Recipient Epidemiology and Donor Evaluation Study III (REDS-III) Internat'l Site

受赠者流行病学和捐助者评估研究 III (REDS-III) 国际网站

• 批准号: 8912322
• 负责人: EDWARD MURPHY
• 金额: $ 60.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8912322
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adult; Affect; Alloimmunization; Amendment; Area; Basic Science; Behavior; Biological; Biological Sciences; Blood; Blood Banks; Blood Donations; Blood Transfusion; Blood donor; Blood donor screening; Books; Budgets; Cataloging; Catalogs; Characteristics; Clinical Research; Clinical Sciences; Code; Collaborations; Collection; Confidentiality; Contractor; Contracts; Country; Data; Data Collection; Data Coordinating Center; Data Element; Data Set; Databases; Development; Education; Educational Activities; Ensure; Epidemic; Epidemiologic Studies; Epidemiology; Evaluation Studies; Goals; HIV; HIV-1; HIV-2; Health Insurance Portability and Accountability Act; Health Personnel; Incidence; Income; Infection; Infectious Agent; Informed Consent; Institution; Institutional Review Boards; International; Knowledge; Laboratories; Laboratory Study; Language; Leadership; Location; Manuals; Medical; Medicine; Methodology; Monitor; National Heart, Lung, and Blood Institute; Office Management; Participant; Pathologic; Patient Care; Patients; Performance; Policy Developments; Prevalence; Principal Investigator; Procedures; Process; Protocols documentation; Public Health; Publications; Questionnaires; Reporting; Research; Research Activity; Research Methodology; Research Personnel; Risk; Risk Factors; Safety; Sampling; Site; Specimen; Surveys; Technical Expertise; Test Result; Testing; Training; Training and Education; Transfusion; Translating; Translational Research; Vascular blood supply; Work; Writing; base; computerized data processing; evidence base; evidence based guidelines; improved; interest; meetings; member; operation; population based; prevent; programs; repository; research study; response; sample collection; symposium; transmission process

The objectives of the REDS-III program are to ensure safe and effective blood banking and transfusion medicine practices through a comprehensive, multi-targeted strategy involving basic, translational, and clinical research to improve the benefits of transfusion while reducing its risks. Improving blood component safety and availability in the U.S. and internationally through the conduct of epidemiologic, survey, and laboratory studies is the cornerstone of the REDS program. Transfusion therapy is the most commonly employed, and, arguably, one of the least understood medical procedures in the U.S. affecting about five million recipients annually. This research program is not only critical to public health in the U.S. but also to countries struggling with the HIV epidemic where blood safety and availability are major concerns. The REDS-III program is comprised of one Data Coordinating Center (DCC), one Central Laboratory, four domestic hubs, and three international collaborative programs involving U.S. investigators and investigators at international blood centers. The REDS-III program will target the following blood banking and transfusion medicine areas: donor targeted strategies; blood banking; transfusion practices in adult patients; and education and training. The goal of the International program is to address scientific questions to improve the safety and adequacy of the blood supply in selected low or middle income countries affected by the HIV/AIDS epidemic. The REDS-III international sites shall conduct epidemiologic, laboratory, and survey research primarily on blood donors with a major research focus on reducing and preventing the transmission of HIV/AIDS and other known and emerging infectious agents through transfusion. Studies in transfusion recipients may also be conducted. The major objectives of the research in the international program are: 1) assess and monitor the prevalence and incidence of HIV-1, HIV-2 and other existing as well as newly discovered infectious agents that pose a threat to blood safety; 2) assess risks of transfusion-transmitted infections; 3) assess the impact of existing and new blood donor screening methodologies on blood safety and availability; 4) evaluate characteristics and behaviors of blood donors including risk factors for acquiring HIV and other blood-borne agents; and 5) evaluate the donation process for ways to improve the safety and adequacy of the blood supply. Some studies may also address transfusion recipient safety concerns such as evaluating non-infectious transfusion risks (e.g., alloimmunization) and ways to reduce their occurrence.

REDS-III计划的目标是通过一项涉及基本，转化和临床研究的全面，多目标的策略来确保安全有效的血液库和输血医学实践，以提高输血的好处，同时降低其风险。通过流行病学，调查和实验室研究，改善美国和国际上的血液成分安全性和国际上的可用性是REDS计划的基石。输血疗法是最常见的，并且可以说是美国最了解的医疗程序之一，每年都会影响约500万接受者。该研究计划不仅对美国的公共卫生至关重要，而且对在艾滋病毒流行病上挣扎的国家是主要问题。 REDS-III计划由一个数据协调中心（DCC），一个中央实验室，四个国内枢纽和三个国际合作计划组成，其中涉及国际血液中心的美国调查人员和研究人员。 REDS-III计划将针对以下血液银行和输血医学领域：捐助者针对性的策略；血库；成年患者的输血习惯；以及教育和培训。国际计划的目的是解决科学问题，以提高受艾滋病毒/艾滋病流行影响的选定低收入或中等收入国家的血液供应的安全性和充分性。红色III国际遗址应主要针对献血者进行流行病学，实验室和调查研究，主要研究重点是减少和防止通过输血传播HIV/AIDS以及其他已知和新兴的感染因素。也可以在输血接受者中进行研究。 国际计划中该研究的主要目标是：1）评估和监测HIV-1，HIV-2以及其他现有的以及新发现的感染者的患病率和发病率，对血液安全构成威胁； 2）评估输血传播感染的风险； 3）评估现有和新的献血者筛查方法对血液安全和可用性的影响； 4）评估献血者的特征和行为，包括获取艾滋病毒和其他血液传播药物的危险因素； 5）评估捐赠过程，以提高血液供应的安全性和充分性。一些研究还可以解决输血接受者的安全问题，例如评估非感染输血风险（例如，同种免疫化）以及减少其发生的方法。