Molecular Pathology of Cancer

癌症的分子病理学

基本信息

批准号：
8350091
负责人：
Michael Emmert-Buck
金额：
$ 36.39万
依托单位：
DIVISION OF CLINICAL SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8350091
关键词：
13q12 Affect Allelotyping Androgens Biotechnology CCR Candidate Disease Gene China Chromosome Band Clinical Data Development Diabetes Mellitus Digestive System Disorders Disease Epigenetic Process Esophageal Neoplasms Esophageal Squamous Cell Carcinoma Evaluation Family history of Gene Expression Genes Genomics Goals Human Individual Inherited Institutes Kidney Diseases Malignant Neoplasms Malignant neoplasm of prostate Measurement Menin Methylation Molecular Molecular Profiling Multiple Endocrine Neoplasia Type 1 National Human Genome Research Institute Nature Neuroendocrine Tumors Pathogenesis Patients Population Prostate Proteins Province Specimen Syndrome Therapeutic Intervention Transcript Tumor Suppressor Genes United States National Institutes of Health Urologic Oncology base cancer prevention high risk human tissue interest molecular pathology new technology novel diagnostics prognostic tumor tumorigenesis working group

项目摘要

As part of an integrated effort between the Pathogenetics Unit and the Urologic Oncology Branch, CCR, we identified a large number of deregulated transcripts and proteins in human prostate cancer, including a gene set that segregates high- and moderate grade cancer, and a gene set that segregates androgen-dependent and androgen-independent disease. Efforts are continuing to better understand the molecular nature of prostate tumorigenesis, and to identify gene expression profiles associated with clinically aggressive cancer. Additionally, we discovered a new type of epigenetic methylation field in prostate cancer that may assist in understanding the pathogenesis of the tumor microenvironment. In a search for genes involved in the development of esophageal tumors, we are collaborating with the Cancer Prevention Studies Branch, CCR, to examine the molecular basis of esophageal squamous cell carcinoma (ESCC) in a high-risk population in Shanxi province in China. Allelotype comparison of patients with and without a family history of ESCC identified a region on chromosome band 13q12 that may harbor a familial tumor suppressor gene. Efforts are underway to analyze several candidate genes in the genomic region of interest. Multiple Endocrine Neoplasia Type I (MEN1) is an inherited syndrome characterized by development of neuroendocrine tumors in affected individuals. The responsible gene was discovered in 1997 by the NIH MEN1 working group, including the Pathogenetics Unit and groups from the National Human Genome Research Institute, the National Center for Biotechnology Information, and the National Institute of Diabetes and Digestive and Kidney Diseases. Current efforts of the Pathogenetics Unit include immunohistochemical evaluation of menin in human tissues.

作为病原体单元与泌尿科肿瘤学分支之间的综合努力的一部分，我们在人类前列腺癌中确定了大量失调的转录本和蛋白质，包括一个基因组，该基因将高和中等级别的癌症分离出来，以及一个基因群体，该基因将雌激素依赖性依赖于雌激素依赖于依赖型和依赖于依赖型和依赖的疾病。努力继续更好地理解前列腺肿瘤发生的分子性质，并确定与临床攻击性癌症相关的基因表达谱。此外，我们在前列腺癌中发现了一种新型的表观遗传甲基化场，可能有助于理解肿瘤微环境的发病机理。在寻找参与食管肿瘤发展的基因时，我们正在与CCR癌症预防研究分支合作，以检查中国山西省高危人群中食管鳞状细胞癌（ESCC）的分子基础。具有和没有ESCC家族病史的患者的特eltype比较确定了可能带有家族性肿瘤抑制基因的染色体带13q12的区域。正在努力分析感兴趣的基因组区域中的几个候选基因。多内分泌肿瘤I型（MEN1）是一种遗传综合征，其特征是受影响个体中神经内分泌肿瘤的发展。 NIH MEN1工作组于1997年发现了负责的基因，包括致病学部门和国家人类基因组研究所，国家生物技术信息中心以及国家糖尿病和消化和肾脏疾病的组。病原体单位的当前努力包括对人体组织中梅宁的免疫组织化学评估。