Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

• 批准号: 8035425
• 负责人: Shreyas S Vasanawala
• 金额: $ 34.6万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8035425
• 关键词: 8 year old; Acceleration; Adult; Age; Anatomic structures; Anatomy; Anesthesia procedures; Body Image; Child; Childhood; Clinical Research; Data; Development; Diagnosis; Diagnostic; Disease; Dose; Elements; Failure; Financial compensation; Image; Ionizing radiation; Lead; Length; Magnetic Resonance Imaging; Malignant Neoplasms; Methods; Modality; Monitor; Morphologic artifacts; Motion; Noise; Patients; Pilot Projects; Population; Protocols documentation; Radiation; Radiation-Induced Cancer; Recruitment Activity; Resolution; Risk; Safety; Sampling; Sedation procedure; Signal Transduction; Speed; Structure; Techniques; Testing; Time; Vulnerable Populations; Weight; Work; X-Ray Computed Tomography; base; community setting; compliance behavior; cost effective; density; diagnostic accuracy; image reconstruction; imaging modality; improved; innovation; novel; novel strategies; public health relevance; reconstruction; research and development; research study; skills; soft tissue; tool

DESCRIPTION (provided by applicant): This work aims for rapid, robust pediatric body MRI. MRI is an excellent tool for diagnosis and monitoring of pediatric disease, offering superb soft tissue contrast and high anatomic resolution; unlike computed tomography (CT), particularly attractive is the lack of ionizing radiation, given the increased risk of children to radiation-induced cancer. However, the impact of MRI in children is limited by (1) lack of robustness from the technical demands and low signal to noise ratio (SNR) of imaging small moving structures in an often uncooperative patient, (2) long exams that limit access, cause motion artifacts, and often require anesthesia with attendant risk, and (3) research and development mostly focused on adults. Thus, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. Approach: This work will (1) increase SNR by developing high-density 3 Tesla receive coils optimized for children and (2) incorporate new k-space sampling strategies, advanced motion correction techniques, and novel non-linear parallel imaging reconstruction methods to reduce image reconstruction failure and motion artifacts, thereby increasing robustness. These two developments will enable a third development, (3) compressed sensing, which enables a further increase in imaging speed by exploiting image sparsity to undersample data without causing image artifacts. The three approaches will synergize for dramatic speed, resolution, and anatomic coverage improvements. Experiments will assess (1) SNR gains of a dedicated pediatric coil, (2) image quality of standard acceleration methods versus parallel imaging enhanced with incoherent sampling, pseudorandom ordering, motion- correction, and nonlinear reconstruction, (3) diagnostic equivalence between parallel imaging alone and further accelerated imaging from combined parallel imaging and compressed sensing, and (4) the ability of these methods to reduce anesthesia for pediatric MRI. Significance: This work will lead to fast, robust, broadly-applicable pediatric body MRI protocols with less anesthesia, making MRI safer, cheaper, and more available to children, transforming it into a workhorse modality and decreasing CT radiation burden. The techniques will demand less MRI operator skill, facilitating wide application in the community setting. Finally, faster imaging and motion compensation will permit new MRI applications, for both pediatric and adult disease. PUBLIC HEALTH RELEVANCE: Pediatric body MRI poses unique challenges of imaging small moving anatomic structures without patient cooperation, resulting in a need for anesthesia, long exam times, and lack of robustness. We will exploit synergies of high field strength, high density receive coils, new motion correction strategies, and novel imaging acceleration methods to dramatically improve image quality and speed. This work will ultimately enable more body MRI exams to be performed robustly without sedation or anesthesia, thus increasing MRI safety and availability and decreasing the dose of ionizing radiation from CT to a particularly vulnerable population.

描述（由申请人提供）：这项工作旨在快速，健壮的小儿身体MRI。 MRI是诊断和监测小儿疾病的绝佳工具，提供了超级软组织对比度和高解剖分辨率。与计算机断层扫描（CT）不同，尤其是缺乏电离辐射，鉴于儿童会增加辐射诱导的癌症的风险。但是，MRI对儿童的影响受（1）技术需求缺乏鲁棒性，而信号与噪声比（SNR）缺乏对通常不合作患者的小型移动结构的成像，（2）长期考试限制了限制访问动作，导致运动伪像，并且通常需要与随附风险进行麻醉以及（3）研究和发展的研究和发展。因此，儿童通常完全缺乏横截面成像的好处，或暴露于电离辐射。方法：这项工作将（1）通过开发高密度3 TESLA接收针对儿童优化的线圈以及（2）结合新的K空间采样策略，高级运动校正技术以及新型的非线性并行想象重建方法，以减少图像重建失败和运动性运动，从而提高了鲁棒性。这两个发展将使第三个发展，（3）压缩传感，这可以通过利用图像稀疏性来进一步提高成像速度，而不会引起图像伪影。这三种方法将协同速度，分辨率和解剖覆盖范围改进。实验将评估（1）SNR的专用小儿线圈的增长，（2）标准加速方法的图像质量与平行成像的图像质量与并行成像通过不一致的采样，伪序，运动校正，运动校正和非线性重构，（3）单独的诊断和进一步的诊断，并平行地想象在诊断的能力和进一步的诊断，从这些方法可以减少小儿MRI麻醉的方法。意义：这项工作将导致麻醉较少的快速，健壮，广泛的小儿MRI方案，使儿童更安全，更便宜，更便宜，更适合儿童使用，将其转变为工作马方式并减少CT辐射负担。这些技术将需要更少的MRI操作员技能，从而促进社区环境中的广泛应用。最后，更快的成像和运动补偿将允许针对儿科和成人疾病进行新的MRI应用。 公共卫生相关性：小儿身体MRI提出了成像小型移动解剖结构而无需患者合作的独特挑战，从而导致需要麻醉，长期考试时间和缺乏鲁棒性。我们将利用高磁场强度，高密度接收线圈，新运动校正策略和新型成像加速方法的协同作用，以显着提高图像质量和速度。这项工作最终将使更多的身体MRI检查能够在没有镇静或麻醉的情况下进行稳健进行，从而提高了MRI安全性和可用性，并减少了从CT到特别脆弱的人群的电离辐射剂量。