ESTIMATES OF HERITABILITY COEFFICIENTS IN FEMALE RHESUS MACAQUES

雌性恒河猴遗传系数的估计

• 批准号: 8358106
• 负责人: Hans Michael Kubisch
• 金额: $ 3.72万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358106
• 关键词: Age; Animal Model; Birth; Birth Intervals; Cessation of life; Data; Daughter; Female; First Births; Funding; Genetic; Grant; Heritability; Infant; Longevity; Macaca mulatta; Methods; National Center for Research Resources; Parents; Postpartum Period; Primates; Principal Investigator; Productivity; Reporting; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; male; programs; reproductive; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Introduction: We have expanded our study to determine heritability coefficients of a number of reproductive parameters of captive female rhesus macaques (Macaca mulatta) to include phenotypic and genetic correlations. Methods: The data used to estimate heritability coefficients and phenotypic correlations contained 7,829 births, 1,898 females and 1,227 grand dams. Infants were born from 1982 through 2007. The MTDFREML animal model program was used to estimate heritability. Because no male parents were identified, the numerator relationship matrix contained all females involving maternal half-sib and daughter-dam relationships. Reproductive traits included female age at the birth of the first, second and last infant, age at death, inter-birth intervals, number of infants born per female and infant survival. Results/Discussion: Heritability estimates were generally small, ranging from 0.000 ¿ 0.072 for postpartum birth interval following the birth of the first infant to 0.325 ¿ 0.143 for a female's age at death. Estimates for heritability for female longevity traits and for productivity were moderate in size and larger than for most reproductive traits. Phenotypic correlations varied from near zero to 0.900 (P 0.01) between number of infants born and dam age at death. Genetic correlations were small with large standard errors. The heritability estimates reported here appear reasonable and tend to be similar to those for reproductive traits in other species.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供 该子项目的主要支持。 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源的子项目可能列出的总成本。 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 简介：我们扩大了研究范围，以确定圈养雌性恒河猴（Macaca mulatta）的许多生殖参数的遗传力系数，包括表型和相关遗传学方法：用于估计遗传力系数和表型相关性的数据包含 7,829 只出生，1,898 只。从 1982 年到 2007 年，共有 1,227 只母猪出生。使用 MTDFREML 动物模型程序来估计遗传力，因此分子关系矩阵包含所有女性母亲的同父异母关系和女儿-母亲关系，生殖特征包括第一、第二和最后一个婴儿出生时的女性年龄。 、死亡年龄、生育间隔、每名女性生育的婴儿数量以及婴儿存活率。 结果/讨论：遗传力估计值通常很小，范围从 0.000 ¿第一个婴儿出生后的产后分娩间隔为 0.072 至 0.325 ¿女性死亡年龄的估计值为 0.143，女性长寿性状和生产力的遗传力估计值中等，并且大于大多数生殖性状。出生婴儿数和损伤年龄之间的表型相关性从接近零到 0.900（P < 0.01）。死亡时的遗传相关性很小，但标准误差很大。这里报告的遗传力估计似乎是合理的，并且往往与其他物种的繁殖性状相似。