供）：骨骼肌脂肪的积累，与整体体内脂肪无关，可能导致高血糖和胰岛素抵抗，在非洲起源人群中极为普遍。与高加索人相比，与总体脂肪无关的高加索人相比，一些主要在女性或小样本中进行的研究也表明，非洲血统的个体可能增加了骨骼肌脂肪。但是，关于骨骼肌组成的流行病学及其与代谢疾病的关系，特别是在非洲血统的种群中，还有许多待了解的知识。提出的应用的目的是表征异位骨骼肌脂肪的流行病学。骨骼肌组成的成分，包括肌肉横截面区域，总，皮下和肌间脂肪组织区域以及骨骼肌密度，将从现有的定量计算机断层扫描（PQCT）扫描中测量，该扫描中的2200名男性和非洲血统。具体目的是：（1）确定骨骼肌脂肪的分布是否存在种族差异；（2）评估脂肪酸结合蛋白4基因的遗传变异是否有助于非洲和高加索血统男性的骨骼肌组成；（3）测试骨骼肌脂肪随着年龄的增长而增加的假设。候选人的目标是：（1）在骨骼肌组成的定量计算机断层扫描成像中获得新技能；（2）精通高通量基因分型和DMA序列分析；（3）获得进行骨骼肌组成纵向研究的现场经验。公共卫生相关性：拟议目的的完成将大大增强我们对骨骼肌异位脂肪浸润的流行病学和遗传学的理解及其与糖尿病的关系。