Claude D. Pepper Older Americans Independence Center (OAIC)

克劳德·D·佩珀美国老年人独立中心 (OAIC)

• 批准号: 7429687
• 负责人: Marco Pahor
• 金额: $ 67.84万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7429687
• 关键词: Address; Aging; American; Animals; Basic Science; Behavioral; Behavioral Sciences; Biological; Biological Markers; Biostatistics Core; Clinical; Clinical Research; Development; Discipline; Elderly; Epidemiology; Florida; Genetic; Genomics; Goals; Intervention; Investigation; Knowledge; Lead; Leadership; Mission; Molecular Biology; Physical Function; Pilot Projects; Prevention; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Risk Factors; Services; Testing; Training; Translational Research; Universities; age related; career; data management; disability; interdisciplinary approach; pre-clinical research; preclinical study; prevent; programs; psychosocial; research and development; sarcopenia

DESCRIPTION (provided by applicant): The mission of the University of Florida Older Americans Independence Center (OAIC) is to assess the risk factors of physical disability in older adults, develop and test effective prevention and rehabilitation therapies, and train new investigators in research on aging and disability, while developing their leadership qualities. Our strategy is to attract studies and investigators from diverse behavioral, clinical, and basic science disciplines towards research on aging that is focused on a common research theme, and this, in turn, will allow us to accomplish our mission. The theme, "sarcopenia, prevention and rehabilitation of disability", will be pursued using an interdisciplinary approach that traverses the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, and epidemiology. This research theme addresses the general goal of the OAIC program, namely, to increase scientific knowledge that will lead to better ways to maintain or restore independence of older persons. Our research objectives are to (1) assess, using translational research (between basic and clinical disciplines) multiple factors such as biological, genetic, co-morbid, psychosocial, and behavioral that contribute to sarcopenia, physical function decline, and progression to disability and (2) develop and reliably test in clinical and preclinical studies interventions that target sarcopenia, in order to prevent, delay or recover the age-related declines in physical function and the progression to disability. To address these objectives the proposed OAIC will include the following integrated cores, which will support investigators, Junior Scholars, infrastructure, and services: the Leadership and Administrative Core, the Research Career Development Core, the Pilot / Exploratory Studies Core, the Clinical Research Core, the Preclinical Research Core, the Biostatistics and Data Management Core, the Recruitment Core, and the Genomics and Biomarkers Core. During the first year we will train nine Junior Scholars and support seven external studies, three research development projects, two pilot studies, one exploratory study and nine small pilot/exploratory studies. A major strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects and investigators that address one common research theme to be explored through the whole spectrum of biomedical investigation.

描述（由申请人提供）：佛罗里达大学老年美国人独立中心（OAIC）的使命是评估老年人身体残疾的危险因素，开发和测试有效的预防和康复疗法，并在研究中培训新的研究人员，从衰老和残疾，同时发展其领导才能。我们的策略是吸引来自各种行为，临床和基础科学学科的研究和研究人员，以研究衰老的研究，该研究的重点是共同的研究主题，这反过来又使我们能够完成我们的使命。将使用跨学科方法来追求“肌肉减少症，预防和康复残疾”的主题，该方法遍历整个生物医学研究的范围，包括分子生物学，动物研究，临床研究，行为科学和流行病学。该研究主题旨在解决OAIC计划的一般目标，即增加科学知识，从而导致维持或恢复老年人独立性的更好方法。我们的研究目标是（1）使用转化研究（基本学科和临床学科之间）评估多个因素，例如生物学，遗传，合并，社会心理和行为，导致肌肉减少症，身体功能下降以及对残疾和残疾的发展（2）在针对肌肉减少症的临床和临床前研究干预措施中开发并可靠地测试，以防止，延迟或恢复与年龄相关的身体机能下降以及对残疾的进展。为了解决这些目标，拟议的OAIC将包括以下综合核心，该核心将支持研究人员，初级学者，基础设施和服务：领导力和行政核心，研究职业发展核心，飞行员 /探索性研究核心，临床研究核心，临床前研究核心，生物统计学和数据管理核心，招聘核心以及基因组学和生物标志物核心。在第一年，我们将培训九名初级学者，并支持七项外部研究，三项研究开发项目，两项试点研究，一项探索性研究和九个小型试点/探索性研究。拟议的OAIC的主要优势是跨学科核心，项目和调查人员的协同行动，该行动通过整个生物医学范围来探讨一个共同的研究主题 调查。