PILOT AND EXPLORATORY STUDIES CORE

试点和探索性研究核心

基本信息

批准号：
8459410
负责人：
Marco Pahor
金额：
$ 19.81万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8459410
关键词：
Address Age Aging American Animals Area Atherosclerosis Basic Science Biomechanics Biometry Cardiac Case-Control Studies Chronic Clinical Clinical Research Collaborations Coughing Data Data Analyses Data Collection Diabetes Mellitus Diet Dietary Intervention Disease Doctor of Philosophy Early Diagnosis Elderly Elderly woman Ensure Environment Epigenetic Process Extramural Activities Fatty acid glycerol esters Florida Fostering Foundations Funding Future Goals Grant Human Impairment Infection Insulin Resistance Intervention Investigation Lead Leptin resistance Link Lung Lung diseases Mentors Modeling Monitor Muscle Obesity Performance Phase Physical Function Physical assessment Physiological Physiology Pilot Projects Predisposition Preparation Prevention Preventive Intervention Pulmonology Quality of life Recurrence Research Research Infrastructure Research Personnel Respiratory Muscles Risk Rodent Role Safety Source Stroke Talents Testing Time Translating Translations United States National Institutes of Health Universities Work age related career clinical practice data management design disability dosage experience innovation insight instrumentation interdisciplinary approach interest muscle strength mycobacterial neuromuscular novel novel strategies offspring pre-clinical prevent research study respiratory sarcopenia

项目摘要

The goal of the OAIC Pilot/Exploratory Studies Core is to support the planning of future independently funded studies with a high potential to advance our understanding of the underlying mechanisms of and preventive interventions for sarcopenia and physical disability in older Americans. This goal is achieved by soliciting and selecting promising innovative pilot and exploratory studies that address the overall OAIC research theme of 'sarcopenia and prevention of disability'. The core fosters pilot and exploratory studies by ensuring the availability of optimal infrastructure, environment, funding, expertise, and instrumentation. The core leaders monitor study progress, assist in the analysis and interpretation of results, and provide guidance in translating pilot data into high quality and original research study proposals that successfully compete for independent extramural funding. The provision of funds for pilot and exploratory studies supports Junior Scholars in their efforts to develop research careers in aging. The core also allows accomplished investigators in the area of aging to gather data which extend and broaden their focus. Finally, the core serves as a vehicle to encourage and facilitate experienced investigators traditionally working in other research fields, such as biomechanics, physiology or pulmonology, to expand their research focus on aging. This broadens the pool of talent contributing to advances in understanding and preventing sarcopenia and disability. We are highly successful in translating findings from our pilot and exploratory studies from the previous funding cycle. Of a total of 19 directly supported or jointly supported pilot studies, 13 have garnered additional funding through NIH, VA and foundation sources; and the remaining 6 are still in the data collection phase, or have grants pending and in preparation. One exploratory and two pilot studies, are proposed in this application. The resultant portfolio of pilot/exploratory study proposals provides a broad variety of interdisciplinary approaches in addressing the OAIC research theme.

OAIC 试点/探索性研究核心的目标是支持未来独立资助研究的规划，这些研究很有可能促进我们对美国老年人肌少症和身体残疾的基本机制和预防干预措施的理解。这一目标是通过征集和选择有前途的创新试点和探索性研究来实现的，这些研究涉及 OAIC“肌肉减少症和残疾预防”的总体研究主题。该核心通过确保最佳基础设施、环境、资金、专业知识和仪器的可用性来促进试点和探索性研究。核心领导者监控研究进展，协助分析和解释结果，并为将试点数据转化为高质量的原创研究提供指导研究成功竞争独立校外资金的提案。为试点和探索性研究提供资金支持初级学者努力发展老龄化研究事业。该核心还允许老龄化领域的资深研究人员收集数据，从而扩展和拓宽他们的研究范围。重点。最后，该核心作为一种工具，鼓励和促进传统上在其他研究领域（例如生物力学、生理学或肺病学）工作的经验丰富的研究人员扩大他们对衰老的研究重点。这扩大了人才库，有助于增进对肌肉减少症和残疾的理解和预防。我们非常成功地转化了上一个资助周期的试点和探索性研究的结果。在总共 19 项直接支持或联合支持的试点研究中，13 项通过 NIH、VA 和基金会获得了额外资金；其余6个仍在数据中收集阶段，或有待决和准备中的赠款。本申请提出了一项探索性研究和两项试点研究。由此产生的试点/探索性研究提案组合为解决 OAIC 研究主题提供了广泛的跨学科方法。