Recipient Epidemiology and Donor Evaluation Study III (REDS-III) Domestic Hub

受赠者流行病学和捐助者评估研究 III (REDS-III) 国内中心

基本信息

批准号：
8844815
负责人：
EDWARD MURPHY
金额：
$ 107.48万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-15 至 2017-03-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8844815
关键词：
Adult Affect Allogenic Amendment Area Basic Science Biological Sciences Blood Blood Banks Blood Donations Blood Transfusion Cancer Center Cardiac Surgery procedures Clinical Research Clinical Sciences Collection Community Hospitals Confidentiality Contractor Contracts Country Data Data Collection Data Coordinating Center Data Element Data Security Development Education Educational Activities Ensure Epidemic Epidemiology Evaluation Studies Grant HIV Health Insurance Portability and Accountability Act Health Personnel Hospitals Institutional Review Boards Intensive Care Units International Investigation K-Series Research Career Programs Knowledge Laboratories Laboratory Study Leadership Manuals Medical Medicine Mentors National Heart, Lung, and Blood Institute Orthopedic Surgery procedures Outpatients Participant Pathologic Patient Care Patients Performance Policy Developments Population Principal Investigator Procedures Process Protocols documentation Public Health Publications Research Research Activity Research Methodology Research Personnel Risk Safety Series Services Shipping Ships Surveys System Training Training and Education Transfusion Translational Research Trauma Voting Work base data management evidence base evidence based guidelines improved meetings member oncology operation population based programs repository research study symposium tertiary care

项目摘要

The objectives of the REDS-III program are to ensure safe and effective blood banking and transfusion medicine practices through a comprehensive, multi-targeted strategy involving basic, translational, and clinical research to improve the benefits of transfusion while reducing its risks. Improving blood component safety and availability in the U.S. and internationally through the conduct of epidemiologic, survey, and laboratory studies is the cornerstone of the REDS program. Transfusion therapy is the most commonly employed, and, arguably, one of the least understood medical procedures in the U.S. affecting about five million recipients annually. This research program is not only critical to public health in the U.S. but also to countries struggling with the HIV epidemic where blood safety and availability are major concerns. The REDS-III program is comprised of one Data Coordinating Center (DCC), one Central Laboratory, four domestic hubs, and three international collaborative programs involving U.S. investigators and investigators at international blood centers. The REDS-III program will target the following blood banking and transfusion medicine areas: donor targeted strategies; blood banking; transfusion practices in adult patients; and education and training.

REDS-III 计划的目标是通过涉及基础、转化和临床研究的全面、多目标策略，确保安全有效的血库和输血医学实践，以提高输血的益处，同时降低其风险。通过流行病学、调查和实验室研究来提高美国和国际上血液成分的安全性和可用性是 REDS 计划的基石。输血疗法是最常用的治疗方法，也可以说是美国最不为人所知的医疗程序之一，每年影响约 500 万接受者。该研究计划不仅对美国的公共卫生至关重要，而且对那些与艾滋病毒流行作斗争的国家也至关重要，因为血液安全和供应是这些国家的主要关注点。 REDS-III 项目由 1 个数据协调中心 (DCC)、1 个中心实验室、4 个国内中心以及 3 个涉及美国研究人员和国际血液中心研究人员的国际合作项目组成。 REDS-III 计划将针对以下血库和输血医学领域：针对捐助者的策略；血库；成年患者的输血实践；以及教育和培训。