Oxidative damage, disability and mortality in elders

老年人的氧化损伤、残疾和死亡

• 批准号: 7452238
• 负责人: Marco Pahor
• 金额: $ 26.3万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7452238
• 关键词: 11-dehydro-thromboxane B2; Address; African American; Age; Aging; Ancillary Study; Antioxidants; Behavioral; Biological; Biological Factors; Biological Markers; Blood Platelets; Body Composition; Body Weight Changes; Cardiovascular Diseases; Cardiovascular system; Characteristics; Clinic Visits; Clinical; Cohort Studies; Condition; Data; Diabetes Mellitus; Disabled Persons; Disease; Disruption; Elderly; Electrons; Enrollment; Equilibrium; Event; Free Radical Scavenging; Free Radicals; Future; Gender; Habits; Health; Healthcare; Inflammation; Inflammatory; Interleukin-6; Intervention; Lead; Lung; Lung diseases; Malignant Neoplasms; Measures; Mediating; Mediator of activation protein; Metabolic Diseases; Muscle; Numbers; Participant; Pathway interactions; Performance; Persons; Physical Function; Physical activity; Physiological; Platelet Activation; Play; Population; Population Study; Predictive Value; Prevention; Preventive Intervention; Process; Production; Public Health; Research; Research Personnel; Risk; Risk Factors; Role; Sampling; Serum; Smoke; Smoking; Staging; System; Testing; Thinking; Urine; Weight Gain; age related; base; cohort; cost; dietary restriction; disability; follow-up; functional status; improved; indexing; mortality; prevent; programs; promoter; prospective; racial difference; smoking cessation; social; urinary

DESCRIPTION (provided by applicant): Mobility disability is an early marker of the disablement process in older adults, and represents a major risk factor for physical disability and mortality. However, pathophysiological mechanisms responsible for the onset of mobility limitation are still largely unknown. Oxidative damage, responsible for the disruption of the equilibrium of biological systems by damaging major constituent molecules, might play an important role in the pathway leading to major health-related events. It has been suggested the existence of a vicious cycle involving oxidative damage, platelet activation and inflammation as promoter of pathophysiological changes occurring with aging. We propose to conduct data and biological sample analyses to evaluate whether oxidative damage and platelet activation markers are predictors for the onset of mobility disability and mortality in 2,345 well- functioning persons enrolled in the Health Aging and Body Composition study. Secondary objectives are to evaluate the relationship of markers of oxidative damage and platelet activation with 1) biological factors (inflammation, body composition), 2) behavioral factors (physical activity, weight gain, smoking habit), and 3) clinical conditions (cardiovascular disease, diabetes, cancer, pulmonary disease) potentially mediating the onset of mobility disability and mortality. Results of the proposed study will lead to the identification of 1) mechanisms that may promote the disabling process, 2) biological markers that identify subjects at risk of health-related events, 3) new potential targets and candidates for interventions to prevent mobility disability and mortality.

描述（由申请人提供）：流动性残疾是老年人残障过程的早期标记，代表了身体残疾和死亡率的主要危险因素。然而，导致迁移率发作的病理生理机制仍然在很大程度上未知。氧化损伤通过损害主要组成分子而导致生物系统平衡的破坏可能在导致主要健康相关事件的途径中起重要作用。已经提出，存在涉及氧化损伤，血小板激活和炎症的恶性循环，作为随着衰老而发生的病理生理变化的启动子。我们建议进行数据和生物样品分析，以评估氧化损伤和血小板激活标志物是否是2,345名入学型健康衰老和人体组成研究中运作障碍和死亡率发作的预测指标。次要目标是评估氧化损伤和血小板激活标记与1）生物学因素（炎症，身体成分）的关系，2）行为因素（体育活动，体重增加，吸烟习惯）和3）临床疾病（心血管疾病） ，糖尿病，癌症，肺部疾病）可能介导活动性残疾和死亡率的发作。拟议研究的结果将导致鉴定1）可能促进残疾过程的机制，2）鉴定出与健康相关事件风险的受试者的生物标记物，3）3）新的潜在目标和候选者，以防止出行残疾和候选人死亡。