Claude D. Pepper Older Americans Independence Center (OAIC)

克劳德·D·佩珀美国老年人独立中心 (OAIC)

• 批准号: 7678855
• 负责人: Marco Pahor
• 金额: $ 14.65万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678855
• 关键词: Acute; Address; Age; Aging; American; Animals; Apoptosis; Area; Arts; Basic Science; Behavior Therapy; Behavioral; Behavioral Sciences; Biological; Biological Markers; Biological Preservation; Biomechanics; Biostatistics Core; Caloric Restriction; Chronic; Clinical; Clinical Research; Condition; Coronary; Coronary heart disease; Degenerative polyarthritis; Development; Diabetes Mellitus; Discipline; Disease; Elderly; Energy Metabolism; Environment; Epidemiology; Equilibrium; Event; Exercise; Florida; Funding; Genetic; Genomics; Geriatrics; Goals; Heart; Heart failure; Hip Fractures; Impaired cognition; Inflammation; Institutes; Intervention; Investigation; Knowledge; Lead; Leadership; Lung diseases; Mediating; Mission; Mitochondria; Modeling; Molecular Biology; Muscle; Muscle function; Obesity; Organ; Oxidative Stress; Pathway interactions; Persons; Physical Function; Pilot Projects; Prevention; Process; Public Health; Recovery; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Risk Factors; Role; Services; Severities; Skeletal Muscle; Skeletal system; Stroke; Testing; Training; Translating; Translational Research; Universities; age related; career; data management; disability; disabling disease; experience; improved; interdisciplinary approach; loss of function; multidisciplinary; muscle strength; novel; novel strategies; post stroke; pre-clinical; pre-clinical research; preclinical study; prevent; programs; psychosocial; research and development; sarcopenia; skills

The mission of the University of Florida Older Americans Independence Center (OAIC) is to assess the risk factors of physical disability in older adults, develop and test effective prevention and rehabilitation therapies, and train new investigators in research on aging and disability, while developing their leadership qualities. Our strategy is to attract studies and investigators from diverse behavioral, clinical, and basic science disciplines towards research on aging that is focused on a common research theme, and this, in turn, will allow us to accomplish our mission. The theme, "sarcopenia, prevention and rehabilitation of disability", will be pursued using an interdisciplinary approach that traverses the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, and epidemiology. This research theme addresses the general goal of the OAIC program, namely, to increase scientific knowledge that will lead to better ways to maintain or restore independence of older persons. Our research objectives are to (1) assess, using translational research (between basic and clinical disciplines) multiple factors such as biological, genetic, co-morbid, psychosocial, and behavioral that contribute to sarcopenia, physical function decline, and progression to disability and (2) develop and reliably test in clinical and preclinical studies interventions that target sarcopenia, in order to prevent, delay or recover the age-related declines in physical function and the progression to disability. To address these objectives the proposed OAIC will include the following integrated cores, which will support investigators, Junior Scholars, infrastructure, and services: the Leadership and Administrative Core, the Research Career Development Core, the Pilot / Exploratory Studies Core, the Clinical Research Core, the Preclinical Research Core, the Biostatistics and Data Management Core, the Recruitment Core, and the Genomics and Biomarkers Core. During the first year we will train nine Junior Scholars and support seven external studies, three research development projects, two pilot studies, one exploratory study and nine small pilot/exploratory studies. A major strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects and investigators that address one common research theme to be explored through the whole spectrum of biomedical investigation.

佛罗里达大学老年人独立中心（OAIC）的使命是评估风险 老年人身体残疾的因素，开发和检验有效的预防和康复疗法， 并在发展领导质量的同时培训有关衰老和残疾研究的新调查人员。 我们的策略是吸引来自不同行为，临床和基础科学的研究和研究人员 迈向研究衰老的学科，该研究专注于共同的研究主题，这反过来将 允许我们完成任务。主题是“肌肉减少症，预防和康复残疾”，将会 使用跨学科的方法来追求，该方法遍历整个生物医学研究的范围 包括分子生物学，动物研究，临床研究，行为科学和流行病学。这 研究主题解决了OAIC计划的一般目标，即增加科学知识 这将导致更好的方法来维持或恢复老年人的独立性。我们的研究目标 （1）使用转化研究（基本学科和临床学科之间）评估多个因素 作为生物学，遗传，合并，社会心理和行为，有助于肌肉减少症 功能下降，以及对残疾的发展，（2）在临床和临床前的发展和可靠测试 为了防止，延迟或恢复与年龄相关的下降的研究干预措施 身体机能和残疾的发展。为了解决这些目标，拟议的OAIC将会 包括以下综合核心，该核心将支持研究人员，初级学者，基础设施和 服务：领导力和行政核心，研究职业发展核心，飞行员 / 探索性研究核心，临床研究核心，临床前研究核心，生物统计学和 数据管理核心，招聘核心以及基因组学和生物标志物核心。在第一个 一年，我们将培训九名初级学者，并支持七项外部研究，三项研究开发 项目，两项试点研究，一项探索性研究和九个小型试点/探索性研究。主要优势 拟议的OAIC是跨学科核心，项目和调查人员的一致行动， 解决一个通过生物医学范围探索的一个常见研究主题 调查。