CD: Tissue Core

CD：组织核心

• 批准号: 8719566
• 负责人: Wilma Lingle
• 金额: $ 15.24万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-12 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8719566
• 关键词: Anatomy; Archives; Biostatistics Core; Blood; Cancer Center; Cancer Patient; Cells; Clinic; Clinical; Clinical Research; Collection; Communities; Confidentiality of Patient Information; DNA; Data; Evaluation; Freezing; Future; Goals; Immunohistochemistry; Laboratories; Leadership; Link; Malignant Neoplasms; Malignant neoplasm of pancreas; Mayo Clinic Cancer Center; Methodology; Molecular Analysis; Neoplasm Circulating Cells; Operative Surgical Procedures; Pancreas; Paraffin Embedding; Pathologist; Pathology; Patients; Preparation; Prevention; Procedures; Process; RNA; Records; Research; Research Activity; Research Personnel; Research Support; Resource Sharing; Resources; Serum; Services; Site; Slide; Specimen; Tissue Microarray; Tissues; Translational Research; anticancer research; base; digital imaging; human tissue; improved; laser capture microdissection; programs; sound; tissue processing; tissue registry

The goal of the Tissue Core is to provide investigators in the Pancreas SPORE with high quality patient data, DNA, RNA, serum, circulating tumor cells, and pancreas tissues from pancreatic cancer patients, and to make these resources available for future studies. The activities of the Tissue Core will be overseen under the combined leadership of Dr. W. Lingle, Director of the TACMA and Co-Director of the BAP Shared Resources of the Mayo Clinic Cancer Center, and Dr. T. Smyrk, anatomic pathologist. The activities of the Tissue Core will be conducted in a way that does not compromise patient confidentiality, yet will be as comprehensive as possible in the materials that are provided. The acquisition of human tissue and subsequent cellular/molecular analysis of that tissue within the context of pathology and patient data are key to many laboratory-based studies of cancer. The Mayo Clinic has a strong tradition of ethically sound support of research that links tissue acquisition and patient data records. Paraffin embedded tissues, histological slides, and associated patient charts from surgeries performed since the first decade of the 1900's are maintained in Mayo's Tissue Registry and the Mayo Archives. The Tissue and Cell Molecular Analysis (TACMA) Shared Resource of the Mayo Clinic Cancer Center is a resource of expertise and service for immunohistochemistry, laser capture microdissection, tissue microarray preparation, and digital imaging. Likewise, the Biospecimen Accessioning and Processing (BAP) Shared Resource of the Mayo Clinic Cancer Center is the primary site of accessioning and standardized processing of blood, frozen tissue, and other non-paraffin embedded specimens collected explicitly for research. New methodologies for biospecimen collection, processing, and analysis will be developed in the Tissue Core. These methodologies will be shared with other Mayo SPORE Tissue Cores and integrated with services offered by the BAP and TACMA Shared Resources. Tissue Core activities will be closely coordinated with the newly formed Clinical Research Core and with the Biostatistics Core to provide seamless linkage of clinical annotations with research biospecimens. Core D will be integrated with the existing tissue-oriented Cancer Center shared resources and the other scientific Cores in this SPORE in order to provide a coordinated, centralized, dedicated program for standardized collection, accessioning, processing, and evaluation of biospecimens and patient data from pancreatic cancer patients. Furthermore, the Tissue Core will make biospecimens collected for this SPORE available to the pancreas cancer research community in order to stimulate translational research with the goal of improving prevention and treatment of pancreatic cancer.

组织核心的目标是为胰腺 SPORE 的研究人员提供高质量的患者数据， 来自胰腺癌患者的 DNA、RNA、血清、循环肿瘤细胞和胰腺组织，以及 使这些资源可用于未来的研究。组织核心的活动将受到监督 TACMA 主任兼 BAP 联合主任 W. Lingle 博士的共同领导 梅奥诊所癌症中心和解剖病理学家 T. Smyrk 博士的资源。该组织的活动 Tissue Core 将以不损害患者机密性的方式进行，但将作为 所提供的材料尽可能全面。人体组织的获取和 随后在病理学和患者数据背景下对该组织进行细胞/分子分析是关键 许多基于实验室的癌症研究。梅奥诊所拥有道德健全支持的悠久传统 将组织采集和患者数据记录联系起来的研究。石蜡包埋组织，组织学 幻灯片以及自 1900 年代第一个十年以来进行的手术的相关患者图表 保存在梅奥组织登记处和梅奥档案馆中。组织和细胞分子分析 (TACMA) 梅奥诊所癌症中心的共享资源是专业知识和服务的资源 免疫组织化学、激光捕获显微切割、组织微阵列制备和数字成像。 同样，梅奥诊所癌症生物样本登记和处理 (BAP) 共享资源 中心是血液、冰冻组织等的加入和标准化处理的主要场所。 专门为研究而收集的非石蜡包埋标本。生物样本的新方法 收集、处理和分析将在组织核心中进行。这些方法将 与其他 Mayo SPORE 组织核心共享，并与 BAP 和 TACMA 提供的服务集成 共享资源。组织核心活动将与新成立的临床中心密切协调 研究核心和生物统计学核心提供临床注释与 研究生物样本。 Core D将与现有的以组织为导向的癌症中心共享 资源和该 SPORE 中的其他科学核心，以便提供协调、集中、 生物样本标准化采集、登记、处理和评估的专用程序 以及胰腺癌患者的患者数据。此外，组织核心将制作生物样本 收集的孢子可提供给胰腺癌研究界，以刺激 旨在改善胰腺癌预防和治疗的转化研究。