Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

基本信息

批准号：
8696566
负责人：
Shreyas S Vasanawala
金额：
$ 36.68万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8696566
关键词：
Abdomen Acceleration Address Adult Algorithms Anatomic structures Anesthesia procedures Appendicitis Body Image Breathing Calibration Child Child health care Childhood Clinic Clinical Clinical Research Data Development Diagnosis Diagnostic Diagnostic Imaging Disease Elements Financial compensation Freezing Frequencies Healthcare Image Incidence Ionizing radiation Lead Magnetic Resonance Imaging Malignant Neoplasms Measures Methods Modality Morphologic artifacts Motion Motivation Patients Population Protocols documentation Radiation Resolution Respiration Risk Role Scanning Sedation procedure Sensitivity and Specificity Signal Transduction Slice Solutions Speed Structure System Techniques Technology Three-Dimensional Imaging Time Validation Weight Work X-Ray Computed Tomography base cancer risk clinical practice community setting cost effective data space design design and construction experience heart motion image reconstruction imaging modality improved innovation novel novel strategies parallel computer public health relevance reconstruction research and development respiratory skills soft tissue spatiotemporal success validation studies

项目摘要

DESCRIPTION (provided by applicant): Motivation: This is a competing renewal of our successful project Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast and high resolution for children, without the ionizing radiation and cancer risk of CT. However, its use has been limited as children often cannot voluntarily suspend respiration or tolerate long exams. MRI often requires anesthesia with attendant risk; hence, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. The previous project addressed these concerns by creating a dedicated pediatric imaging system. Highly parallel, high SNR 3T receive arrays were designed and constructed specifically for pediatric body imaging. The high SNR was used to accelerate scans reconstructed with a combination of parallel imaging, new motion correction algorithms, and compressed sensing (CS). Parallel computing reconstruction algorithms produced 3D volumes in 1 minute. The resulting system is being used extensively in clinical practice, significantly reducing anesthesia, and has markedly increased our abdominal MRI utilization. Key technologies are now being commercialized with GE Healthcare, including the pediatric receive array, CS, and coil compression. Despite significant progress, with markedly reduced scan times, anesthesia has not been eliminated. Patient motion remains the main limitation. Therefore the major emphasis here is addressing motion through robust imaging, motion correction, and dynamic MRI. This will (1) extend the benefits of MRI to younger, less cooperative patients, (2) allow the correction and depiction of respiratory motion, and (3) provide the temporal resolution that captures the faster contrast dynamics in children for free-breathing 3D dynamic studies. Approach: The project has three interrelated development aims, validated by clinical studies. Aim 1 is to enable robust acquisition and reconstruction in the presence of motion in 3D studies. This uses robust parallel imaging calibration and reconstruction, outlier insensitive optimization and a new approach for measuring localized non-rigid motion throughout the body using array coil elements. A second aim is to develop ultrafast multi band 2D approaches for faster imaging of uncooperative patients. This freezes motion in each set of slices, simplifying motion correction over the volume. The impact of these developments in the clinic will then be assessed in the setting of appendicitis, a representative common and challenging pediatric abdominal imaging application. Then we will exploit temporal correlations and dynamics in time-resolved 3D contrast studies and further speed 2D scans, and again assess the impact in children with suspected appendicitis. Significance: This work will lead to fast, robust, broadly-applicable pediatric body MRI protocols with less anesthesia, making MRI safer, cheaper, and more available to children, transforming it into a workhorse modality and decreasing CT radiation burden. The techniques will facilitate wide application in the community setting and permit new MRI applications, for both pediatric and adult disease.

描述（由申请人提供）：动机：这是我们成功项目快速稳健儿科 MRI，R01 EB009690 的竞争性更新。 MRI 为儿童提供卓越的软组织对比度和高分辨率，且没有 CT 的电离辐射和癌症风险。然而，它的使用受到了限制，因为儿童往往无法自愿暂停呼吸或忍受长时间的检查。 MRI 通常需要麻醉，并伴有风险；因此，儿童通常完全无法享受横截面成像的好处，或者暴露于电离辐射下。之前的项目通过创建专用的儿科成像系统来解决这些问题。高度并行、高 SNR 3T 接收阵列专为儿科身体成像而设计和构建。高信噪比用于加速结合并行成像、新运动校正算法和压缩感知 (CS) 重建的扫描。并行计算重建算法可在 1 分钟内生成 3D 体积。由此产生的系统广泛用于临床实践，显着减少麻醉，并显着提高了我们腹部 MRI 的利用率。 GE Healthcare 目前正在将关键技术商业化，包括儿科接收阵列、CS 和线圈压缩。尽管取得了重大进展，扫描时间显着减少，但麻醉尚未被消除。患者运动仍然是主要限制。因此，这里的重点是通过强大的成像、运动校正和动态 MRI 来解决运动问题。这将 (1) 将 MRI 的优势扩大到年轻、不太合作的患者，(2) 允许纠正以及呼吸运动的描述，(3) 提供时间分辨率，捕捉儿童的更快对比动态，以进行自由呼吸 3D 动态研究。方法：该项目具有三个相互关联的开发目标，并经过临床研究验证。目标 1 是在 3D 研究中存在运动的情况下实现稳健的采集和重建。它使用强大的并行成像校准和重建、异常值不敏感优化以及使用阵列线圈元件测量整个身体的局部非刚性运动的新方法。第二个目标是开发超快多波段二维方法，以便对不合作的患者进行更快的成像。这会冻结每组切片中的运动，从而简化了体积上的运动校正。然后将在阑尾炎的背景下评估这些发展对临床的影响，阑尾炎是一种具有代表性的常见且具有挑战性的儿科腹部成像应用。然后，我们将在时间分辨 3D 对比研究中利用时间相关性和动态，并进一步加速 2D 扫描，并再次评估对疑似阑尾炎儿童的影响。意义：这项工作将带来快速、稳健、广泛适用的儿科身体 MRI 方案，且麻醉更少，使 MRI 更安全、更便宜、更适合儿童使用，将其转变为主力模式并减少 CT 辐射负担。这些技术将促进在社区环境中的广泛应用，并允许新的 MRI 应用，用于儿科和成人疾病。