ESTIMATES OF HERITABILITY COEFFICIENTS IN FEMALE RHESUS MACAQUES

雌性恒河猴遗传系数的估计

• 批准号: 7958698
• 负责人: Hans Michael Kubisch
• 金额: $ 5.8万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958698
• 关键词: Age; Behavioral; Birth; Birth Intervals; Birth Records; Breeding; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Data; Data Set; Family; Female; First Births; Funding; Genotype; Grant; Heritability; Infant; Institution; Macaca mulatta; Methods; Parents; Postpartum Period; Primates; Productivity; Records; Research; Research Personnel; Resources; Source; Statistical Models; United States National Institutes of Health; Variant; male; reproductive; response; tool; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: A study was conducted on captive rhesus macaque (Macaca mulatta) to estimate heritability of a number of reproductive parameters. Methods: Reproductive records from a colony of Indian rhesus macaques were available from the years 1970 to 2008. A total of 3,569 females produced 16,006 birth records during this period. Records included identification of female and infant, but not the male parent of the infant. All reproductive records were assumed to be a function of the female genotype. Therefore, identification of the dam of each female resulted in maternal half-sib families with the grand dam as the common parent. A total of 1,300 grand dams were identified in the data set. A total of 9,010 records from 2,081 dams had grand dam identification. Results/Discussion: The statistical model for each dam response included grand dam as a random source of variation and various fixed sources of variation that were found to influence variation in the particular response. The standard error of each heritability estimate was determined using 32*h2 /N where N is the number of records analyzed for that trait and 32*h2 /N is an estimate of the variance of heritability. Coefficients of heritability of lifetime productivity proved to be moderate. These included a female's age at death (h2 = 0.60¿ 0.11), her age at her last birth (h2 = 0.68 ¿ 0.12) and the number of infants produced during her lifetime (h2 = 0.61 ¿ 0.11). In contrast, traits such as postpartum age at first birth (h2 = 0.24 ¿ 0.06), birth interval (h2 = 0.15 ¿ 0.03), survival of the infant to 30 days (h2 = 0.14 ¿ 0.02) and 1 year (h2 = 0.06 ¿ 0.02) had very low heritability coefficients. Heritability estimates in association with behavioral data may provide useful tools in management of breeding colonies, particularly for the selection and retention of breeding females.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 中心，不一定是研究者的机构。 背景：对圈养恒河猴（Macaca mulatta）进行了一项研究，以估计许多生殖参数的遗传力。方法：从 1970 年到 2008 年，有一群印度恒河猴的生殖记录。总共产下 3,569 只雌性恒河猴。这一时期的 16,006 份出生记录包括女性和婴儿的身份，但不包括婴儿的父亲。所有生殖记录均被假定为是。因此，对每只雌性的母亲进行鉴定都会产生以大母亲为共同亲本的母系同父异母家庭。数据集中总共鉴定了 1,300 个大母亲。来自 2,081 个大坝的大坝识别结果/讨论：每个大坝响应的统计模型包括作为随机变异源的大坝和被发现影响变化的各种固定变异源。每个遗传力估计的标准误差是使用 32*h2 /N 确定的，其中 N 是针对该性状分析的记录数，32*h2 /N 是遗传力方差的估计。 终生生产力的遗传系数被证明是适中的，其中包括女性的死亡年龄（h2 = 0.60¿ 0.11）、她最后一次生育的年龄（h2 = 0.68 ¿ 0.12）以及她一生中生育的婴儿数量（h2）。 = 0.61 ¿ 0.11 相比之下，第一胎产后年龄等特征 (h2 = 0.24)。与行为数据相关的遗传力估计可以为繁殖群体的管理提供有用的工具，特别是对于繁殖雌性的选择和保留。