Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

• 批准号: 8696566
• 负责人: Shreyas S Vasanawala
• 金额: $ 36.68万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8696566
• 关键词: Abdomen; Acceleration; Address; Adult; Algorithms; Anatomic structures; Anesthesia procedures; Appendicitis; Body Image; Breathing; Calibration; Child; Child health care; Childhood; Clinic; Clinical; Clinical Research; Data; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Elements; Financial compensation; Freezing; Frequencies; Healthcare; Image; Incidence; Ionizing radiation; Lead; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Methods; Modality; Morphologic artifacts; Motion; Motivation; Patients; Population; Protocols documentation; Radiation; Resolution; Respiration; Risk; Role; Scanning; Sedation procedure; Sensitivity and Specificity; Signal Transduction; Slice; Solutions; Speed; Structure; System; Techniques; Technology; Three-Dimensional Imaging; Time; Validation; Weight; Work; X-Ray Computed Tomography; base; cancer risk; clinical practice; community setting; cost effective; data space; design; design and construction; experience; heart motion; image reconstruction; imaging modality; improved; innovation; novel; novel strategies; parallel computer; public health relevance; reconstruction; research and development; respiratory; skills; soft tissue; spatiotemporal; success; validation studies

DESCRIPTION (provided by applicant): Motivation: This is a competing renewal of our successful project Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast and high resolution for children, without the ionizing radiation and cancer risk of CT. However, its use has been limited as children often cannot voluntarily suspend respiration or tolerate long exams. MRI often requires anesthesia with attendant risk; hence, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. The previous project addressed these concerns by creating a dedicated pediatric imaging system. Highly parallel, high SNR 3T receive arrays were designed and constructed specifically for pediatric body imaging. The high SNR was used to accelerate scans reconstructed with a combination of parallel imaging, new motion correction algorithms, and compressed sensing (CS). Parallel computing reconstruction algorithms produced 3D volumes in 1 minute. The resulting system is being used extensively in clinical practice, significantly reducing anesthesia, and has markedly increased our abdominal MRI utilization. Key technologies are now being commercialized with GE Healthcare, including the pediatric receive array, CS, and coil compression. Despite significant progress, with markedly reduced scan times, anesthesia has not been eliminated. Patient motion remains the main limitation. Therefore the major emphasis here is addressing motion through robust imaging, motion correction, and dynamic MRI. This will (1) extend the benefits of MRI to younger, less cooperative patients, (2) allow the correction and depiction of respiratory motion, and (3) provide the temporal resolution that captures the faster contrast dynamics in children for free-breathing 3D dynamic studies. Approach: The project has three interrelated development aims, validated by clinical studies. Aim 1 is to enable robust acquisition and reconstruction in the presence of motion in 3D studies. This uses robust parallel imaging calibration and reconstruction, outlier insensitive optimization and a new approach for measuring localized non-rigid motion throughout the body using array coil elements. A second aim is to develop ultrafast multi band 2D approaches for faster imaging of uncooperative patients. This freezes motion in each set of slices, simplifying motion correction over the volume. The impact of these developments in the clinic will then be assessed in the setting of appendicitis, a representative common and challenging pediatric abdominal imaging application. Then we will exploit temporal correlations and dynamics in time-resolved 3D contrast studies and further speed 2D scans, and again assess the impact in children with suspected appendicitis. Significance: This work will lead to fast, robust, broadly-applicable pediatric body MRI protocols with less anesthesia, making MRI safer, cheaper, and more available to children, transforming it into a workhorse modality and decreasing CT radiation burden. The techniques will facilitate wide application in the community setting and permit new MRI applications, for both pediatric and adult disease.

描述（由申请人提供）：动机：这是我们成功项目快速稳健的儿科MRI，R01 EB 009690的竞争续约。 MRI为儿童提供了出色的软组织对比度和高分辨率，而没有电离辐射和CT癌症风险。但是，它的使用受到限制，因为儿童通常不能自愿暂停呼吸或容忍长期考试。 MRI经常需要麻醉，带有随之而来的风险；因此，儿童通常缺乏横截面成像的好处，或暴露于电离辐射。以前的项目通过创建专用的儿科成像系统来解决这些问题。高度平行的高SNR 3T接收阵列是专门针对小儿体成像的。高SNR用于通过平行成像，新运动校正算法和压缩传感（CS）的组合加速扫描。平行计算重建算法在1分钟内产生了3D体积。所得系统广泛用于临床实践，大大降低了麻醉， 并明显增加了我们的腹部MRI利用率。关键技术现在正在通过GE Healthcare进行商业化，包括儿科接收阵列，CS和线圈压缩。尽管取得了重大进展，但扫描时间明显减少，但尚未消除麻醉。患者运动仍然是主要限制。因此，这里的主要重点是通过强大的成像，运动校正和动态MRI来解决运动。这将（1）将MRI的好处扩展到年轻的，较少的合作患者，（2）允许进行更正 呼吸运动的描述，以及（3）提供了时间分辨率，该分辨率捕获了自由呼吸3D动态研究儿童中更快的对比动力学。方法：该项目具有三个相互关联的开发目的，并通过临床研究验证。 AIM 1是在3D研究中有运动的情况下实现强大的采集和重建。这使用了可靠的并行成像校准和重建，异常不敏感的优化以及一种使用阵列线圈元件在整个身体中测量局部非刚性运动的新方法。第二个目的是开发超快多个频段2D方法，以更快地对不合作患者进行成像。这将在每组切片中冻结运动，从而简化了体积上的运动校正。然后，将在诊所中这些发展的影响在阑尾炎的情况下进行评估，阑尾炎是一种代表性的常见且具有挑战性的腹部成像。然后，我们将利用时间分辨的3D对比研究和进一步速度2D扫描的时间相关性和动力学，并再次评估对可疑阑尾炎儿童的影响。意义：这项工作将导致麻醉较少的快速，健壮，广泛的小儿MRI方案，使儿童更安全，更便宜，更便宜，更适合儿童使用，将其转变为工作马方式并减少CT辐射负担。这些技术将促进社区环境中的广泛应用，并允许为儿科和成人疾病提供新的MRI应用。