TIMED BREEDING CORE

定时育种核心

• 批准号: 7958573
• 负责人: Hans Michael Kubisch
• 金额: $ 6.04万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958573
• 关键词: Acquired Immunodeficiency Syndrome; Breeding; Computer Retrieval of Information on Scientific Projects Database; Conceptions; Dose; Female; Funding; Grant; Hour; Human; Infant; Injection of therapeutic agent; Institution; Intramuscular Injections; Live Birth; Methods; Pregnancy; Primates; Procedures; Progesterone; Research; Research Personnel; Resources; Seasons; Source; Time; Ultrasonography; United States National Institutes of Health; gene therapy; male; ovulation time; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: The timed-breeding program at the Tulane National Primate Research Center uses exogenous progesterone administration to control the time of ovulation. Methods: Human progesterone is administered by intramuscular injection at a dose of 5mg. The female is placed with the male 14 days after the last injection. Ultrasonography conducted 24 or 31 days after placing the female with the male confirms that pregnancy generally occurs 4 days after introduction to the male. This procedure allows for the efficient use of the males and provides a conception date+24 hours. Results/Discussion: In the spring/summer of 2008, 24 live births occurred as a result of time breeding efforts. These infants were assigned to either R. Veazey (AIDS research) or D. Phinney (gene therapy). For the 2008 breeding season, 15 females and 5 males are being used to provide infants to support a project of D. Phinney. Currently there are 2 confirmed pregnancies. The other females are awaiting ultrasounds and/or being placed with a male for breeding.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 背景：杜兰国家灵长类动物研究中心的定时繁殖计划使用外源性黄体酮管理来控制排卵时间。 方法：人黄体酮通过肌肉注射给药，剂量为5mg。 最后一次注射后 14 天，将雌性与雄性放在一起。 将雌性与雄性交配后 24 或 31 天进行的超声检查证实，怀孕通常发生在引入雄性后 4 天。 该程序可以有效利用雄性并提供受孕日期+24 小时。 结果/讨论：2008 年春/夏，由于定时配种的努力，发生了 24 例活产。 这些婴儿被分配到 R. Veazey（艾滋病研究）或 D. Phinney（基因治疗）组。 2008 年繁殖季节，15 只雌性和 5 只雄性被用来产仔，以支持 D. Phinney 的项目。 目前已有2人确认怀孕。 其他雌性正在等待超声波检查和/或与雄性一起繁殖。