Fetal Magnetocardiography Using Non-cryogenic Magnetic Field Sensors

使用非低温磁场传感器进行胎儿心磁图检查

• 批准号: 8313846
• 负责人: Vishal K Shah
• 金额: $ 19.74万
• 依托单位: QUSPIN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8313846
• 关键词: Adopted; Adult; Agreement; Arrhythmia; Capital; Cardiac; Clinical; Congenital Heart Defects; Development; Diagnosis; Diagnostic; Disease; Electrocardiogram; Electronics; Electrophysiology (science); Engineering; Ensure; Environment; Evaluation; Fetal Heart Rate; Fetus; Floor; Frequencies; Goals; Gold; Heart Rate; Human; Institutes; Lasers; Letters; Life; Light; Magnetism; Measurement; Measures; Metals; Methods; Noise; Optics; Patients; Performance; Phase; Physics; Play; Price; Private Sector; Production; Pump; Relaxation; Reliance; Reporting; Research; Resolution; Second Pregnancy Trimester; Signal Transduction; Skin; Speed; Surface; System; Techniques; Technology; Temperature; Testing; Ultrasonography; Universities; Validation; Wisconsin; Work; base; biomagnetism; cost; cost effective; cost effectiveness; cryogenics; design; digital; experience; fetal; fetus at risk; flexibility; heart rhythm; high risk; innovation; magnetic field; non-invasive system; patient safety; sensor; superconducting quantum interference device; tool

DESCRIPTION (provided by applicant): The goal of this project is to develop a low cost, non-invasive system for diagnosis of serious heart rate and rhythm abnormalities in fetus. Postnatally, electrocardiography (ECG) is the gold standard for rhythm assessment. In the fetus, however, the quality of the ECG is too poor for clinical use due to low conductivity of the fetal skin and vernix, which restricts the electrical currents generated by fetal cardiac activity from reaching the maternal surface. In recent years, fetal magnetocardiography (fMCG) has emerged as a promising new tool that overcomes the weaknesses of fetal ECG by detecting magnetic fields instead of electric potentials generated by fetal cardiac activity. Despite its high efficac, fMCG has not been widely adopted due to its reliance on superconductor technology, which is prohibitively expensive and cumbersome. The system that we propose to develop will use latest room-temperate optical magnetometers to drastically reduce the cost of fMCG. Currently, the cost of a fully functional fMCG system is approximately one million dollars. The proposed technology can reduce the price of an fMCG system to $100,000. PUBLIC HEALTH RELEVANCE: The goal of the research is to develop a new magnetic sensor technology for fetal magnetocardiography, a highly promising method of assessing serious fetal heart rate and rhythm disorders. The new sensor technology, which is based on principles of atomic physics, is far more practical and cost-effective than the current technology, which is based on superconductor physics.

描述（由申请人提供）：该项目的目标是开发一种低成本、非侵入性的系统来诊断胎儿严重的心率和节律异常。产后，心电图（ECG）是心律评估的金标准。然而，在胎儿中，由于胎儿皮肤和胎脂的电导率较低，限制了胎儿心脏活动产生的电流到达母体表面，因此心电图的质量太差，不适合临床使用。近年来，胎儿心磁图（fMCG）已成为一种有前途的新工具，它通过检测磁场而不是胎儿心脏活动产生的电位来克服胎儿心电图的弱点。尽管其功效很高，但 fMCG 尚未得到广泛采用，因为它依赖于超导技术，而超导技术成本高昂且繁琐。我们建议开发的系统将使用最新的室温光学磁力计来大幅降低 fMCG 的成本。目前，一个功能齐全的 fMCG 系统的成本约为 100 万美元。所提出的技术可以将 fMCG 系统的价格降低至 100,000 美元。 公共健康相关性：该研究的目标是开发一种用于胎儿心磁图的新型磁传感器技术，这是一种评估严重胎儿心率和节律紊乱的非常有前景的方法。这种基于原子物理学原理的新传感器技术比基于超导体物理学的现有技术更加实用且更具成本效益。