IMAGING

影像学

• 批准号: 7578736
• 负责人: Mark A. Mintun
• 金额: $ 21.67万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7578736
• 关键词: Aging; Anatomy; Anterior; Archives; Atrophic; Attention; Biological Markers; Biometry; Biostatistics Core; Brain imaging; Clinical; Computer software; Data; Data Set; Diffusion Magnetic Resonance Imaging; Early Diagnosis; Functional Imaging; Future; Goals; Hippocampus (Brain); Image; Impaired cognition; Intracranial Hemorrhages; Investigation; Manuals; Measurement; Participant; Positron-Emission Tomography; Predisposition; Process; Research; Research Personnel; Research Project Grants; Rest; Scanning; Seeds; Senile Plaques; Senile dementia; Staging; Surrogate Markers; Weight; Work; cerebral atrophy; healthy aging; infrastructure development; programs; web based interface; white matter

Structural imaging provides a means to visualize change in anatomy associated with cognitive decline (e.g., Project 3 "Attention Profiles in Healthy Aging and Early Stage DAT") and also candidate surrogate markers for detection of early-stage DAT in combination with other biomarkers (e.g., Project 2 "Antecedent biomarkers of AD in CSF"). The goal of the Core E: Imaging is to collect, store, and disseminate imaging data for the use of the present program project investigations and also to facilitate the development of infrastructure to support future imaging projects. The following Specific Aims will be pursued: 1. Structural imaging data on demented and nondemented participants will be collected, in close coordination with Core B: Clinical, at two-year longitudinal intervals. The structural imaging battery will include (i) multiple acquisitions of high contrast MP-RAGE images, (ii)3D T2 images for assessment of white matter. These images will be used for measurement of cortical and subcortical atrophy and assessment of white matter integrity, (iii)diffusion tensor imaging to assess white matter microstructural integrity, and (iv)T2-SWI images. In addition, functional imaging data on demented and nondemented participants will be collected. The functional imaging data will be BOLD images during rest to assess functional connectivity. 2. Research neuroradiological assessment will be made by board-certified neuroradiologists on all structural image data sets. 3. Structural data sets will be archived in conjunction with Core C: Biostatistics and made available via a web-based interface to investigators to pursue research projects. 4. Quantitative structural assessment will be provided for correlating imaging data with project-specific data including (i) automated estimates of whole- brain atrophy, (ii) manual estimates of hippocampal, entorhinal, frontal, and other cortical volumes, (iii) automated estimates of cortical and subcortical volumes derived from Freesurfer software (Fischl et al., 2002; Fischl et al., 2004; Desikan et al., 2006), and (iv) automated assessment of white matter hyperintensities. Quantitative functional assessment will also be provided for correlating imaging data with project-specific data and will include estimates of the functional connectivity between seed regions such as the hippocampus and the precuneus. 5. Working closely with Core C: Biostatistics and Core A: Administration, data will be managed to integrate the Core's function with the scientific goals of the program project.

结构成像为可视化与认知下降相关的解剖学变化提供了一种手段（例如， 项目3“健康衰老和早期阶段的注意力概况”）以及候选人替代标记 用于检测早期DAT与其他生物标志物的结合（例如，项目2“先例） CSF中的AD的生物标志物”。核心E：成像的目标是收集，存储和传播成像 使用本计划项目调查的数据，也可以促进开发 支持未来成像项目的基础架构。将追求以下具体目标：1。结构性 将与核心密切协调收集有关痴呆和非痴呆参与者的成像数据 B：临床，以两年的纵向间隔。结构成像电池将包括（i）多个 高对比度MP-RAGE图像的采集，（II）3D T2图像用于评估白质。这些 图像将用于测量皮质和皮质下萎缩和白质的评估 完整性，（iii）扩散张量成像以评估白质微结构完整性，（iv）T2-SWI 图像。此外，还将收集有关痴呆和非痴呆参与者的功能成像数据。 功能成像数据将在休息期间是粗体图像，以评估功能连接性。 2。研究 神经放射学评估将由董事会认证的神经放射学家在所有结构图像数据上进行 套。 3。结构数据集将与核心C：生物统计学结合归档，并通过 基于Web的研究人员进行研究项目。 4。定量结构评估将 提供将成像数据与特定于项目的数据相关联，包括（i）整体的自动估计值 脑萎缩，（ii）海马，内嗅，额叶和其他皮质体积的手动估计，（iii） 来自Freesurfer软件（Fischl等，Fischl等）的皮质和皮质下体积的自动估计值 2002; Fischl等，2004； Desikan等，2006）和（iv）白质自动评估 超强度。还将提供定量功能评估，以将成像数据与 特定于项目的数据，并将包括种子区域之间功能连接的估计 海马和前室。 5。与Core C紧密合作：生物统计学和核心A： 管理，数据将设法将核心的功能与程序的科学目标集成在一起 项目。