PATHOLOGY

病理

基本信息

批准号：
7671835
负责人：
WILLIAM L GERALD
金额：
$ 29.26万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-31 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7671835
关键词：
Adherence Age Aliquot Anatomy Antibodies Antigens Archives Area Autopsy Back Basic Science Biocompatible Materials Biological Assay Biostatistics Core Cancer Patient Cell Line Characteristics Classification Clinical Clinical Data Clinical Research Collection Complex Condition Confidentiality of Patient Information Consent Consultations Custom Cytology DNA Daily Data Databases Demography Development Diagnostic Diagnostic Procedure Disease Disease Management Drug or chemical Tissue Distribution Electronics Epidemiology Evaluation Facility Construction Funding Category Formalin Freezing Frozen Sections Funding Health Health Services Research Histologic Histology Hospitals Human Human Resources Image Immunohistochemistry In Situ Hybridization Individual Internet Laboratories Lead Link Maintenance Malignant - descriptor Manuals Memorial Sloan-Kettering Cancer Center Methods Microdissection Microscope Molecular Molecular Analysis Molecular Profiling Nature New York Northern Blotting Nucleic Acids Numbers Online Systems Operating Rooms Paraffin Embedding Pathologic Pathologist Pathology Patients Procedures Process Proteins Protocols documentation PubMed Purpose Quality Control RNA RNA Degradation Range Records Regulation Reporting Research Research Activity Research Ethics Committees Research Personnel Research Project Grants Research Training Residual state Resources Retrieval Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Rights Risk Sampling Secure Services Signal Transduction Site Specimen Staining method Stains Standards of Weights and Measures Supervision Surgical Pathology System Techniques Testing Text Therapeutic Therapeutic procedure Time Tissue Banking Tissue Banks Tissue Embedding Tissue Microarray Tissue Procurements Tissue Sample Tissue Stains Tissues Training Tumor Tissue Universal Precautions Work anticancer research base cDNA Library Construction computing resources data management design digital experience human tissue indexing interest laser capture microdissection macromolecule micromanipulator neoplastic novel patient privacy programs protocol development repository research study response tissue fixing tissue preparation tumor

项目摘要

The Pathology Core serves three basic functions which include tumor procurement and banking, research immunohistochemistry and basic histology services. The Tissue Procurement and Banking Service provides research-driven access to and distribution of fresh or archived tumor tissue to investigators at the Center; priority is accorded to the needs of funded research studies. The frozen tissue repository of MSKCC provides the basis for the expression profiling and other array-based studies that may lead to better classification, prognostication, and therapeutic choices. Its ability to provide disease- and stagespecific tissue in response to protocol-driven studies is essential. Research immunohistochemistry is, performed on fresh frozen and formalin fixed tissue as well as cell lines as requested by investigators. Besides using established antibodies, the facility will optimize staining protocols for novel antibodies as well as determine their staining characteristics on tissues and cell lines. Basic histology services include cutting and staining of fresh frozen and formalin fixed, paraffin embedded tissues and cell lines, tissue microdissection for molecular analysis, and construction of tissue microarrays as well as digital capture of tissue microarray images for signal quantification.

病理核心提供三个基本功能，包括肿瘤采购和银行，研究免疫组织化学和基本组织学服务。组织采购和银行服务提供以研究驱动的访问和分配新鲜或存档的肿瘤组织向研究者的访问和分布中心;优先考虑资助研究的需求。冷冻的组织存储库 MSKCC为表达谱分析和其他基于数组的研究提供了基础，这可能导致更好的分类，预后和治疗选择。它提供疾病和特定于疾病的能力响应于方案驱动的研究的组织至关重要。研究免疫组织化学是按照研究人员要求的固定组织和福尔马林固定组织以及细胞系进行。除了使用既定抗体外，该设施还将优化新型抗体的染色方案如确定其在组织和细胞系上的染色特征。基本的组织学服务包括切割以及新鲜冷冻和福尔马林固定，石蜡嵌入的组织和细胞系的染色微分解用于分子分析，组织微阵列的构建以及数字捕获组织微阵列图像用于信号定量。